rs1136410, PARP1

N. diseases: 70
Disease: Primary malignant neoplasm ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Primary malignant neoplasm
CUI: C1306459
Disease: Primary malignant neoplasm
0.060 GeneticVariation BEFREE Poly(ADP-ribose) polymerase activity can be higher in cancer than in adjacent normal tissue, but cancer predisposition is reported to be greater in individuals with a single-nucleotide polymorphism (SNP) V762A (T2444C) in the catalytic domain that reduces PARP-1 activity. 19568233 2009
Primary malignant neoplasm
CUI: C1306459
Disease: Primary malignant neoplasm
0.060 GeneticVariation BEFREE Overall, no significant association was found between the PARP-1 V762A polymorphism and cancer</span> risk. 22127734 2012
Primary malignant neoplasm
CUI: C1306459
Disease: Primary malignant neoplasm
0.060 GeneticVariation BEFREE Despite some limitations, this meta-analysis found evidence for an association between the PAPR1 Val762Ala and cancer susceptibility within gastric cancer, brain tumor and Asian subgroups. 24489833 2014
Primary malignant neoplasm
CUI: C1306459
Disease: Primary malignant neoplasm
0.060 GeneticVariation BEFREE Our racial and tissue-specific summary estimates imply consideration of the Val762Ala polymorphism as candidate gene marker for screening cancer patients' best suited for PARP inhibitor therapy. 23073772 2012
Primary malignant neoplasm
CUI: C1306459
Disease: Primary malignant neoplasm
0.060 GeneticVariation BEFREE Few studies have reported an association between PARP1 Val762Ala polymorphism (rs1136410) and cancer therapy response. 27323894 2017
Primary malignant neoplasm
CUI: C1306459
Disease: Primary malignant neoplasm
0.060 GeneticVariation BEFREE The present meta-analysis provides evidence that the PARP-1 Val762Ala may be involved in cancer development at least in some ethnic groups (Asian) or some specific cancer types (gastric, cervical, and lung cancers, and glioma). 24853559 2014