|
Drug Resistant Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
The results indicate that the C3435T polymorphism of MDR1 gene may be associated with the incidence of DRE observed in the Polish population.
|
27534401 |
2017 |
|
Drug Resistant Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results indicate that ABCB1 C3435T polymorphism, especially TT genotype, plays an important role in refractory epilepsy.
|
28202008 |
2017 |
|
Drug Resistant Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
The relationship between the MDR1 C3435T polymorphism and childhood refractory epilepsy needs further validation.
|
28284049 |
2017 |
|
Drug Resistant Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association between C3435T polymorphism of MDR1 gene and the incidence of drug-resistant epilepsy in the population of Polish children.
|
27391700 |
2016 |
|
Drug Resistant Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
Patients and controls were genotyped for detection of the 3435C>T polymorphism, but the analysis showed no significant association between the CC genotype and the risk of drug-resistant epilepsy.
|
25458099 |
2015 |
|
Drug Resistant Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
The relationship established in a subset of the Chinese population between the MDR1 C3435T polymorphism and refractory epilepsy will guide epilepsy treatment and development of new AEDs.
|
24953225 |
2014 |
|
Drug Resistant Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results did not show a significant association between MDR1 C3435T polymorphism and response to anticonvulsant drugs, suggesting that this polymorphism may not be a risk factor to childhood intractable epilepsy.
|
24553780 |
2014 |
|
Drug Resistant Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
Previous studies have attempted to confirm the association between the ABCB1-C3435T polymorphism and drug-resistant epilepsy and produced discordant findings.
|
24794827 |
2014 |
|
Drug Resistant Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
Multidrug resistance 1 (MDR1) 3435C/T genotyping in childhood drug-resistant epilepsy.
|
23465586 |
2014 |
|
Drug Resistant Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
CYP3A5*3 and C3435T MDR1 polymorphisms in prognostication of drug-resistant epilepsy in children and adolescents.
|
23984379 |
2013 |
|
Drug Resistant Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
ABCC2 rs2273697 (1249G>A) and ABCB1 rs1045642 (3435C>T) polymorphisms were not associated with drug resistant epilepsy.
|
22630058 |
2012 |
|
Drug Resistant Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association analysis of intractable epilepsy with C3435T and G2677T/A ABCB1 gene polymorphisms in Iranian patients.
|
21636342 |
2011 |
|
Drug Resistant Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the present study, we examined the impact of putatively functional polymorphisms 3435C>T and 2677G>T in the ABCB1 gene on the ABCB1 mRNA expression and P-gp content in human brain tissue from epileptogenic foci of the patients with refractory epilepsy.
|
18494787 |
2008 |
|
Drug Resistant Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our findings failed to prove an association between C3435T polymorphism and drug resistance in a sample of Turkish patients with refractory epilepsy who underwent resective brain surgery.
|
18436433 |
2008 |
|
Drug Resistant Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association between ABCB1 C3435T polymorphism and drug-resistant epilepsy in Han Chinese.
|
17521963 |
2007 |
|
Drug Resistant Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
Controversy has surrounded the reported association of the single nucleotide polymorphism (SNP) C3435T of the ATP-binding cassette subfamily B member 1 (ABCB1, MDR1) gene, with refractory epilepsy.
|
17125969 |
2007 |