rs114580964, PRRC2A

N. diseases: 1
Disease: Lupus Nephritis ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Lupus Nephritis
CUI: C0024143
Disease: Lupus Nephritis
0.010 GeneticVariation BEFREE We discovered five independent risk variants for LN within the MHC region, including <i>HLA-DRβ1</i> amino acid 11 (<i>P</i><sub>omnibus</sub><0.001), <i>HLA-DQβ1</i> amino acid 45 (<i>P</i><0.001; odds ratio, 0.58; 95% confidence interval, 0.52 to 0.65), <i>HLA-A</i> amino acid 156 (<i>P</i><sub>omnibus</sub><0.001), <i>HLA-DPβ1</i> amino acid 76 (<i>P</i><sub>omnibus</sub><0.001), and a missense variant in <i>PRRC2A</i> (rs114580964; <i>P</i><0.001; odds ratio, 0.38; 95% confidence interval, 0.30 to 0.49) at genome-wide significance. 28754791 2017