|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
An uncommon coding variant (rs11209026, c.1142G>A, p.Arg381Gln) confers strong protection against Crohn's disease, and additional noncoding IL23R variants are independently associated.
|
17068223 |
2006 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
GWASDB |
Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4.
|
17447842 |
2007 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4.
|
17447842 |
2007 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
A highly significant association with CD was observed, with the strongest signal at coding variant Arg381Gln (allele frequency, 2.5% in CD vs 6.2% in controls [P = 1.1 x 10(-12)]; odds ratio, 0.38; 95% confidence interval, 0.29-0.50).
|
17484863 |
2007 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Recently an association was shown between the single nucleotide polymorphism (SNP), rs11209026, within the interleukin-23 receptor (IL23R) locus and Crohn's disease (CD) as a consequence of a genome-wide association study of this disease in adults.
|
17618837 |
2007 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
GWASDB |
Systematic association mapping identifies NELL1 as a novel IBD disease gene.
|
17684544 |
2007 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
IL23R is an IBD susceptibility gene, but has no epistatic interaction with CARD15 and SLC22A4/5. rs1004819 is the major IL23R variant associated with CD in the German population, while the p.Arg381Gln IL23R variant is a protective marker for CD and UC.
|
17786191 |
2007 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease loci.
|
17804789 |
2007 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
GWASDB |
Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease loci.
|
17804789 |
2007 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The p.Arg381Gln IL23R variant confers a protective effect against both CD and UC, but does not determine disease phenotype.
|
17877509 |
2007 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
IL23R R381Q and ATG16L1 T300A are strongly associated with Crohn's disease in a study of New Zealand Caucasians with inflammatory bowel disease.
|
17894849 |
2007 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
We also provide further evidence for association of rs11209026</span> with UC and a report of an additive effect between IL23R and CARD15 genotypes in CD.
|
17894849 |
2007 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Evaluation of the interleukin-23 receptor gene coding variant R381Q in pediatric and adult Crohn disease.
|
18030204 |
2007 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
One, an uncommon coding variant (rs11209026) in the gene encoding for the interleukin-23 receptor (IL23R), conferred strong protection against CD.
|
18047540 |
2008 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The rs11209026 SNP, which is the most strongly associated with Crohn's disease, was not associated with GD or GO in our data set.
|
18073300 |
2008 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Variants of CARD15 (3020insC and R702W) and IL23R (rs1004819, rs11209026, and rs1088967) were associated with CD.
|
18200510 |
2008 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Recent studies have shown that a nonsynonymous single-nucleotide polymorphism (SNP) (Arg381Gln; rs11209026) in the interleukin-23 receptor (IL-23R) gene on chromosome 1p31 is associated with Crohn's disease and psoriasis.
|
18383363 |
2008 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
These observations suggest that IL23R makes a substantial contribution to CD susceptibility, larger than that estimated from the population frequency of the R381Q variant.
|
18470928 |
2008 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
GWASDB |
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.
|
18587394 |
2008 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The rare allele of a non-synonymous interleukin 23 receptor (IL23R) single nucleotide polymorphism (SNP) rs11209026 (p.Arg381Gln) confers strong protection against Crohn disease (CD) and psoriasis.
|
18647855 |
2009 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
We confirm the association of CD with variants in the IL-23R and ATG16L1 genes and the more modest association of the IL-23R R381Q variant with UC.
|
19276991 |
2009 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The results suggest that IL23R R381Q confers protection against CD and that L310P confers protection against UC in females.
|
19294505 |
2010 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
An association of variants in the genes encoding the interleukin 23 receptor (IL23R, p.Arg381Gln, rs11209026), and the autophagy-related gene 16-like 1 (ATG16L1, p.Ala197Thr, rs2241880) with Crohn disease (CD) was identified by whole genome association studies, and subsequently confirmed by other works.
|
19590455 |
2009 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
An association of variants in the genes encoding the interleukin 23 receptor (IL23R, p.Arg381Gln, rs11209026), and the autophagy-related gene 16-like 1 (ATG16L1, p.Ala197Thr, rs2241880) with Crohn disease (CD) was identified by whole genome association studies, and subsequently confirmed by other works.
|
19590455 |
2009 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
One hundred and eighty unrelated IBD patients [57 Crohn's disease (CD) and 123 ulcerative colitis (UC)] and 186 healthy controls were genotyped for the following known genetic susceptibility variants: NOD2 - Arg702Trp (rs2066844), Gly908Arg (rs2066845) and Leu1007insC (rs2066847), as well as IL23R - Arg381Gln (rs11209026) and ATG16L1 - Thr300Ala (rs2241880).
|
20082483 |
2010 |