Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
A significant genotype and variant allele association was found of rs10490924 in ARMS2/HTRA1 with wet AMD, while the SNPs in CFH, CFB, and C3 were not associated with AMD in the current Pakistani cohort.
|
30895599 |
2019 |
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Before the AMD clinical phenotype is present, those showing normal macular health with the ARMS2 A69S allele demonstrate delayed RMDA.
|
30389424 |
2019 |
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Comparison of ARMS2/LOC387715 A69S and CFH Y402H risk effect in wet-type age-related macular degeneration: a meta-analysis.
|
29423786 |
2019 |
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
However, weak correlations between 10 SNPs (CFH rs1329428 TT genotype, CFH rs3753394 CC genotype and T allele, CFH rs1410996 AA genotype, CFH rs800292 AA genotype, CFH rs800292 A allele, VEGF rs833061 TT genotype and C allele, VEGF rs2010963 CG genotype, VEGFR2 rs1531289 TT genotype, ARMS2 rs10490924 TT genotype, KCTD10 rs238104 GC genotype, rs1531289 T allele and ARMS2 rs10490924 T allele) and AMD were shown.
|
30696427 |
2019 |
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Prevalence of AMD-associated genetic risk variants, complement factor H (CFH) rs1061170, age-related maculopathy susceptibility 2 (ARMS2) rs10490924, component 3 (C3) rs2230199, complement factor B (CFB) rs641153 and superkiller viralicidic activity 2-like (SKIV2L) rs429608 and 4-year progression data in a population-representative cohort (The Irish Longitudinal study on Ageing (TILDA)) were assessed.
|
29453225 |
2018 |
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Exploring the association of rs10490924 polymorphism with age-related macular degeneration: An in silico approach.
|
29316486 |
2018 |
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Age and the T allele of ARMS2 A69S are the risk factors requiring retreatments, leading to poor visual change in eyes with exudative AMD following the initial 3-monthly IVR.
|
29045945 |
2018 |
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Comparison of above-mentioned ORs revealed statistically higher values for GT and TT genotypes of ARMS2 A69S compared with CFH Y402H genotypes (p = 0.011, p = 0.014, respectively).Our analysis showed stronger contribution of ARMS2 in AMD with RPD group versus AMD without RPD group, in comparison with CFH genotypes.
|
28593728 |
2018 |
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Blood samples from all subjects were genotyped for major age-related macular degeneration (AMD)-associated single nucleotide polymorphisms (SNPs) the major AMD-associated SNPs; CFH Y402H rs1061170, CFH I62V rs800292, ARMS2 A69S rs10490924.
|
30596689 |
2018 |
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Sub-analysis demonstrated that women with ARMS2 A69S polymorphisms had a stronger risk for early AMD (OR: 3.25, 95% CI: 2.10-5.04) than men (OR: 1.65, 95% CI: 1.02-2.69).
|
29335418 |
2018 |
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
We found associations with nvAMD for <i>CFHY402H</i> variant (rs1061170) (OR=1.99, 95% CI 1.67 to 2.37, P=10<sup>-6</sup>), <i>ARMS2</i> (rs10490924) (OR=2.94, 95% CI 2.45 to 3.52, P=10<sup>-9</sup>), <i>C2</i> (rs547154) (OR=0.67, 95% CI 0.53 to 0.85, P=0.01), <i>ABCA1</i> (rs1883025) (OR=0.77, 95% CI 0.65 to 0.92, P=0.04) and an SNP near <i>VEGFA</i> (rs4711751) (OR=0.64, 95% CI 0.54 to 0.77, P=10<sup>-3</sup>).
|
29259020 |
2018 |
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
To evaluate effect modification, the association between tertiles (T) of xanthophyll intake and AMD was stratified by complement factor H (CFH) rs1061170 and age-related maculopathy susceptibility 2 (ARMS2) rs10490924 genotypes, as well as by median cutpoints of HDL biomarkers.
|
28332910 |
2017 |
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Exploring the association of rs10490924 polymorphism with age-related macular degeneration: An in silico approach.
|
28915445 |
2017 |
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
We confirmed the association of age-related maculopathy susceptibility 2 (ARMS2) rs10490924 (P=7.38 × 10<sup>-17</sup>), HTRA1 rs11200638 (P=5.47 × 10<sup>-17</sup>) and complement factor H gene (CFH) rs800292 (P=2.53 × 10<sup>-8</sup>) with neovascular AMD, all loci passing the genome-wide significance level (P<5.22 × 10<sup>-8</sup>).
|
28703135 |
2017 |
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
The ARMS2 protein is absent in monocytes and also in microglia cells, derived from patients homozygous for the ARMS2 AMD risk variant (rs10490924).
|
28086806 |
2017 |
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
GWASCAT |
We confirmed the association of age-related maculopathy susceptibility 2 (ARMS2) rs10490924 (P=7.38 × 10<sup>-17</sup>), HTRA1 rs11200638 (P=5.47 × 10<sup>-17</sup>) and complement factor H gene (CFH) rs800292 (P=2.53 × 10<sup>-8</sup>) with neovascular AMD, all loci passing the genome-wide significance level (P<5.22 × 10<sup>-8</sup>).
|
28703135 |
2017 |
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Logistic regression analysis revealed a relationship between the rs10490924 polymorphism and AMD in the Turkish population.
|
28128407 |
2017 |
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
We and others have previously identified several polymorphisms on chromosome 10q26 (HTRA1 rs11200638 as well as LOC387715 rs10490924 and c.372_815del443ins54) associated with AMD.
|
27841854 |
2017 |
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
With regard to <i>ARMS2</i>, the variation is most pronounced in testes: homozygotes with the high-AMD-risk haplotype express <i>ARMS2</i> at lower levels than homozygotes with the low-AMD-risk haplotype; expression in heterozygotes falls in between (rs10490924 effect size -0.79, p = 7.5 x 10<sup>-24</sup>).
|
28659708 |
2017 |
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Association of combined cigarette smoking and ARMS2/LOC387715 A69S polymorphisms with age-related macular degeneration: A meta-analysis.
|
28095100 |
2017 |
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Odds ratios, especially for the main risk polymorphisms in ARMS2 (rs10490924) and CFH (rs1061170), gained with increasing disease severity and bilateralism (exemplarily: rs1061170: unilateral early AMD: OR = 1.18; bilateral early AMD: OR = 1.20; unilateral intermediate AMD: OR = 1.28; bilateral intermediate AMD: OR = 1.39, unilateral geographic atrophy (GA): OR = 1.50; bilateral GA: OR = 1.71).
|
27257685 |
2016 |
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Patients with GA were significantly older, with a higher prevalence of reticular pseudodrusen, bilateral involvement of advanced AMD and T-allele frequency of ARMS2 A69S compared with those with typical AMD and PCV; although there were no differences in the genetic and clinical characteristics among patients with GA and RAP.
|
26918864 |
2016 |
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
The aim of this study was to investigate the association between the genotype of ARMS2 rs10490924 polymorphism and IVR treatment responsiveness in patients with neovascular AMD.
|
28002601 |
2016 |
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Association of Combined Complement Factor H Y402H and ARMS/LOC387715 A69S Polymorphisms with Age-related Macular Degeneration: A Meta-analysis.
|
27269047 |
2016 |
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Patients were genotyped to identify major single nucleotide polymorphisms associated with AMD (CFH Y402, CFH I62V, and ARMS2 A69S).
|
27521170 |
2016 |