|
Migraine Disorders
|
|
0.010 |
GeneticVariation
|
BEFREE |
Similarly, there was no association between the rs1051730 T allele and migraine or non-migrainous headache versus no headache.
|
29747220 |
2018 |
|
Headache
|
|
0.010 |
GeneticVariation
|
BEFREE |
There was no strong evidence that the rs1051730 T allele was associated with headache in ever smokers (odds ratio 0.99, 95% confidence interval 0.95-1.02).
|
29747220 |
2018 |
|
Hay fever
|
|
0.010 |
GeneticVariation
|
BEFREE |
We examined the causal effect of smoking on hay fever and asthma by using the smoking-associated single nucleotide polymorphism (SNP) rs16969968/rs1051730.
|
28533558 |
2017 |
|
melanoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Among 16 SNPs, three (rs16969968 [A], rs1051730 [A] and rs2036534 [C] in the 15q25.1 region) reached significance for association with melanoma risk in men (0.01 < = P values < = 0.02; 0.85 < = Odds Ratios (ORs) <= 1.20).
|
27344179 |
2016 |
|
Hypertensive disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, in Mendelian randomization analyses among current smokers, although each smoking increasing allele of rs16969968/rs1051730 was associated with higher resting heart rate (0.36 bpm/allele; 95% confidence interval 0.18; 0.54), there was no strong association with diastolic blood pressure, systolic blood pressure, or hypertension.
|
26538566 |
2015 |
|
Cannabis Abuse
|
|
0.010 |
GeneticVariation
|
BEFREE |
Rs16969968 in CHRNA5 (and its proxy, rs1051730 in CHRNA3) and rs1451240, a proxy for rs13280604 in CHRNB3, were associated with CPD after Bonferroni correction (p<0.006). rs1451240 was also associated with DSM-IV cannabis abuse/dependence.
|
25770649 |
2015 |
|
Schizophrenia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Odds ratios per rs1051730 allele for schizophrenia and antipsychotic medication use in ever-smokers in the general population were 1.22 (95% CI: 0.84-1.79) and 1.06 (1.00-1.12).
|
26054357 |
2015 |
|
Obesity
|
|
0.010 |
GeneticVariation
|
BEFREE |
Mendelian randomisation meta-analyses using a genetic variant (rs16969968/rs1051730 in the CHRNA5-CHRNA3-CHRNB4 gene region) as a proxy for smoking heaviness, of the associations of smoking heaviness with a range of adiposity phenotypes.
|
26264275 |
2015 |
|
Mixed anxiety and depressive disorder
|
|
0.010 |
GeneticVariation
|
BEFREE |
Mendelian randomisation meta-analyses using a genetic variant (rs16969968/rs1051730) as a proxy for smoking heaviness, and observational meta-analyses of the associations of smoking status and smoking heaviness with depression, anxiety and psychological distress.
|
25293386 |
2014 |
|
psychological distress
|
|
0.010 |
GeneticVariation
|
BEFREE |
In Mendelian randomisation analyses, there was no strong evidence that the minor allele of rs16969968/rs1051730 was associated with depression (OR=1.00, 95% CI 0.95 to 1.05), anxiety (OR=1.02, 95% CI 0.97 to 1.07) or psychological distress (OR=1.02, 95% CI 0.98 to 1.06) in current smokers.
|
25293386 |
2014 |
|
Depressive disorder
|
|
0.010 |
GeneticVariation
|
BEFREE |
As there was no association of the smoking-related rs1051730 SNP with anxiety and depression among smokers, the results suggest that smoking is not a cause of anxiety and depression.
|
22687325 |
2013 |
|
Mental Depression
|
|
0.010 |
GeneticVariation
|
BEFREE |
As there was no association of the smoking-related rs1051730 SNP with anxiety and depression among smokers, the results suggest that smoking is not a cause of anxiety and depression.
|
22687325 |
2013 |
|
Drug habituation
|
|
0.010 |
GeneticVariation
|
BEFREE |
We assessed the effect of nicotine on PPI, startle reactivity, and habituation in 52 healthy nonsmoking volunteers genotyped for CHRNA3 rs1051730 in a double-blind, placebo-controlled, counterbalanced, within-subjects design.
