rs1045642, ABCB1

N. diseases: 214
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Major Depressive Disorder
CUI: C1269683
Disease: Major Depressive Disorder
0.070 GeneticVariation BEFREE We examined this SNP in patients with major depression enrolled in a randomized antidepressant treatment trial of nortriptyline and fluoxetine, and observed a significant association between nortriptyline-induced postural hypotension and 3435C>T (chi(2) = 6.78, df = 2, P = 0.034). 12082591 2002
Unipolar Depression
CUI: C0041696
Disease: Unipolar Depression
0.050 GeneticVariation BEFREE We examined this SNP in patients with major depression enrolled in a randomized antidepressant treatment trial of nortriptyline and fluoxetine, and observed a significant association between nortriptyline-induced postural hypotension and 3435C>T (chi(2) = 6.78, df = 2, P = 0.034). 12082591 2002
Neoplasms
CUI: C0027651
Disease: Neoplasms
0.040 GeneticVariation BEFREE The estimated allele frequencies of functional polymorphisms in(of) exon 21 (2677 G>T, Ala893Ser) and exon 26(3435 C>T, Ilel 142I1e) of the MDR] gene were 0.42 and 0.46 in the controls and 0.54 (p=0.035) and 0.60 (p=0.017) in the MSI-H tumors. 11980438 2002
Epithelioma
CUI: C1368683
Disease: Epithelioma
0.010 GeneticVariation BEFREE The data provide evidence for PGP to influence the susceptibility to develop renal epithelial tumors by virtue of its MDR1(C3435T) polymorphism and changes in expression. 12089380 2002
Hypotension, Orthostatic
CUI: C0020651
Disease: Hypotension, Orthostatic
0.010 GeneticVariation BEFREE We examined this SNP in patients with major depression enrolled in a randomized antidepressant treatment trial of nortriptyline and fluoxetine, and observed a significant association between nortriptyline-induced postural hypotension and 3435C>T (chi(2) = 6.78, df = 2, P = 0.034). 12082591 2002
Colorectal Neoplasms
CUI: C0009404
Disease: Colorectal Neoplasms
0.010 GeneticVariation BEFREE Functional MDR1 polymorphisms (G2677T and C3435T) and TCF4 mutations in colorectal tumors with high microsatellite instability. 11980438 2002
Ulcerative Colitis
CUI: C0009324
Disease: Ulcerative Colitis
0.100 GeneticVariation BEFREE Allele frequencies and genotype distributions of the C3435T single nucleotide polymorphism were investigated in 149 patients with ulcerative colitis, 126 patients with Crohn's disease, and sex-matched healthy controls. 12512026 2003
Inflammatory Bowel Diseases
CUI: C0021390
Disease: Inflammatory Bowel Diseases
0.100 GeneticVariation BEFREE Significant association of Ala893 with IBD was observed by both case-control analysis (P=.002) and the pedigree disequilibrium test (PDT [P=.00020-.00030]) but not for the Asn21Asp or C3435T polymorphisms. 14610718 2003
Childhood Acute Lymphoblastic Leukemia
0.100 GeneticVariation BEFREE In conclusion, we do not have reason to assume that the C3435T SNP contributes to drug resistance of ALL and prognosis of ALL patients. 12851703 2003
Colorectal Carcinoma
CUI: C0009402
Disease: Colorectal Carcinoma
0.100 GeneticVariation BEFREE MDR1 single nucleotide polymorphism C3435T in normal colorectal tissue and colorectal carcinomas detected by MALDI-TOF mass spectrometry. 12894567 2003
Acute lymphocytic leukemia
CUI: C0023449
Disease: Acute lymphocytic leukemia
0.060 GeneticVariation BEFREE In conclusion, we do not have reason to assume that the C3435T SNP contributes to drug resistance of ALL and prognosis of ALL patients. 12851703 2003
Adult Acute Lymphocytic Leukemia
CUI: C0751606
Disease: Adult Acute Lymphocytic Leukemia
0.040 GeneticVariation BEFREE In conclusion, we do not have reason to assume that the C3435T SNP contributes to drug resistance of ALL and prognosis of ALL patients. 12851703 2003
Neoplasms
CUI: C0027651
