|
Bacterial Infections
|
|
0.010 |
GeneticVariation
|
BEFREE |
A case-control method (488 septic patients and 527 healthy individuals) was carried out in this study to investigate the genetic relationship between CFH polymorphisms (rs3753394 C/T, rs1065489 G/T and rs1061170 C/T) and susceptibility to sepsis caused by bacterial infections in Chinese Han populations.
|
31525397 |
2020 |
|
Acute central serous chorioretinopathy
|
|
0.010 |
GeneticVariation
|
BEFREE |
Three single nucleotide polymorphisms in the CFH gene were significantly associated with aCSC: rs800292 (P = 0.003, odds ratio = 1.53 [95% confidence interval = 1.15-2.03]), rs1061170 (P = 0.002, odds ratio = 0.64 [95% confidence interval = 0.48-0.86]), and rs1329428 (P = 5.87 × 10, odds ratio = 1.83 [95% confidence interval = 1.40-2.38]).
|
30300269 |
2019 |
|
Stargardt's disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
CFH Y402H polymorphism in Italian patients with age-related macular degeneration, retinitis pigmentosa, and Stargardt disease.
|
30285522 |
2018 |
|
Thrombotic Microangiopathies
|
|
0.010 |
GeneticVariation
|
BEFREE |
Subsequent tests revealed elevated serum levels of soluble C5b-9, and genetic testing revealed compound heterozygous c.184G > A (Val62Ile) and c.1204T > C (Tyr402His) single-nucleotide polymorphisms in complement factor H.We encountered a case of complement-mediated TMA accompanied by DIC, which was successfully treated with eculizumab.
|
28178155 |
2017 |
|
Schizophrenia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Next, we performed a genotype-phenotype analysis to identify the relationship between <i>CFH</i> Y402H polymorphism and clinical features of schizophrenia.
|
28293111 |
2017 |
|
Lupus Nephritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
There was a significantly higher ratio of CC/CT genotypes of rs1061170 in lupus nephritis patients with class III than in the other two classes (class III vs. class IV vs. class V: 21.0% vs. 9.7% vs. 9.4%; P = .044).
|
28403670 |
2017 |
|
Disseminated Intravascular Coagulation
|
|
0.010 |
GeneticVariation
|
BEFREE |
Subsequent tests revealed elevated serum levels of soluble C5b-9, and genetic testing revealed compound heterozygous c.184G > A (Val62Ile) and c.1204T > C (Tyr402His) single-nucleotide polymorphisms in complement factor H.We encountered a case of complement-mediated TMA accompanied by DIC, which was successfully treated with eculizumab.
|
28178155 |
2017 |
|
Major Depressive Disorder
|
|
0.010 |
GeneticVariation
|
BEFREE |
CFH is likely to play an important role in the development of MDD. rs1061170 has an important effect on age at onset of MDD in Han Chinese and may therefore be related to early pathogenesis of MDD, although further study is needed.
|
26941266 |
2016 |
|
Chronic Fatigue Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
Of particular interest is association of CFS with two missense variants in genes of complement activation, rs4151667 (L9H) in CFB and rs1061170 (Y402H) in CFH.
|
26116897 |
2015 |
|
Obesity
|
|
0.010 |
GeneticVariation
|
BEFREE |
Moreover, in exploratory analyses, we identified a number of possible interactions including between V249I and rs2669845 and dietary intake of ω-3 fatty acids (P = .004 and P = .009, respectively) for AMD; between rs2669845 and obesity (P = .03) for neovascular AMD; between T280M and complement component 3 (C3) R102G for AMD (P = .03); between rs2669845 and Y402H in complement factor H for AMD (P = .04); and between rs2669845, rs2853707, and V249I and C3 R102G for neovascular AMD (P = .008; .04; and .002, respectively).
|
24287500 |
2014 |
|
Wet age-related macular degeneration
|
|
0.010 |
GeneticVariation
|
BEFREE |
The purpose of this study is to evaluate the effect of complement factor H (CFH) Y402H CC and TT polymorphisms on treatment response to intravitreal ranibizumab injection in patients with wet age-related macular degeneration (AMD).
|
24367156 |
2013 |
|
Uveitis, Posterior
|
|
0.010 |
GeneticVariation
|
BEFREE |
Carriage of the CFH Y402H polymorphism in both alleles is associated with an increased risk for posterior uveitis and panuveitis presentation.
|
23497844 |
2013 |
|
Multifocal choroiditis
|
|
0.010 |
GeneticVariation
|
BEFREE |
To determine whether the complement factor H (CFH) tyrosine 402 histidine (Y402H) variant, recently shown to be associated with age-related macular degeneration (AMD) and multifocal choroiditis, is associated with specific ocular sarcoidosis clinical phenotypes in black and white persons.
|
23497844 |
2013 |
|
Panuveitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Carriage of the CFH Y402H polymorphism in both alleles is associated with an increased risk for posterior uveitis and panuveitis presentation.
|
23497844 |
2013 |
|
Ocular sarcoidosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The Y402H polymorphism of CFH seems to be associated with ocular sarcoidosis in black and white persons.
|
23497844 |
2013 |
|
Dry age-related macular degeneration
|
|
0.010 |
GeneticVariation
|
BEFREE |
Relationship between systemic cytokines and complement factor H Y402H polymorphism in patients with dry age-related macular degeneration.
|
24083687 |
2013 |
|
Malignant neoplasm of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
These findings suggest that CFH Y402H polymorphism may interact with cigarette smoking to effect the development of lung cancer in the Chinese population.
|
22197220 |
2012 |
|
Primary malignant neoplasm of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
These findings suggest that CFH Y402H polymorphism may interact with cigarette smoking to effect the development of lung cancer in the Chinese population.
|
22197220 |
2012 |
|
Sudden sensorineural hearing loss
|
|
0.010 |
GeneticVariation
|
BEFREE |
We conclude that CFH Y402H polymorphism and SSNHL risk are significantly related, and that diabetic CFH Y402H minor allele carriers may be susceptible to SSNHL.
|
22426290 |
2012 |
|
Membranoproliferative Glomerulonephritis, Type II
|
|
0.010 |
GeneticVariation
|
BEFREE |
The complement factor H Y402H variant was significantly increased in dense deposit disease.
|
22456601 |
2012 |
|
Glomerulonephritis, Membranoproliferative
|
|
0.010 |
GeneticVariation
|
BEFREE |
We report a 15-year-old boy diagnosed with MPGN II in whom genetic analyses of the CFH gene revealed that the patient was heterozygote for a polymorphism in exon 2 of the CFH (c.184G>A), heterozygote for a polymorphism in exon 9 of the CFH (c.1204C>T), and heterozygote for a polymorphism in exon 10 of the CFH (c.1419G>A).
|
22388616 |
2012 |
|
Carcinoma of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
These findings suggest that CFH Y402H polymorphism may interact with cigarette smoking to effect the development of lung cancer in the Chinese population.
|
22197220 |
2012 |
|
Lobular Neoplasia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Serum CFH autoantibodies and CFH Tyr402His were screened in the 241 LN patients.
|
22956549 |
2012 |
|
Impaired cognition
|
|
0.010 |
GeneticVariation
|
BEFREE |
The C3F and Y402H polymorphisms are strong independent predictors of moderate-to-severe neurocognitive dysfunction at 1 day following CEA.
|
20841369 |
2011 |
|
Rheumatoid Arthritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The CFH variants, I62V, Y402H, IVS1 and IVS10, known to associate strongly with AMD, did not show a significant association with the risk of developing RA despite a strong statistical power to detect such differences.
|
22059990 |
2011 |