rs11209026, IL23R

N. diseases: 46
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Psoriasis
CUI: C0033860
Disease: Psoriasis
0.900 GeneticVariation BEFREE Case-control analysis revealed an association of IL12B rs3212227 and IL23R rs11209026 minor allele carrier status with reduced odds for psoriasis (OR = 0.66, 95%CI: 0.50-0.87, and OR = 0.41, 95%CI: 0.26-0.67, respectively), while HLA-C*06 allele carriers were more frequent in patients group (OR = 4.56, 95%CI: 3.41-6.10). 29454820 2018
Psoriasis
CUI: C0033860
Disease: Psoriasis
0.900 GeneticVariation BEFREE Although there was no significant association found between rs610604 (IL12B) and rs11209026 (IL23R) in this population, the interaction of these two genes showed a significant association with psoriasis (P-value: 0.025). 25406098 2015
Psoriasis
CUI: C0033860
Disease: Psoriasis
0.900 GeneticVariation GWASCAT Genome-wide comparative analysis of atopic dermatitis and psoriasis gives insight into opposing genetic mechanisms. 25574825 2015
Psoriasis
CUI: C0033860
Disease: Psoriasis
0.900 GeneticVariation BEFREE This study aims to assess whether the association between the non-susceptibility allelic variants of IL12B single-nucleotide polymorphism (SNPs) rs3212227 and rs6887695, IL23R SNPs rs11209026 and rs7530511, IL6 SNP rs1800795 and HLA-Cw6 could be correlated with decreased risk for psoriasis. 24140476 2014
Psoriasis
CUI: C0033860
Disease: Psoriasis
0.900 GeneticVariation BEFREE Our study showed significant associations between psoriasis and both IL12B gene SNPs, rs3212227 (odds ratio (OR) = 1.35, P = 4.94E-04) and rs6887695 (OR = 1.32, P = 2.00E-03), but no significant association between psoriasis and the IL23R SNP, rs11209026. 23955419 2013
Psoriasis
CUI: C0033860
Disease: Psoriasis
0.900 GeneticVariation BEFREE We and others have shown that the minor, nonconserved allele Gln381 of the Arg381Gln single-nucleotide polymorphism (rs11209026G>A) of the IL-23 receptor gene (IL23R) protects against psoriasis. 23563201 2013
Psoriasis
CUI: C0033860
Disease: Psoriasis
0.900 GeneticVariation BEFREE This meta-analysis showed that the IL-23 R (rs11209026 and rs7530511) polymorphisms are associated with psoriasis risk in Europeans and that the IL-12B (rs6887695 and rs3212227) polymorphisms are associated with susceptibility to psoriasis in Europeans. 23844553 2013
Psoriasis
CUI: C0033860
Disease: Psoriasis
0.900 GeneticVariation BEFREE We and others have shown that the minor, nonconserved allele Gln381 of the Arg381Gln single-nucleotide polymorphism (rs11209026G>A) of the IL-23 receptor gene (IL23R) protects against psoriasis. 23563201 2013
Psoriasis
CUI: C0033860
Disease: Psoriasis
0.900 GeneticVariation BEFREE For rs11209026, the odds ratios (ORs) of minor alleles for psoriasis and PsA were 0.616 [95 % confidence interval (CI) 0.563-0.674] and 0.630 (95 % CI 0.524-0.757), respectively. 22706445 2012
Psoriasis
CUI: C0033860
Disease: Psoriasis
0.900 GeneticVariation BEFREE Genome-wide association studies have shown that the IL23R R381Q gene variant protects against psoriasis, Crohn's disease and ankylosing spondylitis. 21364948 2011
Psoriasis
CUI: C0033860
Disease: Psoriasis
0.900 GeneticVariation GWASCAT A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1. 20953190 2010
Psoriasis
CUI: C0033860
Disease: Psoriasis
0.900 GeneticVariation GWASDB A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1. 20953190 2010
Psoriasis
CUI: C0033860
Disease: Psoriasis
0.900 GeneticVariation BEFREE The rare allele of a non-synonymous interleukin 23 receptor (IL23R) single nucleotide polymorphism (SNP) rs11209026 (p.Arg381Gln) confers strong protection against Crohn disease (CD) and psoriasis. 18647855 2009
Psoriasis
CUI: C0033860
Disease: Psoriasis
0.900 GeneticVariation BEFREE We replicated the previously reported association with interleukin 23 receptor and interleukin 12B (IL12B) polymorphisms in PS and PSA cohorts (IL23R: rs11209026, U.S. PS, P = 1.4x10(-4); U.K. PSA: P = 8.0x10(-4); IL12B:rs6887695, U.S. PS, P = 5x10(-5) and U.K. PSA, P = 1.3x10(-3)) and detected an independent association in the IL23R region with a SNP 4 kb upstream from IL12RB2 (P = 0.001). 18369459 2008
Psoriasis
CUI: C0033860
Disease: Psoriasis
0.900 GeneticVariation BEFREE A recent study reported that psoriasis was associated with the IL12B haplotype rs3212227 (3'-untranslated region)-rs6887695 (60 kb, 5') and the IL23R haplotype rs7530511 (L310P)-rs11209026 (Q381R). 18219280 2008
Psoriasis
CUI: C0033860
Disease: Psoriasis
0.900 GeneticVariation BEFREE Recent studies have shown that a nonsynonymous single-nucleotide polymorphism (SNP) (Arg381Gln; rs11209026) in the interleukin-23 receptor (IL-23R) gene on chromosome 1p31 is associated with Crohn's disease and psoriasis. 18383363 2008