rs10498676, ELOVL2

N. diseases: 3
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Phospholipid measurement
CUI: C0202177
Disease: Phospholipid measurement
0.700 GeneticVariation GWASDB Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium. 21829377 2011
Autistic Disorder
CUI: C0004352
Disease: Autistic Disorder
0.010 GeneticVariation BEFREE The A/A genotype of rs10498676 was correlated with a decline in the Autism Diagnostic Interview-Revised communication (verbal and nonverbal) domain. 30180836 2018
Autism Spectrum Disorders
CUI: C1510586
Disease: Autism Spectrum Disorders
0.010 GeneticVariation BEFREE FADS2 rs526126 and ELOVL2 rs10498676 were associated with decreased ASD risk in recessive model (OR = 0.07, 95% CI = 0.02-0.22, p<sub>FDR</sub> < 0.01; OR = 0.56, 95% CI = 0.35-0.89, p<sub>FDR</sub> = 0.042), while ELOVL2 rs17606561, rs3756963, and rs9468304 were associated with increased ASD risk in overdominant model (OR = 1.63, 95% CI = 1.12-2.36, p<sub>FDR</sub> = 0.036; OR = 1.64, 95% CI = 1.14-2.37, p<sub>FDR</sub> = 0.039; OR = 1.75, 95% CI = 1.22-2.50, p<sub>FDR</sub> = 0.017). 30180836 2018