|
Childhood Acute Lymphoblastic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the studied Egyptian population, it can be concluded that the C allele, CC, and CT genotypes of <i>ARID5B</i> rs10821936 and the CA haplotype may be a susceptibility risk factor for pediatric and adult ALL.
|
31424309 |
2019 |
|
Childhood Acute Lymphoblastic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Similar results were observed when restricting our analyses to those with the B-ALL subtype: ARID5B rs10821936 RR = 2.22, 95% CI = 1.63-3.02, p = 9.63×10-8 and ARID5B rs7089424 RR = 2.13, 95% CI = 1.57-2.88, p = 2.81×10-7.
|
28817678 |
2017 |
|
Childhood Acute Lymphoblastic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Associations between ALL and rs10821936 and rs7089424 ARID5B SNPs were found (OR = 1.9, 95% CI (1.5-2.4) and OR = 2.0, 95% CI (1.6-2.5), respectively).
|
28476190 |
2016 |
|
Childhood Acute Lymphoblastic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our findings provide the rst evidence that SNPs ARID5B- rs10821936 and IKZF1-rs4132601 are associated with decreased B-lineage ALL susceptibility in Indian children.
|
27644650 |
2016 |
|
Childhood Acute Lymphoblastic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The SNPs (IKZF1 rs11978267, ARID5B rs10821936 and rs10994982, CEBPE rs2239633) were genotyped in 265 cases [169 acute lymphoblastic leukemia (ALL) and 96 acute myeloid leukaemia (AML)] and 505 controls by Taqman allelic discrimination assay.
|
24564228 |
2014 |
|
Childhood Acute Lymphoblastic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
We found that rs10821936 polymorphism in ARID5B gene was associated with increased risk for ALL (P < 0.0001; OR = 1.27; 95%CI, 1.17-1.37).
|
23975371 |
2014 |
|
Childhood Acute Lymphoblastic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
For ARID5B (rs10821936), homozygosity for the variant allele increased risk for the ALL/MLL- subgroup only (OR = 7.2, 95% CI = 2.5-20.6).
|
22422485 |
2013 |
|
Childhood Acute Lymphoblastic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, ARID5B rs10821936 could serve as a potential biomarker for assessing the risk of childhood ALL in Chinese children.
|
23608171 |
2013 |
|
Childhood Acute Lymphoblastic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Among 49 ARID5B SNPs interrogated, 10 were significantly associated with ALL susceptibility in both whites and Hispanics (P < .05), with risk alleles consistently more frequent in Hispanics than in whites. rs10821936 exhibited the most significant association in both races (P = 8.4 × 10(-20) in whites; P = 1 × 10(-6) in Hispanics), and genotype at this SNP was highly correlated with local Native American genetic ancestry (P = 1.8 × 10(-8)).
|
22291082 |
2012 |
|
Childhood Acute Lymphoblastic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
In an attempt to replicate the findings of 2 recent genome-wide association studies in a French-Canadian cohort, we confirmed the association of 5 SNPs [rs7073837 (P=4.2 x 10(-4)), rs10994982 (P=3.8 x 10(-4)), rs10740055 (P=1.6 x 10(-5)), rs10821936 (P=1.7 x 10(-7)) and rs7089424 (P=3.6 x 10(-7))] in the ARID5B gene with childhood acute lymphoblastic leukemia.
|
20460642 |
2010 |
|
Childhood Acute Lymphoblastic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Two SNPs in ARID5B not only differed between ALL and non-ALL groups (rs10821936, P = 1.4 x 10(-15), odds ratio (OR) = 1.91; rs10994982, P = 5.7 x 10(-9), OR = 1.62) but also distinguished B-hyperdiploid ALL from other subtypes (rs10821936, P = 1.62 x 10(-5), OR = 2.17; rs10994982, P = 0.003, OR 1.72).
|
19684603 |
2009 |