rs1045642, ABCB1

N. diseases: 108
Source: ALL
Disease Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Crohn Disease
CUI: C0010346
Disease: Crohn Disease
0.070 GeneticVariation BEFREE Two common single nucleotide polymorphisms (SNPs), C3435T and G2677T/A, thought to alter the function of the corresponding P-glycoprotein, have shown inconsistent associations with CD. 19107781 2009
Crohn Disease
CUI: C0010346
Disease: Crohn Disease
0.070 GeneticVariation BEFREE Three hundred eighty-eight German IBD patients [244 with Crohn's disease (CD), 144 with ulcerative colitis (UC)] and 1,005 German healthy controls were genotyped for the two MDR1 SNPs on positions 2677G>T/A and 3435C>T. 17665184 2008
Crohn Disease
CUI: C0010346
Disease: Crohn Disease
0.070 GeneticVariation BEFREE To investigate the contribution of multidrug resistance 1 (MDR1) gene pharmacogenetics (G2677T/A and C3435T) to the efficacy of azathioprine in inducing remission in patients with Crohn's disease (CD). 17262810 2007
Crohn Disease
CUI: C0010346
Disease: Crohn Disease
0.070 GeneticVariation BEFREE A significant association was found between the MDR1 C3435T polymorphism and patients with ileo-colonic CD (OR = 3.34; 95% CI: 1.34-8.27). 17260353 2007
Crohn Disease
CUI: C0010346
Disease: Crohn Disease
0.070 GeneticVariation BEFREE Two polymorphisms (C3435T and G2677T/A) of the multidrug resistance 1 gene have been correlated with the altered P-glycoprotein expression and function in humans, and associated with predisposition to ulcerative colitis and Crohn's disease. 16305727 2006
Crohn Disease
CUI: C0010346
Disease: Crohn Disease
0.070 GeneticVariation BEFREE A significant association of MDR1 C3435T with CD was observed (CC vs (CT + TT): P = 0.007; OR [95% CI] = 1.58 [1.12-2.23]). 16374256 2006
Crohn Disease
CUI: C0010346
Disease: Crohn Disease
0.070 GeneticVariation BEFREE This was a case-control analysis of MDR1 C3435T and G2677T SNPs in a large well-characterized Scottish white cohort (335 with ulcerative colitis [UC], 268 with Crohn's disease [CD], and 370 healthy controls). 15685540 2005