|
Nasopharyngeal carcinoma
|
|
0.700 |
GeneticVariation
|
GWASDB |
A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci.
|
20512145 |
2010 |
|
Malignant neoplasm of breast
|
|
0.770 |
GeneticVariation
|
GWASDB |
A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1).
|
19330030 |
2009 |
|
Breast Carcinoma
|
|
0.770 |
GeneticVariation
|
GWASCAT |
A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1).
|
19330030 |
2009 |
|
Neoplasms
|
|
0.050 |
GeneticVariation
|
BEFREE |
A pericentromeric SNP on chromosome 1p11.2 (rs11249433; P = 6.74 x 10(-10) adjusted genotype test, 2 degrees of freedom) resides in a large linkage disequilibrium block neighboring NOTCH2 and FCGR1B; this signal was stronger for estrogen-receptor-positive tumors.
|
19330030 |
2009 |
|
Malignant Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
A recent genome-wide association study (GWAS) has identified a single nucleotide polymorphism (SNP) rs11249433 in the 1p11.2 region as a novel genetic risk factor for breast cancer, and this association was stronger in patients with estrogen receptor (ER)+ versus ER- cancer.
|
20482849 |
2010 |
|
Primary malignant neoplasm
|
|
0.020 |
GeneticVariation
|
BEFREE |
A recent genome-wide association study (GWAS) has identified a single nucleotide polymorphism (SNP) rs11249433 in the 1p11.2 region as a novel genetic risk factor for breast cancer, and this association was stronger in patients with estrogen receptor (ER)+ versus ER- cancer.
|
20482849 |
2010 |
|
Invasive Ductal Breast Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
A total of 100 invasive ductal carcinoma (IDC) and 50 ductal carcinoma in situ (DCIS) patients and 100 usual ductal hyperplasia (UDH) controls were genotyped for the following Notch receptor single nucleotide polymorphisms (SNPs) using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry: Notch1, rs3124591; Notch2, rs11249433; Notch3, rs3815188, and rs1043994; and Notch4, rs367398, and rs520692.
|
25120811 |
2014 |
|
Noninfiltrating Intraductal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
A total of 100 invasive ductal carcinoma (IDC) and 50 ductal carcinoma in situ (DCIS) patients and 100 usual ductal hyperplasia (UDH) controls were genotyped for the following Notch receptor single nucleotide polymorphisms (SNPs) using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry: Notch1, rs3124591; Notch2, rs11249433; Notch3, rs3815188, and rs1043994; and Notch4, rs367398, and rs520692.
|
25120811 |
2014 |
|
Breast Carcinoma
|
|
0.770 |
GeneticVariation
|
GWASCAT |
Association analysis identifies 65 new breast cancer risk loci.
|
29059683 |
2017 |
|
Breast Carcinoma
|
|
0.770 |
GeneticVariation
|
BEFREE |
Further studies are needed to investigate possible mechanisms of regulation of NOTCH2 expression by rs11249433 and the role of NOTCH2 splicing forms in breast cancer</span> development.
|
20482849 |
2010 |
|
Malignant neoplasm of breast
|
|
0.770 |
GeneticVariation
|
BEFREE |
Further studies are needed to investigate possible mechanisms of regulation of NOTCH2 expression by rs11249433 and the role of NOTCH2 splicing forms in breast cancer</span> development.
|
20482849 |
2010 |
|
Neoplasms
|
|
0.050 |
GeneticVariation
|
BEFREE |
Further, among carriers of rs11249433, the highest risk was seen for E-cadherin low tumors that were ER-positive and of lobular histology.
|
24292867 |
2014 |
|
Breast Carcinoma
|
|
0.770 |
GeneticVariation
|
GWASCAT |
Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer.
|
25751625 |
2015 |
|
Breast Carcinoma
|
|
0.770 |
GeneticVariation
|
BEFREE |
However, no significant association was observed between rs11249433 and breast cancer risk in this Chinese population (dominant genetic model in combined samples: OR = 1.20, 95% CI = 0.92-1.57).
|
21738711 |
2011 |
|
Malignant neoplasm of breast
|
|
0.770 |
GeneticVariation
|
BEFREE |
However, no significant association was observed between rs11249433 and breast cancer risk in this Chinese population (dominant genetic model in combined samples: OR = 1.20, 95% CI = 0.92-1.57).
|
21738711 |
2011 |
|
Neoplasms
|
|
0.050 |
GeneticVariation
|
BEFREE |
In addition, our data indicate that 1p11-rs11249433 polymorphism is involved in BC susceptibility and confer its effect primarily in estrogen receptor-positive and progesterone receptor-positive tumors.
|
23977306 |
2013 |
|
Neoplasms
|
|
0.050 |
GeneticVariation
|
BEFREE |
In addition, we found that rs11249433 polymorphism on 1p11 confer risk, exclusively for ER-positive tumors with per-allele OR of 1.13 (95% CI: 1.08-1.18; P <10(-5)) compared to ER-negative tumors of 1.01 (95% CI: 0.98-1.04; P=0.49).
|
23977314 |
2013 |
|
Malignant neoplasm of breast
|
|
0.770 |
GeneticVariation
|
BEFREE |
In conclusion, this meta-analysis demonstrated that the G allele of 1p11-rs11249433 is a risk factor associated with increased breast cancer susceptibility, but these associations vary in different ethnic populations.
|
23977306 |
2013 |
|
Breast Carcinoma
|
|
0.770 |
GeneticVariation
|
BEFREE |
In conclusion, this meta-analysis demonstrated that the G allele of 1p11-rs11249433 is a risk factor associated with increased breast cancer susceptibility, but these associations vary in different ethnic populations.
|
23977306 |
2013 |
|
Breast Carcinoma
|
|
0.770 |
GeneticVariation
|
GWASCAT |
Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
|
23535729 |
2013 |
|
Malignant neoplasm of breast
|
|
0.770 |
GeneticVariation
|
GWASDB |
Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
|
23535729 |
2013 |
|
Breast Carcinoma
|
|
0.770 |
GeneticVariation
|
BEFREE |
Our findings demonstrated that rs11249433-G allele is a risk-conferring factor for the development of breast cancer, especially in Caucasians.
|
23977314 |
2013 |
|
Malignant neoplasm of breast
|
|
0.770 |
GeneticVariation
|
BEFREE |
Our findings demonstrated that rs11249433-G allele is a risk-conferring factor for the development of breast cancer, especially in Caucasians.
|
23977314 |
2013 |
|
Mammary Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our results in two independent data sets suggest that rs11249433, which is located between the NOTCH2 and FCGR1B genes within the 1p11.2 locus, is more strongly associated with risk of breast tumors with low or absent E-cadherin expression, and suggest that evaluation of E-cadherin tumor tissue expression may be useful in clarifying breast cancer risk factor associations.
|
24292867 |
2014 |
|
Malignant neoplasm of breast
|
|
0.770 |
GeneticVariation
|
BEFREE |
Our results in two independent data sets suggest that rs11249433, which is located between the NOTCH2 and FCGR1B genes within the 1p11.2 locus, is more strongly associated with risk of breast tumors with low or absent E-cadherin expression, and suggest that evaluation of E-cadherin tumor tissue expression may be useful in clarifying breast cancer risk factor associations.
|
24292867 |
2014 |