rs112445441, KRAS

N. diseases: 17
Source: ALL
Disease Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Colorectal Cancer
CUI: C1527249
Disease: Colorectal Cancer
0.060 GeneticVariation BEFREE KRAS MASI is a significant event in colorectal cancer, specifically associated with G13D mutation, and featuring a heterogeneous spatial distribution, that may have a role to predict the response to EGFR inhibitors. 25609577 2015
Colorectal Cancer
CUI: C1527249
Disease: Colorectal Cancer
0.060 GeneticVariation BEFREE Higher metastatic efficiency of KRas G12V than KRas G13D in a colorectal cancer model. 25359494 2015
Colorectal Cancer
CUI: C1527249
Disease: Colorectal Cancer
0.060 GeneticVariation BEFREE Our finding that KRAS codon 13 mutations (in particular G13D) are associated with inferior survival in BRAF wild-type CRCs in Chinese patients was not reported thus far. 25367198 2015
Colorectal Cancer
CUI: C1527249
Disease: Colorectal Cancer
0.060 GeneticVariation BEFREE KRAS p.G13D mutations are associated with sensitivity to anti-EGFR antibody treatment in colorectal cancer cell lines. 23015072 2013
Colorectal Cancer
CUI: C1527249
Disease: Colorectal Cancer
0.060 GeneticVariation BEFREE In this analysis, use of cetuximab was associated with longer overall and progression-free survival among patients with chemotherapy-refractory colorectal cancer with p.G13D-mutated tumors than with other KRAS-mutated tumors. 20978259 2010
Colorectal Cancer
CUI: C1527249
Disease: Colorectal Cancer
0.060 GeneticVariation BEFREE Furthermore, HNPCC CRCs had more G13D mutations than MSS (P < 0.0001), MSI-H (P = 0.02) or MSI-H tumours with hMLH1 hypermethylation (P = 0.03). 15294875 2005