Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Childhood Acute Lymphoblastic Leukemia
0.100 GeneticVariation BEFREE Metaanalysis results showed no significant association between C3435T polymorphism and pediatric ALL risk (TT vs. CC: odds ratio [OR] = 1.20, 95% confidence interval [CI] = 0.95-1.52; CT vs. CC: OR = 1.00, 95% CI = 0.82-1.23; the dominant model: OR = 1.07, 95% CI = 0.89-1.29; the recessive model: OR = 1.17, 95% CI = 0.84-1.62). 28845766 2017
Childhood Acute Lymphoblastic Leukemia
0.100 GeneticVariation BEFREE C3435T and C1236T MDR1 polymorphism are significantly associated with the high-risk group (OR=2.6, 95%CI=1.164-5.808; P=0.028 and OR=2.231, 95%CI=1.068-4.659; p=0.047, respectively), indicating that both may be candidates for molecular markers in the high-risk group of ALL. 25854371 2015
Childhood Acute Lymphoblastic Leukemia
0.100 GeneticVariation BEFREE This meta-analysis suggests there was no association between MDR1 C3435T polymorphism and children ALL risk in overall populations, but significant association with an increased risk in Asians. 25661341 2015
Childhood Acute Lymphoblastic Leukemia
0.100 GeneticVariation BEFREE There were no association in distribution of genotypes of MDR-1 C3435T polymorphism and the risk of ALL. 23244145 2012
Childhood Acute Lymphoblastic Leukemia
0.100 GeneticVariation BEFREE To determine the influence of the MDR1 C3435T polymorphism on the development of childhood acute lymphoblastic leukemia (ALL), we studied 107 children with ALL and 111 healthy subjects. 19317599 2008
Childhood Acute Lymphoblastic Leukemia
0.100 GeneticVariation BEFREE Overall, the SNPs considered individually or within haplotypes (C1236T-G2677T/A-C3435T) were not significantly associated with childhood ALL. 17548681 2007
Childhood Acute Lymphoblastic Leukemia
0.100 GeneticVariation BEFREE The frequency of the T/T genotype of the 3435C>T was also significantly higher in ALL (29/118 versus 10/96, p=0.006). 17568669 2007
Childhood Acute Lymphoblastic Leukemia
0.100 GeneticVariation BEFREE In a matched case-control study, we investigated the associations between CNS relapse in childhood ALL and the presence of phenotypically relevant single nucleotide polymorphisms within the GSTP1 (codon 105 and 114) and MDR1 genes (ABCB1; coding for Pgp; exon 26, C3435T). 15717687 2005
Childhood Acute Lymphoblastic Leukemia
0.100 GeneticVariation BEFREE In conclusion, the results of the present study provide evidence that C3435T MDR1 polymorphism may involve both the susceptibility to and the clinical outcome of childhood ALL. 15059065 2004
Childhood Acute Lymphoblastic Leukemia
0.100 GeneticVariation BEFREE In conclusion, we do not have reason to assume that the C3435T SNP contributes to drug resistance of ALL and prognosis of ALL patients. 12851703 2003