|
Coronary heart disease
|
|
0.800 |
GeneticVariation
|
GWASDB |
A genome-wide association study of a coronary artery disease risk variant.
|
23364394 |
2013 |
|
High density lipoprotein measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels.
|
28334899 |
2017 |
|
Major Depressive Disorder
|
|
0.700 |
GeneticVariation
|
GWASDB |
Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies.
|
23377640 |
2013 |
|
Hypertensive disease
|
|
0.710 |
GeneticVariation
|
BEFREE |
Five gene variants, rs11066280 (C12orf51), rs12229654 and rs3782889 (MYL2), rs2072134 (OAS3), rs2093395 (TREML2), and rs17249754 (ATP2B1), were found to be associated with hypertension mostly in men (P = 4.76 × 10(-14) to 4.46 × 10(-7) in the joint analysis); three SNPs (rs11066280, rs12229654, and rs3782889) remained significant after Bonferroni correction in an independent population.
|
24142389 |
2014 |
|
Triglycerides measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genetic Susceptibility to Lipid Levels and Lipid Change Over Time and Risk of Incident Hyperlipidemia in Chinese Populations.
|
26582766 |
2016 |
|
Esophageal Neoplasms
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations.
|
21642993 |
2011 |
|
Malignant neoplasm of esophagus
|
|
0.700 |
GeneticVariation
|
GWASDB |
Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations.
|
21642993 |
2011 |
|
Hypertensive disease
|
|
0.710 |
GeneticVariation
|
GWASCAT |
Genome-wide association study in Chinese identifies novel loci for blood pressure and hypertension.
|
25249183 |
2015 |
|
Systolic Pressure
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide association study in Chinese identifies novel loci for blood pressure and hypertension.
|
25249183 |
2015 |
|
Diastolic blood pressure
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide association study in Chinese identifies novel loci for blood pressure and hypertension.
|
25249183 |
2015 |
|
Coronary heart disease
|
|
0.800 |
GeneticVariation
|
GWASDB |
Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease.
|
22751097 |
2012 |
|
Coronary heart disease
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease.
|
22751097 |
2012 |
|
Coronary heart disease
|
|
0.800 |
GeneticVariation
|
GWASDB |
Genome-wide association study of coronary artery disease in the Japanese.
|
21971053 |
2012 |
|
Alcohol consumption
|
|
0.700 |
GeneticVariation
|
GWASDB |
Genome-wide testing of putative functional exonic variants in relationship with breast and prostate cancer risk in a multiethnic population.
|
23555315 |
2013 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, even in never-drinkers, minor allele homozygote strongly influenced T2D risk reduction (rs2074356 for AA: HR = 0.35, 95% CI = 0.14-0.90, and p-trend = 0.0035 in men and HR = 0.34, 95% CI = 0.13-0.93, and p-trend = 0.2348 in women; rs11066280 for AA: HR = 0.36, 95% CI = 0.16-0.82, and p-trend = 0.0014 in men and HR = 0.39, 95% CI = 0.16-0.95, and p-trend = 0.3790 in women), while alcohol consumption did not influence the risk of T2D within each genotype. rs2074356 and rs11066280 in or near C12orf51, which is related to alcohol drinking behavior, may longitudinally decrease the risk of T2D, but not through regulation of alcohol consumption.
|
26891264 |
2016 |
|
Neoplasm Metastasis
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, in the stratification analysis of histology, we found that the rs11066280 TA/AA genotypes were associated with a poor survival of intestinal-type gastric cancer (log-rank P=0.041, hazard ratio [HR]=1.40, 95% confidence interval [CI]=1.02-1.93), Moreover, this hazardous effect was more prominent among patients with tumor size>5cm, no distant metastasis, chemotherapy and drinking.
|
25661349 |
2015 |
|
Uric acid measurement (procedure)
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Identification of CDC42BPG as a novel susceptibility locus for hyperuricemia in a Japanese population.
|
29124443 |
2018 |
|
Metabolic Syndrome X
|
|
0.700 |
GeneticVariation
|
GWASCAT |
In the discovery phase, SNPs from chromosome 12, including rs11066280, rs2074356, and rs12229654, were associated with MetS (p < 5 × 10(-6)), and rs11066280 satisfied the Bonferroni-corrected cutoff (unadjusted p < 1.38 × 10(-7), Bonferroni-adjusted p < 0.05).
|
25705158 |
2014 |
|
Serum Alanine Aminotransferase Measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits.
|
21909109 |
2011 |
|
Serum albumin measurement
|
|
0.700 |
GeneticVariation
|
GWASDB |
Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits.
|
21909109 |
2011 |
|
Alanine aminotransferase measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits.
|
21909109 |
2011 |
|
Blood Pressure
|
|
0.700 |
GeneticVariation
|
GWASDB |
Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians.
|
21572416 |
2011 |
|
Systolic Pressure
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians.
|
21572416 |
2011 |
|
Diastolic blood pressure
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians.
|
21572416 |
2011 |
|
Squamous cell carcinoma of esophagus
|
|
0.010 |
GeneticVariation
|
BEFREE |
Recent genome-wide association study (GWAS) on esophageal squamous-cell carcinoma (ESCC) among Chinese population has identified two novel single nucleotide polymorphisms (SNPs) rs11066280 and rs2074356 on C12orf51 gene.
|
25661349 |
2015 |