Ulcerative Colitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Allele frequencies and genotype distributions of the C3435T single nucleotide polymorphism were investigated in 149 patients with ulcerative colitis, 126 patients with Crohn's disease, and sex-matched healthy controls.
|
12512026 |
2003 |
Ulcerative Colitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Two polymorphisms (C3435T and G2677T/A) of the multidrug resistance 1 gene have been correlated with the altered P-glycoprotein expression and function in humans, and associated with predisposition to ulcerative colitis and Crohn's disease.
|
16305727 |
2005 |
Ulcerative Colitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
This was a case-control analysis of MDR1 C3435T and G2677T SNPs in a large well-characterized Scottish white cohort (335 with ulcerative colitis [UC], 268 with Crohn's disease [CD], and 370 healthy controls).
|
15685540 |
2005 |
Ulcerative Colitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study was conducted to find a possible reason for the discrepancies, and it was suggested that the age of onset was important for the association, namely, C3435T was predictive of susceptibility to later onset UC, but not for early onset UC.
|
16462040 |
2006 |
Ulcerative Colitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The polymorphism Ala893Ser/Thr (G2677T/A) previously showed significant association with Crohn's disease (CD) and the Ile1145Ile (C3435T) with ulcerative colitis (UC).
|
16374256 |
2006 |
Ulcerative Colitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
A meta-analysis of 9 association studies of C34</span>35T showed a significant association of the 3435T allele with UC (OR 1.12; 95% CI 1.02-1.23; P = 0.013) but not with CD.
|
16633048 |
2006 |
Ulcerative Colitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The distribution of the different genotypes of single nucleotide polymorphisms (SNP) G2677T/A and C3435T of MDR1 exons 21 and 26, respectively, was studied in 154 patients (mean age, 44 yr) who had received CsA to treat severe attacks of steroid resistant UC in 11 centers in France and Belgium.
|
17206635 |
2007 |
Ulcerative Colitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
No significant difference was observed for genotype frequencies for both MDR1 G2677T/A and C3435T polymorphisms on overall disease susceptibility for either CD or UC patients compared with control subjects.
|
17260353 |
2007 |
Ulcerative Colitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study suggests that C3435T polymorphism of the MDR1 gene has an association with ulcerative colitis in Iranian population as previously reported in western countries.
|
17242936 |
2007 |
Ulcerative Colitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated DNA methylation of the MDR1 gene in ulcerative colitis (UC) and its relation to MDR1 C3435T genotypes.Eighty-three UC patients were enrolled.
|
19288029 |
2009 |
Ulcerative Colitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Three-marker (C1236T, G2677T/A, C3435T) and two-marker (C1236T, G2677T/A) haplotype analysis revealed significant associations with UC (TTT, P=0.04; TGT, P=0.01; TT, P=0.01; CT, P=0.03).
|
19005421 |
2009 |
Ulcerative Colitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Because Tac response in patients who have undergone solid-organ transplantation has been associated with the presence of variants in CYP3A and ABCB1, we elucidated the contributions of CYP3A4*1B and CYP3A5*3 and of ABCB1 1236C>T, 2677G>T,A, and 3435C>T polymorphisms to Tac response in 89 patients with UC.
|
21289623 |
2011 |
Ulcerative Colitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The analysis showed marginal significant association for the C3435T variant in UC: the risk estimate for the allele contrast was OR = 1.11 (1.00-1.22) and OR(G) = 1.12 (1.01-1.27), indicating that a subject with high mutational load has a 12% higher probability of being diseased.
|
21887726 |
2012 |
Ulcerative Colitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The C3435T polymorphism of the ABCB1/MDR1 gene is not a risk factor for IBD, including UC and CD, in the population coming from central Poland.
|
22661185 |
2012 |
Ulcerative Colitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Finally, active UC in patients carrying the TLR2-R753Q and MDR1-C3435T polymorphisms was associated with increased nuclear expression of caspase-1 protein and cell death in areas of acute inflammation, compared with active UC patients without these variants.
|
23636052 |
2013 |
Ulcerative Colitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Besides, stratified analysis by clinical type also indicated that no significant association between MDR1 C3435T and the risk of Crohn's disease and ulcerative colitis was observed.
|
24449364 |
2014 |
Ulcerative Colitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
While, no remarkable relationship is observed between ABCB1 C3435T polymorphisms and UC.
|
25755800 |
2015 |
Ulcerative Colitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
CTLA-4 gene rs3087243 G > A and rs231775 G > A, and MDR1 gene rs1045642 C > T might confer an increase for UC risk.
|
26379408 |
2015 |
Ulcerative Colitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The current study suggests that CYP2D6*4 and MDR1 3435 C/T gene polymorphisms may be risk factors for UC susceptibility.
|
30551694 |
2018 |
Ulcerative Colitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
On the other hand, C allele and CC genotype of C1236T and C3435T, as well as G allele and GG genotype of G2677T/A were more frequent in healthy subjects, implying protective role of these variants in UC.
|
29543864 |
2018 |