rs1045642, ABCB1

N. diseases: 214
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Crohn Disease
CUI: C0010346
Disease: Crohn Disease
0.100 GeneticVariation BEFREE No significant difference was observed for genotype frequencies for both MDR1 G2677T/A and C3435T polymorphisms on overall disease susceptibility for either CD or UC patients compared with control subjects. 17260353 2007
Crohn Disease
CUI: C0010346
Disease: Crohn Disease
0.100 GeneticVariation BEFREE We have detected no significant association of C3435T SNP and pediatric CD. 27603561 2016
Crohn Disease
CUI: C0010346
Disease: Crohn Disease
0.100 GeneticVariation BEFREE The CC genotypes of rs1128503 and rs1045642 in MDR1 gene were more frequent in Crohn's disease (CD) patients who were GC-dependent than in those responsive to GC (odds ratio [OR] 6.583, 95% confidence interval [CI] 1.760-24.628, P = 0.019 and OR 3.873, 95% CI 1.578-9.506, P = 0.009, respectively). 25346426 2015
Crohn Disease
CUI: C0010346
Disease: Crohn Disease
0.100 GeneticVariation BEFREE To investigate the contribution of multidrug resistance 1 (MDR1) gene pharmacogenetics (G2677T/A and C3435T) to the efficacy of azathioprine in inducing remission in patients with Crohn's disease (CD). 17262810 2007
Crohn Disease
CUI: C0010346
Disease: Crohn Disease
0.100 GeneticVariation BEFREE Allele frequencies of the cyclooxygenase 2 (COX-2/PTGS2/PGHS2) G-765C and breast cancer resistance protein (BCRP/ABCG2) C421A as well as allele and haplotype frequencies of multidrug resistance 1 (MDR1, ABCB1) SNPs G2677T/A, C3435T and G-rs3789243-A (intron 3) were assessed in a Danish case-control study comprising 373 CD and 541 UC patients and 796 healthy controls. 18819034 2009
Crohn Disease
CUI: C0010346
Disease: Crohn Disease
0.100 GeneticVariation BEFREE ABCB1 3435C>T and 2677G>T/A polymorphisms in Polish and Bosnian patients with Crohn's disease - A preliminary report. 28759738 2017
Crohn Disease
CUI: C0010346
Disease: Crohn Disease
0.100 GeneticVariation BEFREE A significant association of MDR1 C3435T with CD was observed (CC vs (CT + TT): P = 0.007; OR [95% CI] = 1.58 [1.12-2.23]). 16374256 2006
Crohn Disease
CUI: C0010346
Disease: Crohn Disease
0.100 GeneticVariation BEFREE Two common single nucleotide polymorphisms (SNPs), C3435T and G2677T/A, thought to alter the function of the corresponding P-glycoprotein, have shown inconsistent associations with CD. 19107781 2009
Crohn Disease
CUI: C0010346
Disease: Crohn Disease
0.100 GeneticVariation BEFREE The C3435T polymorphism of the ABCB1/MDR1 gene is not a risk factor for IBD, including UC and CD, in the population coming from central Poland. 22661185 2012
Crohn Disease
CUI: C0010346
Disease: Crohn Disease
0.100 GeneticVariation BEFREE Besides, stratified analysis by clinical type also indicated that no significant association between MDR1 C3435T and the risk of Crohn's disease and ulcerative colitis was observed. 24449364 2014
Crohn Disease
CUI: C0010346
Disease: Crohn Disease
0.100 GeneticVariation BEFREE Heterozygous carriers for C3435T were significantly less likely to have CD (p=0.02; OR 0.58, 95% CI (0.36-0.91)). 23537364 2013
Crohn Disease
CUI: C0010346
Disease: Crohn Disease
0.100 GeneticVariation BEFREE Three hundred eighty-eight German IBD patients [244 with Crohn's disease (CD), 144 with ulcerative colitis (UC)] and 1,005 German healthy controls were genotyped for the two MDR1 SNPs on positions 2677G>T/A and 3435C>T. 17665184 2007
Crohn Disease
CUI: C0010346
Disease: Crohn Disease
0.100 GeneticVariation BEFREE Two polymorphisms (C3435T and G2677T/A) of the multidrug resistance 1 gene have been correlated with the altered P-glycoprotein expression and function in humans, and associated with predisposition to ulcerative colitis and Crohn's disease. 16305727 2005
Crohn Disease
CUI: C0010346
Disease: Crohn Disease
0.100 GeneticVariation BEFREE This was a case-control analysis of MDR1 C3435T and G2677T SNPs in a large well-characterized Scottish white cohort (335 with ulcerative colitis [UC], 268 with Crohn's disease [CD], and 370 healthy controls). 15685540 2005