Major Depressive Disorder
|
|
0.070 |
GeneticVariation
|
BEFREE |
We examined this SNP in patients with major depression enrolled in a randomized antidepressant treatment trial of nortriptyline and fluoxetine, and observed a significant association between nortriptyline-induced postural hypotension and 3435C>T (chi(2) = 6.78, df = 2, P = 0.034).
|
12082591 |
2002 |
Unipolar Depression
|
|
0.050 |
GeneticVariation
|
BEFREE |
We examined this SNP in patients with major depression enrolled in a randomized antidepressant treatment trial of nortriptyline and fluoxetine, and observed a significant association between nortriptyline-induced postural hypotension and 3435C>T (chi(2) = 6.78, df = 2, P = 0.034).
|
12082591 |
2002 |
Neoplasms
|
|
0.040 |
GeneticVariation
|
BEFREE |
The estimated allele frequencies of functional polymorphisms in(of) exon 21 (2677 G>T, Ala893Ser) and exon 26(3435 C>T, Ilel 142I1e) of the MDR] gene were 0.42 and 0.46 in the controls and 0.54 (p=0.035) and 0.60 (p=0.017) in the MSI-H tumors.
|
11980438 |
2002 |
Epithelioma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The data provide evidence for PGP to influence the susceptibility to develop renal epithelial tumors by virtue of its MDR1(C3435T) polymorphism and changes in expression.
|
12089380 |
2002 |
Hypotension, Orthostatic
|
|
0.010 |
GeneticVariation
|
BEFREE |
We examined this SNP in patients with major depression enrolled in a randomized antidepressant treatment trial of nortriptyline and fluoxetine, and observed a significant association between nortriptyline-induced postural hypotension and 3435C>T (chi(2) = 6.78, df = 2, P = 0.034).
|
12082591 |
2002 |
Colorectal Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
Functional MDR1 polymorphisms (G2677T and C3435T) and TCF4 mutations in colorectal tumors with high microsatellite instability.
|
11980438 |
2002 |
Ulcerative Colitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Allele frequencies and genotype distributions of the C3435T single nucleotide polymorphism were investigated in 149 patients with ulcerative colitis, 126 patients with Crohn's disease, and sex-matched healthy controls.
|
12512026 |
2003 |
Inflammatory Bowel Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
Significant association of Ala893 with IBD was observed by both case-control analysis (P=.002) and the pedigree disequilibrium test (PDT [P=.00020-.00030]) but not for the Asn21Asp or C3435T polymorphisms.
|
14610718 |
2003 |
Childhood Acute Lymphoblastic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, we do not have reason to assume that the C3435T SNP contributes to drug resistance of ALL and prognosis of ALL patients.
|
12851703 |
2003 |
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
MDR1 single nucleotide polymorphism C3435T in normal colorectal tissue and colorectal carcinomas detected by MALDI-TOF mass spectrometry.
|
12894567 |
2003 |
Acute lymphocytic leukemia
|
|
0.060 |
GeneticVariation
|
BEFREE |
In conclusion, we do not have reason to assume that the C3435T SNP contributes to drug resistance of ALL and prognosis of ALL patients.
|
12851703 |
2003 |
Adult Acute Lymphocytic Leukemia
|
|
0.040 |
GeneticVariation
|
BEFREE |
In conclusion, we do not have reason to assume that the C3435T SNP contributes to drug resistance of ALL and prognosis of ALL patients.
|
12851703 |
2003 |
Neoplasms
|
|
0.040 |
GeneticVariation
|
BEFREE |
We analyzed the C3435T SNP in the MDR1 gene which is associated with altered cellular drug uptake in matched tumor and normal tissues of 45 patients suffering from colorectal carcinoma.
|
12894567 |
2003 |
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
Analysis of single nucleotide polymorphism C3435T of the multidrug resistance gene MDR1 in acute lymphoblastic leukemia.
|
12851703 |
2003 |
Parkinsonian Disorders
|
|
0.020 |
GeneticVariation
|
BEFREE |
A significant association between patients with parkinsonism exposed to pesticides and C3435T polymorphism of the MDR1 gene was found.
|
12724617 |
2003 |
Locally advanced breast cancer
|
|
0.020 |
GeneticVariation
|
BEFREE |
Polymorphism C3435T of the MDR-1 gene predicts response to preoperative chemotherapy in locally advanced breast cancer.
|
12684679 |
2003 |
Childhood Acute Lymphoblastic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, the results of the present study provide evidence that C3435T MDR1 polymorphism may involve both the susceptibility to and the clinical outcome of childhood ALL.
|
15059065 |
2004 |
Parkinson Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
The frequency of each individual SNPs; -41 A > G (intron -1), -145 C > G (exon 1), -129 T > C (exon 1), 1236 T > C (exon 12), 2677 G > T/A (exon 21), 3435 C > T (exon 26), and 4036 A > G (exon 28) did not differ between PD and controls.
|
15542248 |
2004 |
Non-Small Cell Lung Carcinoma
|
|
0.060 |
GeneticVariation
|
BEFREE |
Using the TaqMan 5' nuclease assay, we examined ERCC1 118, XPD 751 and 312, RRM1 -37C/A, and MDR1 C3435T SNPs in peripheral blood lymphocytes (PBLs) obtained from 62 docetaxel-cisplatin-treated advanced NSCLC patients.
|
15277258 |
2004 |
Balkan Nephropathy
|
|
0.010 |
GeneticVariation
|
BEFREE |
The constitutional genotype frequencies of two SNPs (C3435T and G2677T) in the MDR1 gene in 112 healthy control subjects were investigated and compared with those of 96 patients with BEN.
|
14752243 |
2004 |
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results suggest that ABCB1 3435C>T polymorphism is associated with antiemetic treatment efficacy in patients with cancer treated with 5-HT(3) antagonists, particularly in granisetron-treated patients, during the short-term phase of chemotherapy.
|
16338277 |
2005 |
Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
Whether the C3435T polymorphism can act as a marker for the natural history of treated epilepsy remains to be determined.
|
15857428 |
2005 |
Ulcerative Colitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Two polymorphisms (C3435T and G2677T/A) of the multidrug resistance 1 gene have been correlated with the altered P-glycoprotein expression and function in humans, and associated with predisposition to ulcerative colitis and Crohn's disease.
|
16305727 |
2005 |
Ulcerative Colitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
This was a case-control analysis of MDR1 C3435T and G2677T SNPs in a large well-characterized Scottish white cohort (335 with ulcerative colitis [UC], 268 with Crohn's disease [CD], and 370 healthy controls).
|
15685540 |
2005 |
Childhood Acute Lymphoblastic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
In a matched case-control study, we investigated the associations between CNS relapse in childhood ALL and the presence of phenotypically relevant single nucleotide polymorphisms within the GSTP1 (codon 105 and 114) and MDR1 genes (ABCB1; coding for Pgp; exon 26, C3435T).
|
15717687 |
2005 |