|
23604333 |
2013 |
|
Depressed mood
|
|
0.010 |
GeneticVariation
|
BEFREE |
As there was no association of the smoking-related rs1051730 SNP with anxiety and depression among smokers, the results suggest that smoking is not a cause of anxiety and depression.
|
22687325 |
2013 |
|
Carcinoma of bladder
|
|
0.010 |
GeneticVariation
|
BEFREE |
Here, we investigated the roles of variations at 5p15 (rs401681, rs402710, rs2736098 and rs2736100) and 15q25 (rs1051730 and rs8034191) in bladder cancer etiology in two case-control studies conducted separately in Los Angeles County, CA, USA (498 cases and 588 controls) and in Shanghai, China (506 cases and 530 controls).
|
21081471 |
2011 |
|
Malignant neoplasm of urinary bladder
|
|
0.010 |
GeneticVariation
|
BEFREE |
Here, we investigated the roles of variations at 5p15 (rs401681, rs402710, rs2736098 and rs2736100) and 15q25 (rs1051730 and rs8034191) in bladder cancer etiology in two case-control studies conducted separately in Los Angeles County, CA, USA (498 cases and 588 controls) and in Shanghai, China (506 cases and 530 controls).
|
21081471 |
2011 |
|
Lung diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
Multivariate logistic regression adjusting for gender, age, education, leisure-time physical activity, and personal history of cardiovascular or lung disease showed rs1051730 to be associated with higher smoking dependence (odds ratio [OR] and 95% CI for each additional A-allele: 1.38 [1.11-1.72] for smoking more than 20 cigarette equivalents/day; 1.31 [1.00-1.71] for an HSI ≥5 and 1.32 [1.05-1.65] for smoking 5 min after waking up) and borderline associated with difficulty to quit (OR = 1.29 [0.98-1.70]), but this relationship was no longer significant after adjusting for nicotine dependence.
|
21511889 |
2011 |
|
Squamous cell carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the multivariate linear regression model, both rs1051730 and smoking were significant predictors for the size of sq</span>uamous carcinomas.
|
21645942 |
2011 |
|
Malignant neoplasm of pancreas
|
|
0.010 |
GeneticVariation
|
BEFREE |
We found that 2 risk single nucleotide polymorphisms reported in the lung cancer GWA studies-rs8034191: A>G and rs1051730: G>A, located in this 15q24-25.1 region-were not associated with risk of pancreatic cancer.
|
21697764 |
2011 |
|
Airway Obstruction
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our findings suggest that rs1051730 in CHRNA is a susceptibility variant for COPD, in terms of both airway obstruction and parenchyma destruction.
|
22176972 |
2011 |
|
Bladder Neoplasm
|
|
0.010 |
GeneticVariation
|
BEFREE |
Here, we investigated the roles of variations at 5p15 (rs401681, rs402710, rs2736098 and rs2736100) and 15q25 (rs1051730 and rs8034191) in bladder cancer etiology in two case-control studies conducted separately in Los Angeles County, CA, USA (498 cases and 588 controls) and in Shanghai, China (506 cases and 530 controls).
|
21081471 |
2011 |
|
Pancreatic carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We found that 2 risk single nucleotide polymorphisms reported in the lung cancer GWA studies-rs8034191: A>G and rs1051730: G>A, located in this 15q24-25.1 region-were not associated with risk of pancreatic cancer.
|
21697764 |
2011 |
|
Bronchial Obstruction
|
|
0.010 |
GeneticVariation
|
BEFREE |
The rs1051730 A-allele correlated with reduced FEV(1) and with increased susceptibility for bronchial obstruction with a pooled odds ratio (OR) of 1.33 (95% confidence interval [CI] = 1.11-1.61; P = 0.0026).
|
20007924 |
2010 |
|
Metastatic non-small cell lung cancer
|
|
0.010 |
GeneticVariation
|
BEFREE |
CHRNA3 (rs1051730) genotyping can improve customized chemotherapy based on tumor assessment of ERCC1 mRNA in stage IV NSCLC with PS 0.
|
19733931 |
2010 |
|
Pulmonary Emphysema
|
|
0.010 |
GeneticVariation
|
BEFREE |
Consistently, the rs1051730 A-allele conferred increased risk for emphysema as assessed by CT (P = 0.0097 and P = 0.019), with a pooled OR of 1.39 (CI = 1.15-1.68; P = 0.00051).
|
20007924 |
2010 |