|
Primary malignant neoplasm of lung
|
|
0.080 |
GeneticVariation
|
BEFREE |
In the analysis of Tyr113His, the His/His genotype carriers were found to have 29 % higher risk of lung cancer compared to the Tyr/Tyr carriers (His/His vs. Tyr/Tyr, odds ratio, 1.29, 95 % confidence interval, 1.06-1.58).
|
25312477 |
2015 |
|
Malignant neoplasm of lung
|
|
0.080 |
GeneticVariation
|
BEFREE |
In the analysis of Tyr113His, the His/His genotype carriers were found to have 29 % higher risk of lung cancer compared to the Tyr/Tyr carriers (His/His vs. Tyr/Tyr, odds ratio, 1.29, 95 % confidence interval, 1.06-1.58).
|
25312477 |
2015 |
|
Carcinoma of lung
|
|
0.080 |
GeneticVariation
|
BEFREE |
In the analysis of Tyr113His, the His/His genotype carriers were found to have 29 % higher risk of lung cancer compared to the Tyr/Tyr carriers (His/His vs. Tyr/Tyr, odds ratio, 1.29, 95 % confidence interval, 1.06-1.58).
|
25312477 |
2015 |
|
Malignant neoplasm of lung
|
|
0.080 |
GeneticVariation
|
BEFREE |
Our meta-analysis suggested that the EPHX1 Tyr113His polymorphism may be a risk factor for lung cancer in Asians, whereas it may be a decreased risk factor among Caucasians.
|
25222243 |
2014 |
|
Primary malignant neoplasm of lung
|
|
0.080 |
GeneticVariation
|
BEFREE |
Our meta-analysis suggested that the EPHX1 Tyr113His polymorphism may be a risk factor for lung cancer in Asians, whereas it may be a decreased risk factor among Caucasians.
|
25222243 |
2014 |
|
Carcinoma of lung
|
|
0.080 |
GeneticVariation
|
BEFREE |
Our meta-analysis suggested that the EPHX1 Tyr113His polymorphism may be a risk factor for lung cancer in Asians, whereas it may be a decreased risk factor among Caucasians.
|
25222243 |
2014 |
|
Primary malignant neoplasm of lung
|
|
0.080 |
GeneticVariation
|
BEFREE |
These findings suggest that the exon 3 Tyr113His and exon 4 His139Arg polymorphisms of EPHXI may be associated with a increased risk of lung cancer and a worse prognosis.
|
21302624 |
2011 |
|
Primary malignant neoplasm of lung
|
|
0.080 |
GeneticVariation
|
BEFREE |
MDR analysis identified two distinct predictor models for the risk of lung cancer in smokers (tobacco chewing, EPHX1 Tyr113His, and SULT1A1 Arg213His) and non-smokers (CYP1A1*2A, GSTP1 Ile105Val and SULT1A1 Arg213His) with testing balance accuracy (TBA) of 0.6436 and 0.6677 respectively.
|
22206016 |
2011 |
|
Carcinoma of lung
|
|
0.080 |
GeneticVariation
|
BEFREE |
A comprehensive systematic review and meta-analysis was performed of available studies on these two polymorphisms and cancer risk published up to November 2010, consisting of 84 studies (31144 cases and 42439 controls) for Tyr113His and 77 studies (28496 cases and 38506 controls) for His139Arg primarily focused on lung cancer, upper aerodigestive tract (UADT) cancers (including oral, pharynx, larynx and esophagus cancers), colorectal cancer or adenoma, bladder cancer and breast cancer.
|
21445251 |
2011 |
|
Carcinoma of lung
|
|
0.080 |
GeneticVariation
|
BEFREE |
These findings suggest that the exon 3 Tyr113His and exon 4 His139Arg polymorphisms of EPHXI may be associated with a increased risk of lung cancer and a worse prognosis.
|
21302624 |
2011 |
|
Malignant neoplasm of lung
|
|
0.080 |
GeneticVariation
|
BEFREE |
MDR analysis identified two distinct predictor models for the risk of lung cancer in smokers (tobacco chewing, EPHX1 Tyr113His, and SULT1A1 Arg213His) and non-smokers (CYP1A1*2A, GSTP1 Ile105Val and SULT1A1 Arg213His) with testing balance accuracy (TBA) of 0.6436 and 0.6677 respectively.
|
22206016 |
2011 |
|
Primary malignant neoplasm of lung
|
|
0.080 |
GeneticVariation
|
BEFREE |
Binary logistic regression analysis showed association of polymorphism Tyr113His with increased risk of lung cancer (OR = 2.2, 95% CI = 1.2-4.0, p < .05).
