|
Acute Chest Syndrome
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our meta-analysis results indicated that ABCB1 C3435T</span> polymorphism may be associated with an increased risk of MI and ACS, especially among Asian populations (T allele vs. C allele: OR=1.40, 95% CI=1.31-1.49, ph=0.058).
|
25118983 |
2014 |
|
Acute Chest Syndrome
|
|
0.020 |
GeneticVariation
|
BEFREE |
The current meta-analysis suggests that ABCB1 C3435T polymorphism may contribute to the risk of CHD, especially for MI and ACS, among Caucasian populations.
|
24328528 |
2014 |
|
Acute Coronary Syndrome
|
|
0.020 |
GeneticVariation
|
BEFREE |
Genetic polymorphisms of CYP2C19 2 and ABCB1 C3435T affect the pharmacokinetic and pharmacodynamic responses to clopidogrel in 401 patients with acute coronary syndrome.
|
25542807 |
2015 |
|
Acute Coronary Syndrome
|
|
0.020 |
GeneticVariation
|
BEFREE |
The C3435T polymorphism of the MDR-1 gene influences ADP dependent platelet reactivity in patients with acute coronary syndrome but does not affect mid-term prognosis in this population.
|
19784880 |
2009 |
|
Acute idiopathic thrombocytopenic purpura
|
|
0.010 |
GeneticVariation
|
BEFREE |
Relation between 3435C>T multidrug resistance 1 gene polymorphism with high dose methylprednisolone treatment of childhood acute idiopathic thrombocytopenic purpura.
|
21718764 |
2011 |
|
Acute leukemia
|
|
0.030 |
GeneticVariation
|
BEFREE |
Association of an MDR1 gene (C3435T) polymorphism with acute leukemia in India.
|
21133625 |
2010 |
|
Acute leukemia
|
|
0.030 |
GeneticVariation
|
BEFREE |
Our results suggest that the ABCB1 G2677T and C3435T sequence variations may affect susceptibility to acute leukemia.
|
27706688 |
2016 |
|
Acute leukemia
|
|
0.030 |
GeneticVariation
|
BEFREE |
ABCB1 3435C > T polymorphisms may be associated with susceptibility to acute leukemia, and ABCB1 polymorphisms might be a sensitive indicator for predicting efficacy of MTX therapy in the treatment of acute leukemia.
|
25921280 |
2015 |
|
Acute lymphocytic leukemia
|
|
0.060 |
GeneticVariation
|
BEFREE |
This meta-analysis suggests there was no association between MDR1 C3435T polymorphism and children ALL risk in overall populations, but significant association with an increased risk in Asians.
|
25661341 |
2015 |
|
Acute lymphocytic leukemia
|
|
0.060 |
GeneticVariation
|
BEFREE |
MDR1 C3435T polymorphism in Mexican children with acute lymphoblastic leukemia and in healthy individuals.
|
19317599 |
2008 |
|
Acute lymphocytic leukemia
|
|
0.060 |
GeneticVariation
|
BEFREE |
In terms of infection incidence, polymorphism C3435T may contribute to potential life-threatening infections during paediatric ALL therapy, through glucocorticoid usage.
|
30508724 |
2019 |
|
Acute lymphocytic leukemia
|
|
0.060 |
GeneticVariation
|
BEFREE |
There were no association in distribution of genotypes of MDR-1 C3435T polymorphism and the risk of ALL.
|
23244145 |
2012 |
|
Acute lymphocytic leukemia
|
|
0.060 |
GeneticVariation
|
BEFREE |
To investigate their possible roles in disease susceptibility and some disease characteristics we genotyped C3435T and G2677T/A polymorphisms in multidrug resistance-1 (MDR1) gene with a single base extension method and the G34A and C421A polymorphisms of the breast cancer resistance protein gene with an allelic discrimination system in 396 children with acute lymphoblastic leukaemia (ALL) and 192 control patients.
|
18243305 |
2008 |
|
Acute lymphocytic leukemia
|
|
0.060 |
GeneticVariation
|
BEFREE |
In conclusion, we do not have reason to assume that the C3435T SNP contributes to drug resistance of ALL and prognosis of ALL patients.
|
12851703 |
2003 |
|
Acute monocytic leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of this study was to investigate the potential involvement of the ABCB1 gene exon 26 3435C>T single nucleotide polymorphism (SNP) in the genetic susceptibility to AML and regulation of P-gp expression and activity in AML cells.
|
17038891 |
2006 |
|
Adenocarcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
MDR1 T-129C, but not G2677A,T and C3435T, was associated with the lower expression of MDR1 mRNA both in colorectal adenocarcinomas (p=0.040) and adjacent noncancerous colorectal tissues (p=0.023), possibly being an useful invasive marker predicting poorly-differentiated colorectal adenocarcinomas and thereby the poor prognosis of the patients, especially when no extra biopsy samples will be obtained.
|
16819187 |
2006 |
|
Adult Acute Lymphocytic Leukemia
|
|
0.040 |
GeneticVariation
|
BEFREE |
Our results suggest that C3435T polymorphism in MDR1 gene is not a major prognosticator in adult ALL.
|
16382213 |
2006 |
|
Adult Acute Lymphocytic Leukemia
|
|
0.040 |
GeneticVariation
|
BEFREE |
In conclusion, we do not have reason to assume that the C3435T SNP contributes to drug resistance of ALL and prognosis of ALL patients.
|
12851703 |
2003 |
|
Adult Acute Lymphocytic Leukemia
|
|
0.040 |
GeneticVariation
|
BEFREE |
This meta-analysis suggests there was no association between MDR1 C3435T polymorphism and children ALL risk in overall populations, but significant association with an increased risk in Asians.
|
25661341 |
2015 |
|
Adult Acute Lymphocytic Leukemia
|
|
0.040 |
GeneticVariation
|
BEFREE |
There were no association in distribution of genotypes of MDR-1 C3435T polymorphism and the risk of ALL.
|
23244145 |
2012 |
|
Adult Acute Myeloblastic Leukemia
|
|
0.020 |
GeneticVariation
|
BEFREE |
MDR1 C3435T polymorphism influences the development of colon cancer and adult acute myeloid leukemia by the association with transporting carcinogen.
|
18644389 |
2008 |
|
Adult Acute Myeloblastic Leukemia
|
|
0.020 |
GeneticVariation
|
BEFREE |
The authors conclude that isolated 3435C>T ABCB1 SNP is not a major factor of the genetic susceptibility to adult AML, and that genotyping of this polymorphism does not allow predicting P-gp expression or activity in AML cells.
|
17038891 |
2006 |
|
Adult Glioblastoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Although the C3435T polymorphism does not appear to be associated with other types of glioma, we cannot rule out that this MDR1 polymorphism may be associated with glioblastoma among men.
|
15947495 |
2005 |
|
Adult Hodgkin Lymphoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
these results suggest that MDR1 C3435T polymorphism might play a role in HL occurrence; however this polymorphism is not correlated with the clinical response to ABVD.
|
21762523 |
2011 |
|
Advanced breast cancer
|
|
0.010 |
GeneticVariation
|
BEFREE |
The available evidence indicates that MDR1 C3435T polymorphism cannot be considered as a reliable predictor of response to chemotherapy in patients with advanced breast cancer.
|
22160574 |
2012 |