rs1048943, CYP1A1

N. diseases: 88
Disease: Primary malignant neoplasm ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Primary malignant neoplasm
CUI: C1306459
Disease: Primary malignant neoplasm
0.050 GeneticVariation BEFREE Variant alleles found to increase the risk of developing TCa were CYP1A1*2C (rs1048943), GSTP1 (rs1695), and GSTT1null, especially when in conjunction with a cancer family history and/or a smoking habit. 31107374 2019
Primary malignant neoplasm
CUI: C1306459
Disease: Primary malignant neoplasm
0.050 GeneticVariation BEFREE CYP1A1 I462V polymorphism is associated with reduced genotoxicity in yeast despite positive association with increased cancer risk. 28283091 2017
Primary malignant neoplasm
CUI: C1306459
Disease: Primary malignant neoplasm
0.050 GeneticVariation BEFREE The results of this meta-analysis suggest that CYP1A1 MspI and Ile462Val polymorphisms contribute to increased cancer susceptibility among Asians. 24391993 2013
Primary malignant neoplasm
CUI: C1306459
Disease: Primary malignant neoplasm
0.050 GeneticVariation BEFREE In Caucasians, those with the IIe/Val genotype at CYP1A1 Ile(462)Val locus were at decreased risk of having lung cancer compared to those with the lle/lle genotype, after adjusting for age at diagnosis, sex, pack years of smoking and family history of cancer (OR=0.41 95% Cl 0.19-0.90). 17174438 2007
Primary malignant neoplasm
CUI: C1306459
Disease: Primary malignant neoplasm
0.050 GeneticVariation BEFREE Positive associations between cancer and CYP1A1 alleles, in particular the *2C I462V allele, were found for tissues following the aerodigestive tract. 12872524 2003