rs1045642, ABCB1

N. diseases: 108
Source: ALL
Disease Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Epilepsy
CUI: C0014544
Disease: Epilepsy
0.100 GeneticVariation BEFREE All the case-control association researches evaluating the role of MDR1 C3435T polymorphism in childhood epilepsy to antiepileptic drugs were identified. 24553780 2015
Epilepsy
CUI: C0014544
Disease: Epilepsy
0.100 GeneticVariation BEFREE However, ABCB1 rs1045642 increases vulnerability to epilepsy with greater tendency for MTLE-HS in south Indian ancestry from Kerala. 24586633 2015
Epilepsy
CUI: C0014544
Disease: Epilepsy
0.100 GeneticVariation BEFREE In this study, we analyzed whether the three single nucleotide polymorphisms (C1236T, G2677T/A, and C3435T) in the ABCB1 gene were associated with pharmacoresistant epilepsy in a western Chinese pediatric population. 21420937 2011
Epilepsy
CUI: C0014544
Disease: Epilepsy
0.100 GeneticVariation BEFREE No association was found between ABCB1 C3435T polymorphisms and the risk of having epilepsy (odds ratio 1.07, 95% confidence interval 0.76-1.51; p = 0.34). 20491876 2010
Epilepsy
CUI: C0014544
Disease: Epilepsy
0.100 GeneticVariation BEFREE There was no significant relationship between the ABCB1 3435C>T genotype and the rate of recurrence of unprovoked seizures in the three cohorts individually or combined; however the epilepsy syndrome and a greater number of seizures pretreatment was associated with an increased risk of seizure recurrence. 19453704 2010
Epilepsy
CUI: C0014544
Disease: Epilepsy
0.100 GeneticVariation BEFREE We included all published studies until September 2007, in which patients with responsive and unresponsive seizure disorders underwent genotyping for ABCB1 C3435T. 19178561 2009
Epilepsy
CUI: C0014544
Disease: Epilepsy
0.100 GeneticVariation BEFREE Further analysis using a logistic regression model revealed that only 2677G>T and 3435C>T in the ABCB1 gene and their interaction term were associated with drug-resistant epilepsy after adjustment for etiology and epilepsy classification. 17924830 2008
Epilepsy
CUI: C0014544
Disease: Epilepsy
0.100 GeneticVariation BEFREE These findings suggest that C3435T is unlikely to be a marker for epilepsy multidrug resistance. 17460550 2007
Epilepsy
CUI: C0014544
Disease: Epilepsy
0.100 GeneticVariation BEFREE The ABCB1 3435C-->T single-nucleotide polymorphism (SNP) or a three-SNP haplotype containing 3435C-->T has been implicated in multidrug resistance in epilepsy in three retrospective case-control studies, but a further three have failed to replicate the association. 16857572 2006
Epilepsy
CUI: C0014544
Disease: Epilepsy
0.100 GeneticVariation BEFREE The ABCB1 T-129C, C1236T, G2677T/A and C3435T polymorphisms were genotyped in 210 Japanese epileptics who had been prescribed AEDs, including CBZ, for longer than 2 years. 16753003 2006
Epilepsy
CUI: C0014544
Disease: Epilepsy
0.100 GeneticVariation BEFREE Whether the C3435T polymorphism can act as a marker for the natural history of treated epilepsy remains to be determined. 15857428 2005