|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The K109R polymorphism was associated with obesity (P = .025) and seems to significantly decrease the LEP levels (P < .001).
|
29893028 |
2018 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study was to investigate the prevalence of single nucleotide polymorphisms (SNPs) in leptin gene LEP (A19G and G2548A) and leptin receptor gene LEPR (K109R and Q223R) and their association with fasting plasma leptin level (PLL) and obesity in a Malaysian suburban population in Kampar, Perak.
|
24947733 |
2014 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Taken together, our data suggest that a combination of polymorphism in the LEP gene 3' flanking region, and Lys109Arg, Lys656Asn variants in LEPR gene is associated with obesity in Chinese Han population.
|
24308887 |
2013 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Allele dosage analysis of rs2069845, rs1137100, and rs3801266 revealed that children with five to six risk alleles had an approximately four times increased risk of obesity than children with less than two risk alleles (P = 1.2 × 10(-7)).
|
22228719 |
2012 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study evaluated the association between obesity and the K109R, Q223R, and K656N polymorphisms of the leptin receptor (LEPR) locus.
|
22746211 |
2012 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
We searched electronic databases, including population-based studies that investigated the association between LEPR variants Q223R, K109R and K656N and obesity- related phenotypes in healthy, unrelated subjects.
|
22028824 |
2011 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our findings suggest that c.517A→G and Lys(109)Arg contribute to the variation in anthropometric obesity phenotype indicators observed among Black African and mixed-ancestry South African learners.
|
21921635 |
2011 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The other two polymorphisms, G-2548A and K109R, were associated with neither body weight, BMI, nor obesity.
|
20183928 |
2010 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Some polymorphic genes involved in the regulation of leptin-the leptin gene (LEP A19G), the leptin receptor gene (LEPR Q223R, K109R, and K656N), and the peroxisome proliferator-activated receptor-gamma gene (PPARG P12A and C161T)--have been investigated as possible factors associated with obesity.
|
15972940 |
2005 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
These findings support the hypothesis that the Q223R polymorphism (but not the K109R or K656N polymorphism) of the leptin receptor gene is associated with obesity and predicts a small percentage of body weight and body composition variability in a genetically homogeneous population.
|
11549688 |
2001 |