|
gliosarcoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We histopathologically identified 14 glioblastomas, 4 grade III astrocytomas and 1 gliosarcoma.Two cases showed a H3F3A K27M mutation.
|
29809131 |
2019 |
|
Childhood Gliosarcoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We histopathologically identified 14 glioblastomas, 4 grade III astrocytomas and 1 gliosarcoma.Two cases showed a H3F3A K27M mutation.
|
29809131 |
2019 |
|
Adult Gliosarcoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We histopathologically identified 14 glioblastomas, 4 grade III astrocytomas and 1 gliosarcoma.Two cases showed a H3F3A K27M mutation.
|
29809131 |
2019 |
|
Malignant Glioma
|
|
0.010 |
GeneticVariation
|
BEFREE |
A case report of adult cerebellar high-grade glioma with H3.1 K27M mutation: a rare example of an H3 K27M mutant cerebellar tumor.
|
29264735 |
2018 |
|
High grade glioma
|
|
0.010 |
GeneticVariation
|
BEFREE |
A case report of adult cerebellar high-grade glioma with H3.1 K27M mutation: a rare example of an H3 K27M mutant cerebellar tumor.
|
29264735 |
2018 |
|
High Grade Astrocytic Tumor
|
|
0.010 |
GeneticVariation
|
BEFREE |
We herein present the case of an adult cerebellar high-grade astrocytic tumor with H3.1 K27M mutation in a 45-year-old man, which also involvedTP53 mutation and was immunonegative for ATRX.
|
29264735 |
2018 |
|
Carcinogenesis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Frequent mutations in chromatin-modifier genes were identified including, noticeably, a truncating mutation in SETD2 (n = 4), which resulted in loss of H3K36 trimethylation and was mutually exclusive with H3F3A K27M mutation (n = 3), suggesting that epigenetic dysregulation may lead to DCG tumorigenesis.
|
28852847 |
2017 |
|
Brain Stem Glioblastoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In addition, we were able to discern the H3F3A K27M mutation in a newly obtained pediatric brainstem glioblastoma sample whose H3.3 status was not known previously, and in three other DIPG samples as well as paraffin embedded samples.
|
26376656 |
2016 |
|
Monosomy
|
|
0.010 |
GeneticVariation
|
BEFREE |
In this series, histone H3-K27M mutation was mutually exclusive with IDH1 mutation and EGFR amplification, rarely co-occurred with BRAF-V600E mutation, and was commonly associated with p53 overexpression, ATRX loss (except in pontine gliomas), and monosomy 10.
|
26517431 |
2016 |
|
Neoplasm Metastasis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We found conservation of heterozygous K27M mutations in H3F3A (n = 4) or HIST1H3B (n = 3) across all primary, contiguous, and metastatic tumor sites in all DIPGs.
|
26727948 |
2016 |
|
Malignant transformation
|
|
0.010 |
GeneticVariation
|
BEFREE |
This report demonstrates minute neuroradiological and pathological features of malignant transformation from thalamic low grade glioma with H3F3A K27M mutation.
|
27392443 |
2016 |
|
Low grade glioma
|
|
0.010 |
GeneticVariation
|
BEFREE |
This report demonstrates minute neuroradiological and pathological features of malignant transformation from thalamic low grade glioma with H3F3A K27M mutation.
|
27392443 |
2016 |
|
Central Nervous System Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
H3F3A K27M mutation in pediatric CNS tumors: a marker for diffuse high-grade astrocytomas.
|
23429371 |
2013 |
|
Anaplastic astrocytoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The K27M mutation occurred in 35 of 129 glioblastomas (27.1%) and in 5 of 28 (17.9%) anaplastic astrocytomas.
|
23429371 |
2013 |
|
Brain Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
Diffuse intrinsic pontine gliomas (DIPGs) are highly aggressive pediatric brain tumors that are characterized by a recurrent mutation (K27M) within the histone H3 encoding genes H3F3A or HIST1H3A/B/C.
|
30943283 |
2019 |
|
Ganglioglioma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Here, we report a rare patient with spinal ganglioglioma carrying an H3 K27M mutation.
|
29675936 |
2018 |
|
Ganglioglioma
|
|
0.020 |
GeneticVariation
|
BEFREE |
We demonstrate in this first series of midline GGs that the H3 K27M mutation can occur in association with the BRAF V600E mutation in grade I glioneuronal tumors.
|
27984673 |
2018 |
|
Childhood Ganglioglioma
|
|
0.020 |
GeneticVariation
|
BEFREE |
We demonstrate in this first series of midline GGs that the H3 K27M mutation can occur in association with the BRAF V600E mutation in grade I glioneuronal tumors.
|
27984673 |
2018 |
|
Brain Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
These data suggest that H3 K27M cannot be considered a specific hallmark of grade IV diffuse gliomas and highlight the importance of integrated histomolecular diagnosis in paediatric brain tumors.
|
27984673 |
2018 |
|
Cerebellar Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
A case report of adult cerebellar high-grade glioma with H3.1 K27M mutation: a rare example of an H3 K27M mutant cerebellar tumor.
|
29264735 |
2018 |
|
Childhood Ganglioglioma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Here, we report a rare patient with spinal ganglioglioma carrying an H3 K27M mutation.
|
29675936 |
2018 |
|
Cerebellar Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
More cerebellar tumors need to be tested for H3 K27M mutations to clarify the clinical and histopathological spectra of this tumor.
|
28547652 |
2017 |
|
Adult Glioblastoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
Histologically, the tumor was considered to be glioblastoma; however, a part of the tumor exhibiting low proliferative activity appeared to be consistent with long-standing H3 K27M-mutant tumors in the literature.Another case was a 69-year-old male.
|
28547652 |
2017 |
|
Childhood Glioblastoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
Histologically, the tumor was considered to be glioblastoma; however, a part of the tumor exhibiting low proliferative activity appeared to be consistent with long-standing H3 K27M-mutant tumors in the literature.Another case was a 69-year-old male.
|
28547652 |
2017 |
|
Adult Glioblastoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
Histone H3.3 (H3F3A) mutation in the codon for lysine 27 (K27M) has been found as driver mutations in pediatric glioblastoma and has been suggested to play critical roles in the pathogenesis of thalamic gliomas and diffuse intrinsic pontine gliomas.
|
27392443 |
2016 |