Using a significance threshold of FDR < 0.1, association was detected for rs10941112 (p = 2.1 × 10<sup>-5</sup> ; q-value = 0.073) in AMACR, a gene involved in fatty acid metabolism and previously implicated in schizophrenia, with significant cis effects on gene expression (p = 5.5 × 10<sup>-4</sup> ), including brain tissue data from the Genotype-Tissue Expression project (minimum p = 6.0 × 10<sup>-5</sup> ).
The G-C-G haplotype of rs2278008-rs2287939-rs10941112 revealed the most significant association with schizophrenia (P = 4.25 × 10-6, OR = 2.96; 95% CI: 1.85-4.76) in male subjects.