Disease: Neoplasms
0.040 GeneticVariation BEFREE We analyzed the C3435T SNP in the MDR1 gene which is associated with altered cellular drug uptake in matched tumor and normal tissues of 45 patients suffering from colorectal carcinoma. 12894567 2003
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.030 GeneticVariation BEFREE Analysis of single nucleotide polymorphism C3435T of the multidrug resistance gene MDR1 in acute lymphoblastic leukemia. 12851703 2003
Parkinsonian Disorders
CUI: C0242422
Disease: Parkinsonian Disorders
0.020 GeneticVariation BEFREE A significant association between patients with parkinsonism exposed to pesticides and C3435T polymorphism of the MDR1 gene was found. 12724617 2003
Locally advanced breast cancer
CUI: C3495949
Disease: Locally advanced breast cancer
0.020 GeneticVariation BEFREE Polymorphism C3435T of the MDR-1 gene predicts response to preoperative chemotherapy in locally advanced breast cancer. 12684679 2003
Childhood Acute Lymphoblastic Leukemia
0.100 GeneticVariation BEFREE In conclusion, the results of the present study provide evidence that C3435T MDR1 polymorphism may involve both the susceptibility to and the clinical outcome of childhood ALL. 15059065 2004
Parkinson Disease
CUI: C0030567
Disease: Parkinson Disease
0.060 GeneticVariation BEFREE The frequency of each individual SNPs; -41 A > G (intron -1), -145 C > G (exon 1), -129 T > C (exon 1), 1236 T > C (exon 12), 2677 G > T/A (exon 21), 3435 C > T (exon 26), and 4036 A > G (exon 28) did not differ between PD and controls. 15542248 2004
Non-Small Cell Lung Carcinoma
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
0.060 GeneticVariation BEFREE Using the TaqMan 5' nuclease assay, we examined ERCC1 118, XPD 751 and 312, RRM1 -37C/A, and MDR1 C3435T SNPs in peripheral blood lymphocytes (PBLs) obtained from 62 docetaxel-cisplatin-treated advanced NSCLC patients. 15277258 2004
Balkan Nephropathy
CUI: C0004698
Disease: Balkan Nephropathy
0.010 GeneticVariation BEFREE The constitutional genotype frequencies of two SNPs (C3435T and G2677T) in the MDR1 gene in 112 healthy control subjects were investigated and compared with those of 96 patients with BEN. 14752243 2004
Malignant Neoplasms
CUI: C0006826
Disease: Malignant Neoplasms
0.100 GeneticVariation BEFREE These results suggest that ABCB1 3435C>T polymorphism is associated with antiemetic treatment efficacy in patients with cancer treated with 5-HT(3) antagonists, particularly in granisetron-treated patients, during the short-term phase of chemotherapy. 16338277 2005
Epilepsy
CUI: C0014544
Disease: Epilepsy
0.100 GeneticVariation BEFREE Whether the C3435T polymorphism can act as a marker for the natural history of treated epilepsy remains to be determined. 15857428 2005
Ulcerative Colitis
CUI: C0009324
Disease: Ulcerative Colitis
0.100 GeneticVariation BEFREE Two polymorphisms (C3435T and G2677T/A) of the multidrug resistance 1 gene have been correlated with the altered P-glycoprotein expression and function in humans, and associated with predisposition to ulcerative colitis and Crohn's disease. 16305727 2005
Ulcerative Colitis
CUI: C0009324
Disease: Ulcerative Colitis
0.100 GeneticVariation BEFREE This was a case-control analysis of MDR1 C3435T and G2677T SNPs in a large well-characterized Scottish white cohort (335 with ulcerative colitis [UC], 268 with Crohn's disease [CD], and 370 healthy controls). 15685540 2005
Childhood Acute Lymphoblastic Leukemia
0.100 GeneticVariation BEFREE In a matched case-control study, we investigated the associations between CNS relapse in childhood ALL and the presence of phenotypically relevant single nucleotide polymorphisms within the GSTP1 (codon 105 and 114) and MDR1 genes (ABCB1; coding for Pgp; exon 26, C3435T). 15717687 2005