Gestational Diabetes
|
|
0.100 |
GeneticVariation
|
BEFREE |
We also found that the risk alleles of rs2383208 (b = -0.085, p = 0.003), rs4402960 (b = -0.057, p = 0.046) and rs10830963 (b = -0.096, p = 0.001) were associated with HOMA-B, while rs7754840 was associated with decrease in insulin AUC during a 100 g OGTT given at the time of GDM diagnosis (b = -0.080, p = 0.007).
|
22096510 |
2011 |
Gestational Diabetes
|
|
0.100 |
GeneticVariation
|
BEFREE |
Further conditional analyses results suggested that rs10830963 might be more likely functional in case/control analysis, although not clear in GDM-related phenotype analyses.
|
21658282 |
2011 |
Gestational Diabetes
|
|
0.100 |
GeneticVariation
|
BEFREE |
These polymorphisms were in or near the following genes: TCF7L2 (rs7903146), MTNR1B (rs10830963), IGF2BP2 (rs4402960), KCNJ11 (rs5219), CDKAL1 (rs7754840), KCNQ1 (rs2237892 and rs2237895) and GCK (rs4607517); while no association was found for PPARG with GDM risk.
|
23029294 |
2012 |
Gestational Diabetes
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our study confirms the association of GDM with the rs10830963 (C/G) variant in a sample of the Greek population.
|
22450346 |
2012 |
Gestational Diabetes
|
|
0.100 |
GeneticVariation
|
BEFREE |
The minor alleles of rs7903146 (TCF7L2), rs12255372 (TCF7L2), rs1799884 (-30G/A, GCK), rs5219 (E23K, KCNJ11), rs7754840 (CDKAL1), rs4402960 (IGF2BP2), rs10830963 (MTNR1B), rs1387153 (MTNR1B) and rs1801278 (Gly972Arg, IRS1) were significantly associated with a higher risk of GDM.
|
23690305 |
2013 |
Gestational Diabetes
|
|
0.100 |
GeneticVariation
|
BEFREE |
Risk variants rs10830963 and rs1387153 of MTNR1B were significantly associated with GDM (odds ratio (OR)=1.62 (95% CI 1.34-1.96), P=4.5 × 10⁻⁷ and 1.38 (1.14-1.66), P=7.6 × 10⁻⁴ respectively).
|
23761423 |
2013 |
Gestational Diabetes
|
|
0.100 |
GeneticVariation
|
BEFREE |
The genetic polymorphisms rs2119882 in MTNR1A and rs10830963 in MTNR1B are associated with an increased risk of developing GDM and insulin resistance in Han Chinese women.
|
24157813 |
2013 |
Gestational Diabetes
|
|
0.100 |
GeneticVariation
|
BEFREE |
rs10830963 was associated cross-sectionally with fasting glucose (p = 0.0069), acute insulin response (AIR; p = 0.0013), disposition index (p = 0.00078), glucose effectiveness (p = 0.018) and gestational diabetes mellitus (OR 1.48; p = 0.012), but not with OGTT 30 min Δinsulin (the difference between the 30 min and fasting plasma insulin concentration) or 30 min insulin-based disposition index. rs10830963 was also associated with rate of change in fasting glucose (p = 0.043), OGTT 30 min Δinsulin (p = 0.01) and AIR (p = 0.037).
|
24728128 |
2014 |
Gestational Diabetes
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results showed a significant association between the three genetic variants and GDM risk, rs10830963 with a P-value less than 0.0001, rs1387153 with a P-value of 0.0002, and rs1801278 with a P-value of 0.001.
|
25146448 |
2014 |
Gestational Diabetes
|
|
0.100 |
GeneticVariation
|
BEFREE |
Overall GDM was associated with rs10830963(MTNR1B), rs7903146(TCF7L2), and rs1801278(IRS1), but only rs7903146(TCF7L2) and rs1801282(PPARG) were significant in Asian populations.
|
27468700 |
2016 |
Gestational Diabetes
|
|
0.100 |
GeneticVariation
|
BEFREE |
The further meta-analysis included other five studies showed that the frequency of MTNR1B rs10830963 G allele and rs1387153 T allele are higher in GDM patients.
|
26563312 |
2016 |
Gestational Diabetes
|
|
0.100 |
GeneticVariation
|
BEFREE |
A significant interaction was observed between the rs</span>10830963 genotypes and the lifestyle intervention on age-adjusted occurrence of gestational diabetes (p = 0.038).
|
27209463 |
2016 |
Gestational Diabetes
|
|
0.100 |
GeneticVariation
|
BEFREE |
These findings indicate that the association of sausage consumption with GDM risk can be determined based on the number of risk alleles of rs10830963 in <i>MTNR1B</i> and rs1799884 in <i>GCK</i>.
|
29340108 |
2017 |
Gestational Diabetes
|
|
0.100 |
GeneticVariation
|
BEFREE |
We confirmed the robust association of MTNR1B rs10830963/G variant with GDM binary and glycemic traits in this Caucasian case-control study.
|
28072873 |
2017 |
Gestational Diabetes
|
|
0.100 |
GeneticVariation
|
BEFREE |
With regard to the MTNR1B rs10830963 polymorphism, we observed a statistically significant prevalence of GG and CG genotypes and the G allele among pregnant women with GDM (GG + CG vs CC, OR 1.50, 95% CI 1.02-2.22, p = 0.04; G vs C, OR 1.43, 95% CI 1.07-1.90, p = 0.016).
|
28084098 |
2017 |
Gestational Diabetes
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our meta-analysis indicated that the rs10830963 polymorphism might serve as a risk factor of GDM in the Chinese population.
|
28879649 |
2017 |
Gestational Diabetes
|
|
0.100 |
GeneticVariation
|
BEFREE |
The established circadian rhythm-associated MTNR1B genetic variant (rs10830963) was genotyped in 1025 Chinese women with a history of GDM.
|
29590381 |
2018 |
Gestational Diabetes
|
|
0.100 |
GeneticVariation
|
BEFREE |
Carrying the <i>MTNR1B</i> rs10830963/<i>G</i> risk allele-in interaction with pre-pregnancy BMI-is likely be considered as a candidate pharmacogenetic marker of antenatal insulin therapy initiation and should be further assessed in precision medicine trials in GDM.
|
30477160 |
2018 |
Gestational Diabetes
|
|
0.100 |
GeneticVariation
|
BEFREE |
In addition, we confirmed three variants, rs10830963 (MTNR1B), rs1387153 (MTNR1B) and rs4506565 (TCF7L2), that had previously been significantly associated with GDM risk.
|
29947923 |
2018 |
Gestational Diabetes
|
|
0.100 |
GeneticVariation
|
BEFREE |
Furthermore, rs10830963 may tag a molecular mechanism leading to insulin resistance in Han Chinese women with GDM.
|
29656698 |
2019 |
Gestational Diabetes
|
|
0.100 |
GeneticVariation
|
BEFREE |
FPRP and TSA analyses confirmed findings support that the rs10830963 G allele increases the risk of GDM, and further functional experimental studies are warranted to explore and clarify the potential mechanism.
|
31808503 |
2019 |
Gestational Diabetes
|
|
0.100 |
GeneticVariation
|
BEFREE |
The findings of this study suggest that rs10830963 and rs7936247 may be markers for susceptibility to GDM in a Chinese population.
|
30912250 |
2019 |
Gestational Diabetes
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our findings indicated that <i>MTNR1B</i> rs1387153, rs4753426, and rs10830963 variants might serve as genetic biomarkers of GDM.
|
30991439 |
2019 |