rs1045642, ABCB1

N. diseases: 108
Source: ALL
Disease Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Ulcerative Colitis
CUI: C0009324
Disease: Ulcerative Colitis
0.100 GeneticVariation BEFREE CTLA-4 gene rs3087243 G > A and rs231775 G > A, and MDR1 gene rs1045642 C > T might confer an increase for UC risk. 26379408 2016
Ulcerative Colitis
CUI: C0009324
Disease: Ulcerative Colitis
0.100 GeneticVariation BEFREE Finally, active UC in patients carrying the TLR2-R753Q and MDR1-C3435T polymorphisms was associated with increased nuclear expression of caspase-1 protein and cell death in areas of acute inflammation, compared with active UC patients without these variants. 23636052 2013
Ulcerative Colitis
CUI: C0009324
Disease: Ulcerative Colitis
0.100 GeneticVariation BEFREE The analysis showed marginal significant association for the C3435T variant in UC: the risk estimate for the allele contrast was OR = 1.11 (1.00-1.22) and OR(G) = 1.12 (1.01-1.27), indicating that a subject with high mutational load has a 12% higher probability of being diseased. 21887726 2012
Ulcerative Colitis
CUI: C0009324
Disease: Ulcerative Colitis
0.100 GeneticVariation BEFREE Because Tac response in patients who have undergone solid-organ transplantation has been associated with the presence of variants in CYP3A and ABCB1, we elucidated the contributions of CYP3A4*1B and CYP3A5*3 and of ABCB1 1236C>T, 2677G>T,A, and 3435C>T polymorphisms to Tac response in 89 patients with UC. 21289623 2011
Ulcerative Colitis
CUI: C0009324
Disease: Ulcerative Colitis
0.100 GeneticVariation BEFREE Three-marker (C1236T, G2677T/A, C3435T) and two-marker (C1236T, G2677T/A) haplotype analysis revealed significant associations with UC (TTT, P=0.04; TGT, P=0.01; TT, P=0.01; CT, P=0.03). 19005421 2009
Ulcerative Colitis
CUI: C0009324
Disease: Ulcerative Colitis
0.100 GeneticVariation BEFREE The distribution of the different genotypes of single nucleotide polymorphisms (SNP) G2677T/A and C3435T of MDR1 exons 21 and 26, respectively, was studied in 154 patients (mean age, 44 yr) who had received CsA to treat severe attacks of steroid resistant UC in 11 centers in France and Belgium. 17206635 2007
Ulcerative Colitis
CUI: C0009324
Disease: Ulcerative Colitis
0.100 GeneticVariation BEFREE No significant difference was observed for genotype frequencies for both MDR1 G2677T/A and C3435T polymorphisms on overall disease susceptibility for either CD or UC patients compared with control subjects. 17260353 2007
Ulcerative Colitis
CUI: C0009324
Disease: Ulcerative Colitis
0.100 GeneticVariation BEFREE A meta-analysis of 9 association studies of C3435T showed a significant association of the 3435T allele with UC (OR 1.12; 95% CI 1.02-1.23; P = 0.013) but not with CD. 16633048 2006
Ulcerative Colitis
CUI: C0009324
Disease: Ulcerative Colitis
0.100 GeneticVariation BEFREE Two polymorphisms (C3435T and G2677T/A) of the multidrug resistance 1 gene have been correlated with the altered P-glycoprotein expression and function in humans, and associated with predisposition to ulcerative colitis and Crohn's disease. 16305727 2006
Ulcerative Colitis
CUI: C0009324
Disease: Ulcerative Colitis
0.100 GeneticVariation BEFREE The polymorphism Ala893Ser/Thr (G2677T/A) previously showed significant association with Crohn's disease (CD) and the Ile1145Ile (C3435T) with ulcerative colitis (UC). 16374256 2006
Ulcerative Colitis
CUI: C0009324
Disease: Ulcerative Colitis
0.100 GeneticVariation BEFREE This was a case-control analysis of MDR1 C3435T and G2677T SNPs in a large well-characterized Scottish white cohort (335 with ulcerative colitis [UC], 268 with Crohn's disease [CD], and 370 healthy controls). 15685540 2005
Ulcerative Colitis
CUI: C0009324
Disease: Ulcerative Colitis
0.100 GeneticVariation BEFREE Association between the C3435T MDR1 gene polymorphism and susceptibility for ulcerative colitis. 12512026 2003