rs1061622, TNFRSF1B

N. diseases: 33
Disease: Hyperandrogenism ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Hyperandrogenism
CUI: C0206081
Disease: Hyperandrogenism
0.020 GeneticVariation BEFREE The opposite behaviors in terms of clinical expressivity detected for CAPN-UCSNP44 and TNFR2-M196R rare variants suggest these variants to be sensitizing and protective factors respectively in adrenal hyperandrogenism. 19039234 2009
Hyperandrogenism
CUI: C0206081
Disease: Hyperandrogenism
0.020 GeneticVariation BEFREE In conclusion, the M196R (676 T-->G) variant in exon 6 of TNFRSF1B is associated with hyperandrogenism and PCOS, further suggesting a role for inflammatory cytokines in the pathogenesis of these disorders. 12161545 2002