rs1057519903, H3-3A

N. diseases: 28
Disease: Glioma ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Glioma
CUI: C0017638
Disease: Glioma
0.050 GeneticVariation BEFREE No significant prognostic value was observed for grade, even after regrading H3F3A K27M-mutated midline glioma as grade IV (WHO 2016). 31419298 2020
Glioma
CUI: C0017638
Disease: Glioma
0.050 GeneticVariation BEFREE Whereas both H3F3A K27M and BRAF V600E have been reported as poor prognostic markers in pediatric glioma, our case, along with several other reported cases, suggests that the coexistence of these two mutations might not indicate poor prognosis. 31254135 2019
Glioma
CUI: C0017638
Disease: Glioma
0.050 GeneticVariation BEFREE Despite the presence of H3 K27M mutations, these cases should not be graded and treated as grade IV tumors because they have a better spontaneous outcome than classic diffuse midline H3 K27M-mutant glioma. 27984673 2018
Glioma
CUI: C0017638
Disease: Glioma
0.050 GeneticVariation BEFREE Five (12 %) low grade and 11 (50 %) high grade gliomas were positive for the H3F3A/HIST1H3B K27M (H3K27M) mutation. 27577993 2016
Glioma
CUI: C0017638
Disease: Glioma
0.050 GeneticVariation BEFREE Pediatric thalamic glioma with H3F3A K27M mutation, which was detected before and after malignant transformation: a case report. 27392443 2016