Ulcerative Colitis
|
|
0.050 |
GeneticVariation
|
BEFREE |
Consistently, TT genotype of C1236T and TTT haplotype were also found more frequently in UC patients.
|
29543864 |
2018 |
Ulcerative Colitis
|
|
0.050 |
GeneticVariation
|
BEFREE |
ABCB1 1236C>T polymorphism significantly affects the therapeutic efficacy of tarcolimus at 12 weeks under the tight dose-adjusting treatment for ulcerative colitis.
|
28135009 |
2017 |
Ulcerative Colitis
|
|
0.050 |
GeneticVariation
|
BEFREE |
The CC genotype and C allele of ABCB1 C1236T polymorphisms are significantly associated with UC susceptibility, so we conclude that ABCB1 C1236T polymorphisms might serve as genetic-susceptibility factors for UC.
|
25755800 |
2015 |
Ulcerative Colitis
|
|
0.050 |
GeneticVariation
|
BEFREE |
Heterozygous carriers for the variants C1236T, rs2235046 (an SNP in intron 16), and G2677T/A showed a lower risk of developing ulcerative colitis (C1236T: odds ratio [OR] = 0.63, 95% confidence interval [CI] = 0.42-0.93, P = 0.03; G2677T/A: OR = 0.59, CI = 0.39-0.89, P = 0.02; and rs2235046: OR = 0.59, 95% CI = 0.38-0.91, P = 0.009) as compared with homozygotes.
|
19685447 |
2009 |
Ulcerative Colitis
|
|
0.050 |
GeneticVariation
|
BEFREE |
SNP C1236T was significantly (P=0.05) overrepresented in the U</span>C patients.
|
19005421 |
2009 |
Infantile nystagmus syndrome
|
|
0.040 |
GeneticVariation
|
BEFREE |
C1236T polymorphism was associated with steroid resistance in INS children (odds ratio: 2.27, 95 % confidence interval: 1.2-4.4; P = 0.012).
|
27719329 |
2017 |
Infantile nystagmus syndrome
|
|
0.040 |
GeneticVariation
|
BEFREE |
MDR1 rs1128503, rs1045642, and rs2032582 polymorphisms are not associated with INS susceptibility; however, there is evidence of an association between rs1128503 and increased risk of steroid resistance in children with INS, which indicates MDR1 may play a role in steroid resistance found in children with INS.
|
28614261 |
2017 |
Breast Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
Genetic polymorphisms of MDR1 C3435T and G2677A/T, but not C1236T, are associated with increased risk of breast cancer.
|
26838221 |
2016 |
Breast Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
In this study, we examined the association between polymorphisms 3435 C/T and 1236 C/T in the ABCB1 gene and breast cancer development in Mexican women according to their menopausal status and molecular classification.
|
25730063 |
2015 |
Infantile nystagmus syndrome
|
|
0.040 |
GeneticVariation
|
BEFREE |
The purpose of the study was to investigate the distribution of insertion/deletion (I/D) polymorphisms of the angiotensin-converting enzyme (ACE) gene and three exonic polymorphisms of the multidrug resistance 1 (MDR1) gene (C3435T, C1236T, and G2677T) in children diagnosed with idiopathic nephrotic syndrome (INS).
|
26154535 |
2015 |
Colorectal Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
Therefore, we aimed to investigate the relationship between colorectal cancer and the functional common variants of ABCB1 (1236C > T; 2677G > T/A; 3435C > T).
|
23193993 |
2013 |
Infantile nystagmus syndrome
|
|
0.040 |
GeneticVariation
|
BEFREE |
Our results indicate that among our pediatric patients with INS the C1236T polymorphism in the ABCB1 gene was associated with steroid resistance, while the A6986G polymorphism in the CYP3A5 gene showed a trend of association, but did not reach statistical significance, requiring further analysis.
|
22610055 |
2012 |
Breast Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
However, we did not find statistically significant association between C1236T genotypes and the risk or prognosis of breast carcinoma.
|
22526155 |
2012 |
Breast Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
Whether ABCB1 polymorphisms including T-129C, A61G, C1236T, G2677T/A and C3435T polymorphisms could account for variations in the disposition of docetaxel and whether menopausal status at the time of diagnosis might interact with this effect were analysed in women receiving neoadjuvant chemotherapy for breast cancer (n=86).
|
20628376 |
2010 |
Colorectal Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
To analyse the single-nucleotide polymorphisms (SNPs): ABCB1(1236C>T), ABCB1(2677G>T/A), ABCB1(3435C>T) and haplotypes in the ABCB1/MDR1 gene, which could contribute to genetic risk of colorectal cancer (CRC).
|
20533057 |
2010 |
Colorectal Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
Differences in ABCB1 (1236C>T) and ABCB1 (2677G>T/A) genotypes and T(1236) allele distribution between investigated populations indicate significant impact of these SNPs on risk of development of colorectal cancer.
|
19415305 |
2009 |
Colorectal Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
In particular, carriers of the T/T genotype in exon 12 (1236 C-->T) SNP and the T/T genotype in exon 21 (2677G-->T) SNP were most significantly associated with a higher risk for developing MSI-H CRC compared to controls (P=0.01, OR=3.182 and P=0.005, OR=3.594, respectively).
|
18474294 |
2008 |
Idiopathic Nephrotic Syndrome
|
|
0.030 |
GeneticVariation
|
BEFREE |
Studies have investigated rs1128503, rs1045642, and rs2032582 in multidrug resistance protein 1 (MDR1) for association with susceptibility to idiopathic nephrotic syndrome (INS) and steroid resistance.
|
28614261 |
2017 |
Nephrotic Syndrome, Minimal Change
|
|
0.030 |
GeneticVariation
|
BEFREE |
Studies have investigated rs1128503, rs1045642, and rs2032582 in multidrug resistance protein 1 (MDR1) for association with susceptibility to idiopathic nephrotic syndrome (INS) and steroid resistance.
|
28614261 |
2017 |
Childhood Acute Lymphoblastic Leukemia
|
|
0.030 |
GeneticVariation
|
BEFREE |
The present meta-analysis found no evidence for ABCB1 C3435T and C1236T polymorphisms as risk factors for pediatric ALL.
|
28845766 |
2017 |
Parkinson Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
The NOS1 exon18 and ABCB1 1236C/T variants might play a role in the risk of Parkinson's disease, whereas NOS1 exon29 and ABCB1 3435C/T polymorphisms might not contribute to PD susceptibility.
|
27749554 |
2016 |
Parkinson Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
Overall, the analysis suggested that MDR1 C123</span>6T polymorphism substantially contribute to Parkinson's disease in the recessive genetic model.
|
27538645 |
2016 |
Malignant neoplasm of breast
|
|
0.030 |
GeneticVariation
|
BEFREE |
Genetic polymorphisms of MDR1 C3435T and G2677A/T, but not C1236T, are associated with increased risk of breast cancer.
|
26838221 |
2016 |
Crohn Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
Our data suggest that the C1236T and G2677A/T SNPs in the MDR1 gene are associated with CD and the C1236T risk allele with a more severe course of disease in Algerian pediatric patients.
|
27603561 |
2016 |
Alzheimer's Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
Here, we performed a meta-analysis to assess whether ABCB1 polymorphisms 3435C > T (rs1045642), 2677G > T/A (rs2032582), 1236C > T (rs1128503) and haplotypes were associated with AD risk.
|
27600024 |
2016 |