rs10484561, None

N. diseases: 6
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Lymphoma, Follicular
CUI: C0024301
Disease: Lymphoma, Follicular
0.770 GeneticVariation BEFREE Multiple follicular lymphoma (FL) susceptibility single-nucleotide polymorphisms in the human leukocyte antigen (HLA) class I and II regions have been identified, including rs6457327, rs3117222, rs2647012, rs10484561, rs9268853 and rs2621416. 24304973 2014
Lymphoma, Follicular
CUI: C0024301
Disease: Lymphoma, Follicular
0.770 GeneticVariation BEFREE We investigated the influence on gene expression of three established FL-associated loci-rs10484561, rs2647012, and rs6457327-by measuring their correlation with human-leukocyte-antigen (HLA) expression levels obtained from publicly available RNA-seq expression data sets from lymphoblastoid cell lines. 23246294 2013
Lymphoma, Follicular
CUI: C0024301
Disease: Lymphoma, Follicular
0.770 GeneticVariation BEFREE The TAP2 SNP was strongly associated with follicular lymphoma (FL, OR = 1.82, 95%CI 1.46-2.26; p = 6.9 × 10(-8)), and was independent of other known loci (rs10484561 and rs2647012) from this region. 22911334 2012
Lymphoma, Follicular
CUI: C0024301
Disease: Lymphoma, Follicular
0.770 GeneticVariation BEFREE In recent genome-wide association studies (GWAS) of FL, several genetic susceptibility loci have been identified on chromosome 6p21.33 (rs6457327) and 6p21.32 (rs10484561, rs2647012) in the human leukocyte antigen class I and class II regions. 23025665 2012
Lymphoma, Follicular
CUI: C0024301
Disease: Lymphoma, Follicular
0.770 GeneticVariation BEFREE We confirm the association of single nucleotide polymorphisms rs10484561 (P = 3.5 × 10⁻⁹) and rs6457327 (P = .008) with risk of FL and demonstrate that rs6457327 predicts both time to (P = .02) and risk of (P < .01) FL transformation independently of clinical variables, including the Follicular Lymphoma International Prognostic Index. 21233317 2011
Lymphoma, Follicular
CUI: C0024301
Disease: Lymphoma, Follicular
0.770 GeneticVariation BEFREE Moreover, in a follow-up analysis of the top 6 FL-associated SNPs in 4,449 cases of other NHL subtypes, rs10484561 was associated with risk of diffuse large B-cell lymphoma (OR(combined)  = 1.36, P(combined)  =  1.4 × 10(-7)). 21533074 2011
Lymphoma, Follicular
CUI: C0024301
Disease: Lymphoma, Follicular
0.770 GeneticVariation GWASDB We identified two variants associated with follicular lymphoma at 6p21.32 (rs10484561, combined P = 1.12 x 10(-29) and rs7755224, combined P = 2.00 x 10(-19); r(2) = 1.0), supporting the idea that major histocompatibility complex genetic variation influences follicular lymphoma susceptibility. 20639881 2010
Lymphoma, Follicular
CUI: C0024301
Disease: Lymphoma, Follicular
0.770 GeneticVariation BEFREE We identified two variants associated with follicular lymphoma at 6p21.32 (rs10484561, combined P = 1.12 x 10(-29) and rs7755224, combined P = 2.00 x 10(-19); r(2) = 1.0), supporting the idea that major histocompatibility complex genetic variation influences follicular lymphoma susceptibility. 20639881 2010
Allergic Reaction
CUI: C1527304
Disease: Allergic Reaction
0.700 GeneticVariation GWASDB A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci. 23817569 2013
Liver carcinoma
CUI: C2239176
Disease: Liver carcinoma
0.700 GeneticVariation GWASDB Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma. 23242368 2013
Mature B-Cell Neoplasm
CUI: C1334633
Disease: Mature B-Cell Neoplasm
0.700 GeneticVariation GWASCAT Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32. 20639881 2010
Diffuse Large B-Cell Lymphoma
CUI: C0079744
Disease: Diffuse Large B-Cell Lymphoma
0.010 GeneticVariation BEFREE Moreover, in a follow-up analysis of the top 6 FL-associated SNPs in 4,449 cases of other NHL subtypes, rs10484561 was associated with risk of diffuse large B-cell lymphoma (OR(combined)  = 1.36, P(combined)  =  1.4 × 10(-7)). 21533074 2011
Adult Diffuse Large B-Cell Lymphoma
CUI: C1332201
Disease: Adult Diffuse Large B-Cell Lymphoma
0.010 GeneticVariation BEFREE Moreover, in a follow-up analysis of the top 6 FL-associated SNPs in 4,449 cases of other NHL subtypes, rs10484561 was associated with risk of diffuse large B-cell lymphoma (OR(combined)  = 1.36, P(combined)  =  1.4 × 10(-7)). 21533074 2011