Lymphoma, Follicular
|
|
0.770 |
GeneticVariation
|
BEFREE |
Multiple follicular lymphoma (FL) susceptibility single-nucleotide polymorphisms in the human leukocyte antigen (HLA) class I and II regions have been identified, including rs6457327, rs3117222, rs2647012, rs10484561, rs9268853 and rs2621416.
|
24304973 |
2014 |
Lymphoma, Follicular
|
|
0.770 |
GeneticVariation
|
BEFREE |
We confirm the association of single nucleotide polymorphisms rs10484561 (P = 3.5 × 10⁻⁹) and rs6457327 (P = .008) with risk of FL and demonstrate that rs6457327 predicts both time to (P = .02) and risk of (P < .01) FL transformation independently of clinical variables, including the Follicular Lymphoma International Prognostic Index.
|
21233317 |
2011 |
Lymphoma, Follicular
|
|
0.770 |
GeneticVariation
|
BEFREE |
In recent genome-wide association studies (GWAS) of FL, several genetic susceptibility loci have been identified on chromosome 6p21.33 (rs6457327) and 6p21.32 (rs10484561, rs2647012) in the human leukocyte antigen class I and class II regions.
|
23025665 |
2012 |
Lymphoma, Follicular
|
|
0.770 |
GeneticVariation
|
BEFREE |
Moreover, in a follow-up analysis of the top 6 FL-associated SNPs in 4,449 cases of other NHL subtypes, rs10484561 was associated with risk of diffuse large B-cell lymphoma (OR(combined) = 1.36, P(combined) = 1.4 × 10(-7)).
|
21533074 |
2011 |
Lymphoma, Follicular
|
|
0.770 |
GeneticVariation
|
GWASDB |
We identified two variants associated with follicular lymphoma at 6p21.32 (rs10484561, combined P = 1.12 x 10(-29) and rs7755224, combined P = 2.00 x 10(-19); r(2) = 1.0), supporting the idea that major histocompatibility complex genetic variation influences follicular lymphoma susceptibility.
|
20639881 |
2010 |
Lymphoma, Follicular
|
|
0.770 |
GeneticVariation
|
BEFREE |
We identified two variants associated with follicular lymphoma at 6p21.32 (rs10484561, combined P = 1.12 x 10(-29) and rs7755224, combined P = 2.00 x 10(-19); r(2) = 1.0), supporting the idea that major histocompatibility complex genetic variation influences follicular lymphoma susceptibility.
|
20639881 |
2010 |
Lymphoma, Follicular
|
|
0.770 |
GeneticVariation
|
BEFREE |
The TAP2 SNP was strongly associated with follicular lymphoma (FL, OR = 1.82, 95%CI 1.46-2.26; p = 6.9 × 10(-8)), and was independent of other known loci (rs10484561 and rs2647012) from this region.
|
22911334 |
2012 |
Lymphoma, Follicular
|
|
0.770 |
GeneticVariation
|
BEFREE |
We investigated the influence on gene expression of three established FL-associated loci-rs10484561, rs2647012, and rs6457327-by measuring their correlation with human-leukocyte-antigen (HLA) expression levels obtained from publicly available RNA-seq expression data sets from lymphoblastoid cell lines.
|
23246294 |
2013 |