|
Glioma
|
|
0.080 |
GeneticVariation
|
BEFREE |
In addition, PARP1 rs1136410 variant genotype could be beneficial for the overall survival of patients with glioma.
|
31489712 |
2019 |
|
Glioma
|
|
0.080 |
GeneticVariation
|
BEFREE |
This meta-analysis suggests that glioma susceptibility is associated with rs1799782 and rs25487 of X-ray repair complementing defective repair in Chinese hamster cells 1 (XRCC1), rs1805377 of XRCC4, rs1800067 of excision repair cross-complementing rodent repair deficiency complementation group 4 (ERCC4) and rs3212986 of ERCC1 in Asian population, and rs12917 of O-6-methylguanine-DNA methyltransferase (MGMT) and rs1136410 of poly(ADP-ribose) polymerase 1 (PARP1) in Caucasian population.
|
27055523 |
2017 |
|
Glioma
|
|
0.080 |
GeneticVariation
|
BEFREE |
This meta-analysis suggests that PARP1 rs1136410 T>C may play a significant role in the protection against the development of brain tumors and glioma.
|
25911198 |
2016 |
|
Glioma
|
|
0.080 |
GeneticVariation
|
BEFREE |
We found that SNPs rs3212986 (odds ratio [OR] = 1.35 (1.08-1.68), P = .008), rs13181 (OR = 1.18 (1.06-1.31), P = .002), and rs25487 (OR = 1.12 (1.03-1.22), P = .007) in DNA repair genes ERCC1, ERCC2 (XPD), and XRCC1 may increase the risk of glioma, while polymorphisms rs1136410 (OR = 0.78 (0.68-0.89), P = .0004) and rs12917 (OR = 0.84 (0.73-0.96), P = .01) in PARP1(ADPRT) and MGMT are associated with decreased susceptibility to glioma.
|
24500421 |
2014 |
|
Glioma
|
|
0.080 |
GeneticVariation
|
BEFREE |
The present meta-analysis provides evidence that the PARP-1 Val762Ala may be involved in cancer development at least in some ethnic groups (Asian) or some specific cancer types (gastric, cervical, and lung cancers, and glioma).
|
24853559 |
2014 |
|
Glioma
|
|
0.080 |
GeneticVariation
|
BEFREE |
In the stratified analyses, however, it was found that the variant A allele of the PARP-1 V762A polymorphism was associated with an increased risk of cancer among Asian populations (VA + AA vs. VV: OR = 1.11, 95% CI: 1.01-1.23; P(heterogeneity) = 0.210), but a decreased risk of cancer (VA + AA vs. VV: OR = 0.89, 95% CI: 0.80-1.00; P(heterogeneity) = 0.004) among Caucasian populations, especially for glioma risk (OR = 0.79, 95% CI: 0.69-0.90; P(heterogeneity) = 0.800).
|
22127734 |
2012 |
|
Glioma
|
|
0.080 |
GeneticVariation
|
BEFREE |
In this study, we aimed to investigate the associations between glioma risk and XRCC1 Arg399Gln and PARP1 Val762Ala polymorphisms per se and in combination.
|
20868244 |
2010 |
|
Glioma
|
|
0.080 |
GeneticVariation
|
BEFREE |
Furthermore, the multifactor dimensionality reduction and classification and regression tree analyses identified MGMT F84L as the predominant risk factor for glioma</span> and revealed strong interactions among ionizing radiation exposure, PARP1 A762V, MGMT F84L, and APEX1 E148D.
|
19124499 |
2009 |
|
Malignant neoplasm of breast
|
|
0.060 |
GeneticVariation
|
BEFREE |
No association was detected between rs1136410 and susceptibility to BC among studied groups.
|
31288058 |
2019 |
|
Breast Carcinoma
|
|
0.060 |
GeneticVariation
|
BEFREE |
No association was detected between rs1136410 and susceptibility to BC among studied groups.
|
31288058 |
2019 |
|
Malignant neoplasm of breast
|
|
0.060 |
GeneticVariation
|
BEFREE |
There was no evidence to suggest that rs25489, rs1799782, rs1130409, rs1805414 and rs1136410 were associated with breast cancer risk.
