rs10830963, MTNR1B

N. diseases: 27
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Gestational Diabetes
CUI: C0085207
Disease: Gestational Diabetes
0.100 GeneticVariation BEFREE Furthermore, rs10830963 may tag a molecular mechanism leading to insulin resistance in Han Chinese women with GDM. 29656698 2019
Gestational Diabetes
CUI: C0085207
Disease: Gestational Diabetes
0.100 GeneticVariation BEFREE FPRP and TSA analyses confirmed findings support that the rs10830963 G allele increases the risk of GDM, and further functional experimental studies are warranted to explore and clarify the potential mechanism. 31808503 2019
Gestational Diabetes
CUI: C0085207
Disease: Gestational Diabetes
0.100 GeneticVariation BEFREE The findings of this study suggest that rs10830963 and rs7936247 may be markers for susceptibility to GDM in a Chinese population. 30912250 2019
Gestational Diabetes
CUI: C0085207
Disease: Gestational Diabetes
0.100 GeneticVariation BEFREE Our findings indicated that <i>MTNR1B</i> rs1387153, rs4753426, and rs10830963 variants might serve as genetic biomarkers of GDM. 30991439 2019
Gestational Diabetes
CUI: C0085207
Disease: Gestational Diabetes
0.100 GeneticVariation BEFREE The established circadian rhythm-associated MTNR1B genetic variant (rs10830963) was genotyped in 1025 Chinese women with a history of GDM. 29590381 2018
Gestational Diabetes
CUI: C0085207
Disease: Gestational Diabetes
0.100 GeneticVariation BEFREE Carrying the <i>MTNR1B</i> rs10830963/<i>G</i> risk allele-in interaction with pre-pregnancy BMI-is likely be considered as a candidate pharmacogenetic marker of antenatal insulin therapy initiation and should be further assessed in precision medicine trials in GDM. 30477160 2018
Gestational Diabetes
CUI: C0085207
Disease: Gestational Diabetes
0.100 GeneticVariation BEFREE In addition, we confirmed three variants, rs10830963 (MTNR1B), rs1387153 (MTNR1B) and rs4506565 (TCF7L2), that had previously been significantly associated with GDM risk. 29947923 2018
Gestational Diabetes
CUI: C0085207
Disease: Gestational Diabetes
0.100 GeneticVariation BEFREE These findings indicate that the association of sausage consumption with GDM risk can be determined based on the number of risk alleles of rs10830963 in <i>MTNR1B</i> and rs1799884 in <i>GCK</i>. 29340108 2017
Gestational Diabetes
CUI: C0085207
Disease: Gestational Diabetes
0.100 GeneticVariation BEFREE We confirmed the robust association of MTNR1B rs10830963/G variant with GDM binary and glycemic traits in this Caucasian case-control study. 28072873 2017
Gestational Diabetes
CUI: C0085207
Disease: Gestational Diabetes
0.100 GeneticVariation BEFREE With regard to the MTNR1B rs10830963 polymorphism, we observed a statistically significant prevalence of GG and CG genotypes and the G allele among pregnant women with GDM (GG + CG vs CC, OR 1.50, 95% CI 1.02-2.22, p = 0.04; G vs C, OR 1.43, 95% CI 1.07-1.90, p = 0.016). 28084098 2017
Gestational Diabetes
CUI: C0085207
Disease: Gestational Diabetes
0.100 GeneticVariation BEFREE Our meta-analysis indicated that the rs10830963 polymorphism might serve as a risk factor of GDM in the Chinese population. 28879649 2017
Gestational Diabetes
CUI: C0085207
Disease: Gestational Diabetes
0.100 GeneticVariation BEFREE Overall GDM was associated with rs10830963(MTNR1B), rs7903146(TCF7L2), and rs1801278(IRS1), but only rs7903146(TCF7L2) and rs1801282(PPARG) were significant in Asian populations. 27468700 2016
Gestational Diabetes
CUI: C0085207
Disease: Gestational Diabetes
