|
Coronary heart disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
One of the lead single nucleotide polymorphisms, rs10757278, was mostly investigated in association with coronary artery disease but rarely with carotid atherosclerosis.
|
26941057 |
2016 |
|
Coronary heart disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
Common variants in the 9p21.3 locus have been reported to be associated with multiple cardiovascular phenotypes, including coronary artery disease and intracranial aneurysms (rs10757278 and rs1333040).
|
24777168 |
2014 |
|
Coronary heart disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
Recently independent studies reported an association between coronary heart disease and single-nucleotide polymorphisms (SNPs) located at chromosome 9p21 (rs10757278 and proxy SNPs).
|
24625579 |
2014 |
|
Coronary heart disease
|
|
0.800 |
GeneticVariation
|
GWASDB |
A genome-wide association study of a coronary artery disease risk variant.
|
23364394 |
2013 |
|
Coronary heart disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
A case-control study to investigate the association of the 9p21 single nucleotide polymorphisms (SNPs) rs10757274 and rs10757278 (known to be associated with coronary artery disease [CAD] risk) with peripheral arterial disease (PAD), in a Han Chinese population.
|
23569135 |
2013 |
|
Coronary heart disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
We also sought to examine whether this variant, in combination with a chromosome 9p21 CHD variant (rs10757278) and the Framingham risk score (FRS), could improve the prediction of events compared with the FRS alone.
|
21444365 |
2012 |
|
Coronary heart disease
|
|
0.800 |
GeneticVariation
|
GWASDB |
Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease.
|
22751097 |
2012 |
|
Coronary heart disease
|
|
0.800 |
GeneticVariation
|
GWASDB |
Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.
|
21347282 |
2011 |
|
Coronary heart disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
Nine loci were statistically associated with incident CHD events in white participants: 9p21 (rs10757278; P=4.7 × 10(-41)), 16q23.1 (rs2549513; P=0.0004), 6p24.1 (rs499818; P=0.0002), 2q36.3 (rs2943634; P=6.7 × 10(-6)), MTHFD1L (rs6922269, P=5.1 × 10(-10)), APOE (rs429358; P=2.7×10(-18)), ZNF627 (rs4804611; P=5.0 × 10(-8)), CXCL12 (rs501120; P=1.4 × 10(-6)) and LPL (rs268; P=2.7 × 10(-17)).
|
22042884 |
2011 |
|
Coronary heart disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
Significantly reduced expression of all INK4/ARF transcripts (p15(INK4b), p16(INK4a), ARF and ANRIL) was found in PBTL of individuals harboring a common SNP (rs10757278) associated with increased risk of coronary artery disease, stroke and aortic aneurysm.
|
19343170 |
2009 |
|
Coronary heart disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
The risk variant on chromosome 9, tagged by rs10757278, is associated with coronary heart disease in the Belgian population, but not with isolated CVD.
|
19319159 |
2009 |
|
Coronary heart disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
Conclusions The rs10757278 and rs2383207 variants are determinants for early-onset coronary artery disease.
|
18459066 |
2009 |
|
Coronary heart disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
Recent genome wide association (GWA) studies identified two Single Nucleotide Polymorphisms (SNP) (rs10757278 and rs10757274) in the region of the CDK2NA and CDK2NB genes to be consistently associated with the risks of coronary heart disease (CHD) and myocardial infarction (MI).
|
18925945 |
2008 |