Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
MYELOPROLIFERATIVE DISORDER, CHRONIC, WITH EOSINOPHILIA
0.040 GeneticVariation BEFREE The purpose of this study is to investigate the effect of first-line and second-line EGFR-tyrosine kinase inhibitors (TKIs) in the treatment of NSCLC with MPEs harboring exon 19 deletion and L858R mutation. 28618947 2017
MYELOPROLIFERATIVE DISORDER, CHRONIC, WITH EOSINOPHILIA
0.040 GeneticVariation BEFREE The purpose of this study was to clarify the relationship between the EGFR-L858R mutation and cancer cell invasion ability and to investigate the molecular mechanisms involved in the formation of MPE. 26338423 2015
MYELOPROLIFERATIVE DISORDER, CHRONIC, WITH EOSINOPHILIA
0.040 GeneticVariation BEFREE Patients in stage IV lung adenocarcinoma with MPEs at initial diagnosis have shorter overall survival and higher EGFR mutation rate, especially for L858R, than patients who develop MPEs following disease progression. 23018906 2013
MYELOPROLIFERATIVE DISORDER, CHRONIC, WITH EOSINOPHILIA
0.040 GeneticVariation BEFREE Among these MPE samples, EGFR mutations were much more frequently identified by sequencing using RNA than by sequencing and mass-spectrometric analysis from genomic DNA (for all mutations, 67.3 versus 44.7 and 46.7%; for L858R or exon 19 deletions, 61.3 versus 41.3 and 46.7%, respectively). 21719485 2012