rs104893877, SNCA

N. diseases: 59
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Hyperactive behavior
CUI: C0424295
Disease: Hyperactive behavior
0.040 GeneticVariation BEFREE In the present study, we reported transgenic mice with overexpressing human A53T alpha-synuclein, as well as WT mice with high dietary iron displayed hyperactive motor coordination and impaired colonic motility, compared with those with basal dietary iron. 29681846 2018
Hyperactive behavior
CUI: C0424295
Disease: Hyperactive behavior
0.040 GeneticVariation BEFREE The 12-month A53T-transgenic mouse displayed hyperactive movement and anxiolytic-like behaviors with α-synuclein aggregation in midbrain. 27965467 2017
Hyperactive behavior
CUI: C0424295
Disease: Hyperactive behavior
0.040 GeneticVariation BEFREE These results indicate a possible role of the A53T alpha-Syn mutation in anxiety-like and hyperactive behaviors in a PD mouse model, suggesting that these behaviors might be comorbid with this disease. 20077428 2010
Hyperactive behavior
CUI: C0424295
Disease: Hyperactive behavior
0.040 GeneticVariation BEFREE Thus, expression of A</span>53T mutant human alpha-synuclein in mice results in adult-onset hyperactivity associated with D1 receptor and dopamine transporter-mediated alterations in dopamine neurotransmission. 16230020 2006