0.100 GeneticVariation BEFREE The further meta-analysis included other five studies showed that the frequency of MTNR1B rs10830963 G allele and rs1387153 T allele are higher in GDM patients. 26563312 2016
Gestational Diabetes
CUI: C0085207
Disease: Gestational Diabetes
0.100 GeneticVariation BEFREE A significant interaction was observed between the rs</span>10830963 genotypes and the lifestyle intervention on age-adjusted occurrence of gestational diabetes (p = 0.038). 27209463 2016
Gestational Diabetes
CUI: C0085207
Disease: Gestational Diabetes
0.100 GeneticVariation BEFREE rs10830963 was associated cross-sectionally with fasting glucose (p = 0.0069), acute insulin response (AIR; p = 0.0013), disposition index (p = 0.00078), glucose effectiveness (p = 0.018) and gestational diabetes mellitus (OR 1.48; p = 0.012), but not with OGTT 30 min Δinsulin (the difference between the 30 min and fasting plasma insulin concentration) or 30 min insulin-based disposition index. rs10830963 was also associated with rate of change in fasting glucose (p = 0.043), OGTT 30 min Δinsulin (p = 0.01) and AIR (p = 0.037). 24728128 2014
Gestational Diabetes
CUI: C0085207
Disease: Gestational Diabetes
0.100 GeneticVariation BEFREE Our results showed a significant association between the three genetic variants and GDM risk, rs10830963 with a P-value less than 0.0001, rs1387153 with a P-value of 0.0002, and rs1801278 with a P-value of 0.001. 25146448 2014
Gestational Diabetes
CUI: C0085207
Disease: Gestational Diabetes
0.100 GeneticVariation BEFREE The minor alleles of rs7903146 (TCF7L2), rs12255372 (TCF7L2), rs1799884 (-30G/A, GCK), rs5219 (E23K, KCNJ11), rs7754840 (CDKAL1), rs4402960 (IGF2BP2), rs10830963 (MTNR1B), rs1387153 (MTNR1B) and rs1801278 (Gly972Arg, IRS1) were significantly associated with a higher risk of GDM. 23690305 2013
Gestational Diabetes
CUI: C0085207
Disease: Gestational Diabetes
0.100 GeneticVariation BEFREE Risk variants rs10830963 and rs1387153 of MTNR1B were significantly associated with GDM (odds ratio (OR)=1.62 (95% CI 1.34-1.96), P=4.5 × 10⁻⁷ and 1.38 (1.14-1.66), P=7.6 × 10⁻⁴ respectively). 23761423 2013
Gestational Diabetes
CUI: C0085207
Disease: Gestational Diabetes
0.100 GeneticVariation BEFREE The genetic polymorphisms rs2119882 in MTNR1A and rs10830963 in MTNR1B are associated with an increased risk of developing GDM and insulin resistance in Han Chinese women. 24157813 2013
Gestational Diabetes
CUI: C0085207
Disease: Gestational Diabetes
0.100 GeneticVariation BEFREE These polymorphisms were in or near the following genes: TCF7L2 (rs7903146), MTNR1B (rs10830963), IGF2BP2 (rs4402960), KCNJ11 (rs5219), CDKAL1 (rs7754840), KCNQ1 (rs2237892 and rs2237895) and GCK (rs4607517); while no association was found for PPARG with GDM risk. 23029294 2012
Gestational Diabetes
CUI: C0085207
Disease: Gestational Diabetes
0.100 GeneticVariation BEFREE Our study confirms the association of GDM with the rs10830963 (C/G) variant in a sample of the Greek population. 22450346 2012
Gestational Diabetes
CUI: C0085207
Disease: Gestational Diabetes
0.100 GeneticVariation BEFREE We also found that the risk alleles of rs2383208 (b = -0.085, p = 0.003), rs4402960 (b = -0.057, p = 0.046) and rs10830963 (b = -0.096, p = 0.001) were associated with HOMA-B, while rs7754840 was associated with decrease in insulin AUC during a 100 g OGTT given at the time of GDM diagnosis (b = -0.080, p = 0.007). 22096510 2011
Gestational Diabetes
CUI: C0085207
Disease: Gestational Diabetes
0.100 GeneticVariation BEFREE Further conditional analyses results suggested that rs10830963 might be more likely functional in case/control analysis, although not clear in GDM-related phenotype analyses. 21658282 2011