rs11591147, PCSK9

N. diseases: 28
Disease: Vascular Diseases ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Vascular Diseases
CUI: C0042373
Disease: Vascular Diseases
0.020 GeneticVariation BEFREE R46L polymorphism in the PCSK9 gene: Relationship to lipid levels, subclinical vascular disease, and erectile dysfunction. 29773421 2019
Vascular Diseases
CUI: C0042373
Disease: Vascular Diseases
0.020 GeneticVariation BEFREE In this population 3.5% were carriers of the T allele at R46L, and these subjects had significantly (p<0.001) lower levels of LDL C (mean, -10%), no difference in LDL C lowering response to pravastatin, and a non-significant 19% unadjusted and 9% adjusted decreased risk of vascular disease at baseline, with no on trial effect. 18262190 2008