|
Major Depressive Disorder
|
|
0.070 |
GeneticVariation
|
BEFREE |
MDD is associated with the rs2032582 (<i>G2677T</i>) and rs1128503 (<i>C1236T</i>) single-nucleotide polymorphisms (SNPs) of <i>ABCB1</i> but not with rs1045642, rs2032583, rs2235040, and rs2235015.
|
31333472 |
2019 |
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
We observed difference in SNPs in MDR1 gene C3435T p</span>olymorphism between breast cancer patients and healthy controls (chi(2) = 8.66, df = 2, p = 0.013).
|
17560460 |
2007 |
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We observed difference in SNPs in MDR1 gene C3435T p</span>olymorphism between breast cancer patients and healthy controls (chi(2) = 8.66, df = 2, p = 0.013).
|
17560460 |
2007 |
|
Leukemia, Myelocytic, Acute
|
|
0.040 |
GeneticVariation
|
BEFREE |
C3435T polymorphism of the MDR1 gene is not associated with P-glycoprotein function of leukemic blasts and clinical outcome in patients with acute myeloid leukemia.
|
18272218 |
2008 |
|
Cholangiocarcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
C3435T genotype was an independent predictive factor of good response in breast (response >50 %, i.e., Sataloff T-A and T-B): OR: 4.6 (95 % CI: 1.3-16.1), p = 0.015, for TT patients versus CT and CC patients.
|
23666532 |
2013 |
|
Leukopenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
C3435T polymorphisms of ABCB1 might be able to predict severe amrubicin-induced neutropenia.
|
24982363 |
2014 |
|
Neutropenia
|
|
0.080 |
GeneticVariation
|
BEFREE |
C3435T polymorphisms of ABCB1 might be able to predict severe amrubicin-induced neutropenia.
|
24982363 |
2014 |
|
Childhood Acute Lymphoblastic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
C3435T and C1236T MDR1 polymorphism are significantly associated with the high-risk group (OR=2.6, 95%CI=1.164-5.808; P=0.028 and OR=2.231, 95%CI=1.068-4.659; p=0.047, respectively), indicating that both may be candidates for molecular markers in the high-risk group of ALL.
|
25854371 |
2015 |
|
Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
C3435T polymorphism of MDR1 gene was analysed by the high resolution melting technique in a group of patients with drug-resistant (n = 106) and drug-responsive epilepsy (n = 67), as well as in non-epileptic children (n = 98) hospitalised at the Department of Neurology, Polish Mother's Memorial Hospital in Lodz.
|
27391700 |
2016 |
|
Ulcerative Colitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
A meta-analysis of 9 association studies of C34</span>35T showed a significant association of the 3435T allele with UC (OR 1.12; 95% CI 1.02-1.23; P = 0.013) but not with CD.
|
16633048 |
2006 |
|
Inflammatory Bowel Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
A meta-analysis was carried out of our results and those from 8 previously published association studies of the C3435T variant in inflammatory bowel disease.
|
16633048 |
2006 |
|
Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
A meta-analysis was conducted to assess the role of the C3435T polymorphism in drug-resistance in epilepsy.
|
24794827 |
2014 |
|
Sporadic Breast Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
A polymorphism C3435T of the MDR-1 gene associated with smoking or high body mass index increases the risk of sporadic breast cancer in women.
|
17549370 |
2007 |
|
Parkinsonian Disorders
|
|
0.020 |
GeneticVariation
|
BEFREE |
A significant association between patients with parkinsonism exposed to pesticides and C3435T polymorphism of the MDR1 gene was found.
|
12724617 |
2003 |
|
Crohn Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
A significant association of MDR1 C3435T with CD was observed (CC vs (CT + TT): P = 0.007; OR [95% CI] = 1.58 [1.12-2.23]).
|
16374256 |
2006 |
|
Major Depressive Disorder
|
|
0.070 |
GeneticVariation
|
BEFREE |
A significant protection for MDD males carrying the T allele was observed (C1236T: odds ratio (OR)=0.360, 95% confidence interval [CI]: [0.140-0.950], p=0.022; C3435T: OR=0.306, 95% CI: [0.096-0.980], p=0.042; and G2677TA: OR=0.300, 95% CI: [0.100-0.870], p=0.013).
|
24200053 |
2014 |
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
A statistical association was observed between p53 codon 72 polymorphism and family history of breast cancer in both groups, as well as between MDR1 C3435T and smoking habits in cases (P<0.05).Gene polymorphisms vary by regions.
|
19885596 |
2009 |
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
A statistical association was observed between p53 codon 72 polymorphism and family history of breast cancer in both groups, as well as between MDR1 C3435T and smoking habits in cases (P<0.05).Gene polymorphisms vary by regions.
|
19885596 |
2009 |
|
Mixed cryoglobulinemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
ABCB1 (gene encoding P-glycoprotein) 3435C>T SNP was associated with MC presence (p = 0.034): related to T allele carriers (CC vs CT/TT), we reached a p-value of 0.013.
|
28453396 |
2017 |
|
Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
ABCB1 3435C>T was genotyped in 746 Han Chinese patients with epilepsy and 179 controls.
|
17521963 |
2007 |
|
Coronary Artery Disease
|
|
0.040 |
GeneticVariation
|
BEFREE |
ABCB1 C3435T polymorphism and response to clopidogrel treatment in coronary artery disease (CAD) patients: a meta-analysis.
|
23056288 |
2012 |
|
Coronary Artery Disease
|
|
0.040 |
GeneticVariation
|
BEFREE |
ABCB1 C3435T polymorphism and the risk of coronary heart disease: a meta-analysis.
|
24328528 |
2014 |
|
Coronary Arteriosclerosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
ABCB1 C3435T polymorphism and the risk of coronary heart disease: a meta-analysis.
|
24328528 |
2014 |
|
Myocardial Ischemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
ABCB1 C3435T polymorphism and the risk of ischemic heart disease: a meta-analysis.
|
25118983 |
2014 |
|
Acute leukemia
|
|
0.030 |
GeneticVariation
|
BEFREE |
ABCB1 3435C > T polymorphisms may be associated with susceptibility to acute leukemia, and ABCB1 polymorphisms might be a sensitive indicator for predicting efficacy of MTX therapy in the treatment of acute leukemia.
|
25921280 |
2015 |