rs104893877, SNCA

N. diseases: 59
Disease: Impaired cognition ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Impaired cognition
CUI: C0338656
Disease: Impaired cognition
0.030 GeneticVariation BEFREE Here we first provided evidence that RV treatment alleviated motor and cognitive deficits in the A53T α-synuclein mouse model of PD in a dose-dependent manner. 30462117 2018
Impaired cognition
CUI: C0338656
Disease: Impaired cognition
0.030 GeneticVariation BEFREE Transgenic A53T is expressed in the monkey brain and causes age-dependent non-motor symptoms, including cognitive defects and anxiety phenotype, without detectable sleeping disorders. 25552648 2015
Impaired cognition
CUI: C0338656
Disease: Impaired cognition
0.030 GeneticVariation BEFREE Our findings indicate A53T mice develop fine, sensorimotor, and synaptic deficits before the onset of age-related gross motor and cognitive dysfunction. 23936403 2013