|
Lupus Erythematosus, Systemic
|
|
0.830 |
GeneticVariation
|
BEFREE |
The IRF5-TNPO3 region showed the strongest association and largest OR for SLE (rs10488631: genomic control-adjusted P [Pgcadj ] = 2.61 × 10(-29), OR 2.12 [95% CI 1.88-2.39]), followed by HLA class II on the DQA2-DQB1 loci (rs9275572: Pgcadj = 1.11 × 10(-16), OR 1.62 [95% CI 1.46-1.80] and rs9271366: Pgcadj = 6.46 × 10(-12), OR 2.06 [95% CI 1.71-2.50]).
|
26606652 |
2016 |
|
Lupus Erythematosus, Systemic
|
|
0.830 |
GeneticVariation
|
BEFREE |
To replicate a single nucleotide polymorphism (SNP) of known genes for lupus (IRF5 rs10488631, PTPN22 rs2476601, BLK rs2736340 and TNFAIP3 rs5029939) and other autoimmune diseases (CD28 rs1980422, IL2RA rs2104286 and KIF5A rs1678542) on a newly studied Egyptian cohort to investigate the genetic disparity with different studied ethnic groups in relation to lupus susceptibility.
|
26092158 |
2015 |
|
Lupus Erythematosus, Systemic
|
|
0.830 |
GeneticVariation
|
GWASCAT |
Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus.
|
26502338 |
2015 |
|
Lupus Erythematosus, Systemic
|
|
0.830 |
GeneticVariation
|
GWASDB |
GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region.
|
24871463 |
2014 |
|
Lupus Erythematosus, Systemic
|
|
0.830 |
GeneticVariation
|
GWASCAT |
GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region.
|
24871463 |
2014 |
|
Lupus Erythematosus, Systemic
|
|
0.830 |
GeneticVariation
|
GWASCAT |
Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production.
|
21408207 |
2011 |
|
Lupus Erythematosus, Systemic
|
|
0.830 |
GeneticVariation
|
GWASDB |
Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production.
|
21408207 |
2011 |
|
Lupus Erythematosus, Systemic
|
|
0.830 |
GeneticVariation
|
BEFREE |
The variants of IRF5 with the highest posterior probabilities (1.00 and 0.71, respectively) of being causal in SLE are a SNP (rs10488631) located 3' of IRF5, and a novel CGGGG insertion-deletion (indel) polymorphism located 64 bp upstream of the first untranslated exon (exon 1A) of IRF5.
|
18063667 |
2008 |
|
Lupus Erythematosus, Systemic
|
|
0.830 |
GeneticVariation
|
GWASDB |
Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX.
|
18204098 |
2008 |
|
Lupus Erythematosus, Systemic
|
|
0.830 |
GeneticVariation
|
GWASCAT |
Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX.
|
18204098 |
2008 |