|
29662639 |
2018 |
|
Breast Carcinoma
|
|
0.060 |
GeneticVariation
|
BEFREE |
There was no evidence to suggest that rs25489, rs1799782, rs1130409, rs1805414 and rs1136410 were associated with breast cancer risk.
|
29662639 |
2018 |
|
Primary malignant neoplasm
|
|
0.060 |
GeneticVariation
|
BEFREE |
Few studies have reported an association between PARP1 Val762Ala polymorphism (rs1136410) and cancer therapy response.
|
27323894 |
2017 |
|
Malignant Neoplasms
|
|
0.060 |
GeneticVariation
|
BEFREE |
Few studies have reported an association between PARP1 Val762Ala polymorphism (rs1136410) and cancer therapy response.
|
27323894 |
2017 |
|
Malignant Neoplasms
|
|
0.060 |
GeneticVariation
|
BEFREE |
Despite some limitations, this meta-analysis found evidence for an association between the PAPR1 Val762Ala and cancer susceptibility within gastric cancer, brain tumor and Asian subgroups.
|
24489833 |
2014 |
|
Primary malignant neoplasm
|
|
0.060 |
GeneticVariation
|
BEFREE |
Despite some limitations, this meta-analysis found evidence for an association between the PAPR1 Val762Ala and cancer susceptibility within gastric cancer, brain tumor and Asian subgroups.
|
24489833 |
2014 |
|
Primary malignant neoplasm
|
|
0.060 |
GeneticVariation
|
BEFREE |
The present meta-analysis provides evidence that the PARP-1 Val762Ala may be involved in cancer development at least in some ethnic groups (Asian) or some specific cancer types (gastric, cervical, and lung cancers, and glioma).
|
24853559 |
2014 |
|
Malignant Neoplasms
|
|
0.060 |
GeneticVariation
|
BEFREE |
The present meta-analysis provides evidence that the PARP-1 Val762Ala may be involved in cancer development at least in some ethnic groups (Asian) or some specific cancer types (gastric, cervical, and lung cancers, and glioma).
|
24853559 |
2014 |
|
Breast Carcinoma
|
|
0.060 |
GeneticVariation
|
BEFREE |
We aimed to explore the modification effects of PARP1 rs1136410 and ESR1 rs2234693 on the association between passive smoking and breast cancer risk among pre- and post-menopausal women.
|
23644255 |
2013 |
|
Breast Carcinoma
|
|
0.060 |
GeneticVariation
|
BEFREE |
Taken together, this the first study that confirmed Val762Ala variant has functional effect and structural impact on the PARP1 and may play an important role in breast cancer progression in Saudi population.
|
24392019 |
2013 |
|
Malignant neoplasm of breast
|
|
0.060 |
GeneticVariation
|
BEFREE |
We aimed to explore the modification effects of PARP1 rs1136410 and ESR1 rs2234693 on the association between passive smoking and breast cancer risk among pre- and post-menopausal women.
|
23644255 |
2013 |
|
Malignant neoplasm of breast
|
|
0.060 |
GeneticVariation
|
BEFREE |
Taken together, this the first study that confirmed Val762Ala variant has functional effect and structural impact on the PARP1 and may play an important role in breast cancer progression in Saudi population.
|
24392019 |
2013 |
|
Primary malignant neoplasm
|
|
0.060 |
GeneticVariation
|
BEFREE |
Overall, no significant association was found between the PARP-1 V762A polymorphism and cancer</span> risk.
|
22127734 |
2012 |
|
Malignant neoplasm of breast
|
|
0.060 |
GeneticVariation
|
BEFREE |
This meta-analysis indicates that ADPRT Val762Ala and APE1 Asp148Glu polymorphisms are not associated with increased breast cancer risk.
|
23272074 |
2012 |
|
Breast Carcinoma
|
|
0.060 |
GeneticVariation
|
BEFREE |
This meta-analysis indicates that ADPRT Val762Ala and APE1 Asp148Glu polymorphisms are not associated with increased breast cancer risk.
|
23272074 |
2012 |