|
Myocardial Infarction
|
|
0.900 |
GeneticVariation
|
BEFREE |
While we confirmed the association of rs10757278 with CDKN2B expression in MI patients, we failed to find an association between the investigated variants and MI or disease burden.
|
31386834 |
2019 |
|
Myocardial Infarction
|
|
0.900 |
GeneticVariation
|
BEFREE |
The aim of the study was to find whether patients carrying polymorphic allele of the rs10757278 polymorphism from 9p21 locus have changed risk of arrhythmia (atrial fibrillation, AF; sustained ventricular tachycardia or ventricular fibrillation, sVT/VF) during acute phase of myocardial infarction.
|
26615606 |
2016 |
|
Myocardial Infarction
|
|
0.900 |
GeneticVariation
|
BEFREE |
We found even more significant association between rs</span>10757278 polymorphism and MI in pooled population, p = 3.55 × 10-53, after excluding the study from the Pakistan population.
|
26006241 |
2015 |
|
Myocardial Infarction
|
|
0.900 |
GeneticVariation
|
BEFREE |
Genome-wide association studies have identified 2 single-nucleotide polymorphisms (SNPs) on chromosome arm 9p21, rs10757278, and rs2383207 that confer susceptibility to myocardial infarction.
|
23454037 |
2013 |
|
Myocardial Infarction
|
|
0.900 |
GeneticVariation
|
BEFREE |
We replicated the association between the rs10757278 SNP and myocardial infarction and binary (presence/absence) angiographic classifications of CAD.
|
20729229 |
2010 |
|
Myocardial Infarction
|
|
0.900 |
GeneticVariation
|
BEFREE |
Background Two single nucleotide polymorphisms (SNPs, rs10757278 and rs2383207) on chromosome 9p21 have been proved to be associated with myocardial infarction.
|
18459066 |
2009 |
|
Myocardial Infarction
|
|
0.900 |
GeneticVariation
|
BEFREE |
We related SNPs rs2383207 and rs10757278 to stroke and to myocardial infarction and coronary revascularizations (coronary events) using crude and multivariate adjusted Cox proportional hazards models.
|
19293724 |
2009 |
|
Myocardial Infarction
|
|
0.900 |
GeneticVariation
|
BEFREE |
A common variant at chromosome 9p21 (tagged by the rs1333049 or rs10757278 single-nucleotide polymorphism) is strongly associated with myocardial infarction and major arterial aneurysms.
|
20031606 |
2009 |
|
Myocardial Infarction
|
|
0.900 |
GeneticVariation
|
BEFREE |
This study presents the first analysis of these SNPs (rs10757274, rs2383206, rs2383207, and rs10757278) in a premature, familial CAD/MI population (GeneQuest).
|
18505420 |
2008 |
|
Myocardial Infarction
|
|
0.900 |
GeneticVariation
|
BEFREE |
Genome-wide single nucleotide polymorphism (SNP) association studies recently identified four SNPs (rs10757274, rs2383206, rs2383207, and rs10757278) on chromosome 9p21 that were associated with coronary artery disease (CAD) and myocardial infarction (MI) in Caucasian populations from northern Europe and North America.
|
18066490 |
2008 |
|
Myocardial Infarction
|
|
0.900 |
GeneticVariation
|
BEFREE |
Recent genome-wide association studies have identified 4 SNPs on chromosome 9p21 associated with CAD (rs10757274 and rs2383206) and myocardial infarction (MI: rs2383207 and rs10757278) in White populations in Northern Europe and North America.
|
18048766 |
2008 |
|
Myocardial Infarction
|
|
0.900 |
GeneticVariation
|
BEFREE |
Recent genome wide association (GWA) studies identified two Single Nucleotide Polymorphisms (SNP) (rs10757278 and rs10757274) in the region of the CDK2NA and CDK2NB genes to be consistently associated with the risks of coronary heart disease (CHD) and myocardial infarction (MI).
|
18925945 |
2008 |
|
Myocardial Infarction
|
|
0.900 |
GeneticVariation
|
GWASCAT |
A common variant on chromosome 9p21 affects the risk of myocardial infarction.
|
17478679 |
2007 |
|
Myocardial Infarction
|
|
0.900 |
GeneticVariation
|
GWASDB |
A common variant on chromosome 9p21 affects the risk of myocardial infarction.
|
17478679 |
2007 |
|
Coronary heart disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
One of the lead single nucleotide polymorphisms, rs10757278, was mostly investigated in association with coronary artery disease but rarely with carotid atherosclerosis.
|
26941057 |
2016 |
|
Coronary heart disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
Common variants in the 9p21.3 locus have been reported to be associated with multiple cardiovascular phenotypes, including coronary artery disease and intracranial aneurysms (rs10757278 and rs1333040).
|
24777168 |
2014 |
|
Coronary heart disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
Recently independent studies reported an association between coronary heart disease and single-nucleotide polymorphisms (SNPs) located at chromosome 9p21 (rs10757278 and proxy SNPs).
|
24625579 |
2014 |
|
Coronary heart disease
|
|
0.800 |
GeneticVariation
|
GWASDB |
A genome-wide association study of a coronary artery disease risk variant.
|
23364394 |
2013 |
|
Coronary heart disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
A case-control study to investigate the association of the 9p21 single nucleotide polymorphisms (SNPs) rs10757274 and rs10757278 (known to be associated with coronary artery disease [CAD] risk) with peripheral arterial disease (PAD), in a Han Chinese population.
|
23569135 |
2013 |
|
Coronary heart disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
We also sought to examine whether this variant, in combination with a chromosome 9p21 CHD variant (rs10757278) and the Framingham risk score (FRS), could improve the prediction of events compared with the FRS alone.
|
21444365 |
2012 |
|
Coronary heart disease
|
|
0.800 |
GeneticVariation
|
GWASDB |
Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease.
|
22751097 |
2012 |
|
Coronary heart disease
|
|
0.800 |
GeneticVariation
|
GWASDB |
Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.
|
21347282 |
2011 |
|
Coronary heart disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
Nine loci were statistically associated with incident CHD events in white participants: 9p21 (rs10757278; P=4.7 × 10(-41)), 16q23.1 (rs2549513; P=0.0004), 6p24.1 (rs499818; P=0.0002), 2q36.3 (rs2943634; P=6.7 × 10(-6)), MTHFD1L (rs6922269, P=5.1 × 10(-10)), APOE (rs429358; P=2.7×10(-18)), ZNF627 (rs4804611; P=5.0 × 10(-8)), CXCL12 (rs501120; P=1.4 × 10(-6)) and LPL (rs268; P=2.7 × 10(-17)).
|
22042884 |
2011 |
|
Coronary heart disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
Significantly reduced expression of all INK4/ARF transcripts (p15(INK4b), p16(INK4a), ARF and ANRIL) was found in PBTL of individuals harboring a common SNP (rs10757278) associated with increased risk of coronary artery disease, stroke and aortic aneurysm.
|
19343170 |
2009 |
|
Coronary heart disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
The risk variant on chromosome 9, tagged by rs10757278, is associated with coronary heart disease in the Belgian population, but not with isolated CVD.
|
19319159 |
2009 |