|
21649467 |
2011 |
|
Carcinoma of lung
|
|
0.080 |
GeneticVariation
|
BEFREE |
Binary logistic regression analysis showed association of polymorphism Tyr113His with increased risk of lung cancer (OR = 2.2, 95% CI = 1.2-4.0, p < .05).
|
21649467 |
2011 |
|
Malignant neoplasm of lung
|
|
0.080 |
GeneticVariation
|
BEFREE |
Binary logistic regression analysis showed association of polymorphism Tyr113His with increased risk of lung cancer (OR = 2.2, 95% CI = 1.2-4.0, p < .05).
|
21649467 |
2011 |
|
Malignant neoplasm of lung
|
|
0.080 |
GeneticVariation
|
BEFREE |
These findings suggest that the exon 3 Tyr113His and exon 4 His139Arg polymorphisms of EPHXI may be associated with a increased risk of lung cancer and a worse prognosis.
|
21302624 |
2011 |
|
Malignant neoplasm of lung
|
|
0.080 |
GeneticVariation
|
BEFREE |
A comprehensive systematic review and meta-analysis was performed of available studies on these two polymorphisms and cancer risk published up to November 2010, consisting of 84 studies (31144 cases and 42439 controls) for Tyr113His and 77 studies (28496 cases and 38506 controls) for His139Arg primarily focused on lung cancer, upper aerodigestive tract (UADT) cancers (including oral, pharynx, larynx and esophagus cancers), colorectal cancer or adenoma, bladder cancer and breast cancer.
|
21445251 |
2011 |
|
Primary malignant neoplasm of lung
|
|
0.080 |
GeneticVariation
|
BEFREE |
A comprehensive systematic review and meta-analysis was performed of available studies on these two polymorphisms and cancer risk published up to November 2010, consisting of 84 studies (31144 cases and 42439 controls) for Tyr113His and 77 studies (28496 cases and 38506 controls) for His139Arg primarily focused on lung cancer, upper aerodigestive tract (UADT) cancers (including oral, pharynx, larynx and esophagus cancers), colorectal cancer or adenoma, bladder cancer and breast cancer.
|
21445251 |
2011 |
|
Carcinoma of lung
|
|
0.080 |
GeneticVariation
|
BEFREE |
MDR analysis identified two distinct predictor models for the risk of lung cancer in smokers (tobacco chewing, EPHX1 Tyr113His, and SULT1A1 Arg213His) and non-smokers (CYP1A1*2A, GSTP1 Ile105Val and SULT1A1 Arg213His) with testing balance accuracy (TBA) of 0.6436 and 0.6677 respectively.
|
22206016 |
2011 |
|
Carcinoma of lung
|
|
0.080 |
GeneticVariation
|
BEFREE |
However, this study provides some support for the T-Allel of GPX1(Pro200Leu) and the C-Allele of EPHX1(His113Tyr) to play a protective role in early onset lung cancer susceptibility.
|
18298806 |
2008 |
|
Malignant neoplasm of lung
|
|
0.080 |
GeneticVariation
|
BEFREE |
However, this study provides some support for the T-Allel of GPX1(Pro200Leu) and the C-Allele of EPHX1(His113Tyr) to play a protective role in early onset lung cancer susceptibility.
|
18298806 |
2008 |
|
Primary malignant neoplasm of lung
|
|
0.080 |
GeneticVariation
|
BEFREE |
However, this study provides some support for the T-Allel of GPX1(Pro200Leu) and the C-Allele of EPHX1(His113Tyr) to play a protective role in early onset lung cancer susceptibility.
|
18298806 |
2008 |
|
Malignant neoplasm of lung
|
|
0.080 |
GeneticVariation
|
BEFREE |
We investigated the roles of EPHX1 Tyr113His and His139Arg polymorphisms in lung cancer susceptibility in a Finnish study population comprising of 230 lung cancer cases and a large control group (n=2105).
|
16005144 |
2006 |
|
Primary malignant neoplasm of lung
|
|
0.080 |
GeneticVariation
|
BEFREE |
We investigated the roles of EPHX1 Tyr113His and His139Arg polymorphisms in lung cancer susceptibility in a Finnish study population comprising of 230 lung cancer cases and a large control group (n=2105).
|
16005144 |
2006 |
|
Carcinoma of lung
|
|
0.080 |
GeneticVariation
|
BEFREE |
We investigated the roles of EPHX1 Tyr113His and His139Arg polymorphisms in lung cancer susceptibility in a Finnish study population comprising of 230 lung cancer cases and a large control group (n=2105).
|
16005144 |
2006 |
|
Colorectal Carcinoma
|
|
0.070 |
GeneticVariation
|
BEFREE |
We investigated the risk of colorectal cancer in relation to the EPHX1 Y113H and H139R polymorphisms and assessed effect modifications of cigarette smoking and the other covariates.
|
22415791 |
2013 |