|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We evaluated the associations of <i>miR-499A</i>>G (rs3746444), <i>miR-149C</i>>T (rs2292832), <i>miR-196a2T</i>>C (rs11614913), and <i>miR-146aG</i>>C (rs2910164) with HCC susceptibility in 100 HCC patients (70 males and 30 females) and 120 healthy controls (70 males and 50 females), using the PCR-restriction fragment length polymorphism method.
|
30215231 |
2019 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
For miR-196a2 (rs11614913) C>T polymorphisms, no significant association was found with HCC risk.
|
31759375 |
2019 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The results showed that miR-196a2 rs11614913 polymorphism is associated with cancer susceptibility, especially in lung cancer (homozygote comparison, OR =0.840, 95% CI =0.734-0.961; recessive model, OR =0.858, 95% CI =0.771-0.955), hepatocellular carcinoma (allelic contrast, OR =0.894, 95% CI =0.800-0.998; homozygote comparison, OR =0.900, 95% CI =0.813-0.997; recessive model, OR =0.800, 95% CI =0.678-0.944), and head and neck cancer (allelic contrast, OR =1.076, 95% CI =1.006-1.152; homozygote comparison, OR =1.214, 95% CI =1.043-1.413).
|
29535537 |
2018 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, hsa-<i>mir-146a</i> rs2910164 and hsa-<i>mir-34b/c</i> rs4938723 could be biomarkers for the HCC risk while hsa-<i>mir-196a-2</i> rs11614913 and hsa-<i>mir-149</i> rs2292832 had potential to be biomarkers for HBV-related HCC risk.
|
29976775 |
2018 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In addition, we found that rs2292832 and rs11614913 were associated with risk of HBV infection, viral clearance and cirrhosis+HCC, whereas rs2910164 was associated with proneness to HBV infection, and ability to clear the virus.
|
28685993 |
2017 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
To evaluate the association between four common miRNAs (miR-146a rs2910164; miR-149 rs2292832; miR-196a2 rs11614913 and miR-499 rs3746444) and HCC risk, an updated meta-analysis was performed.
|
28499985 |
2017 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, miR-146a C>G (rs2910164) can increase HBV-related HCC risk while miR-196a-2 C>T (rs11614913) may decrease the risk of HBV- and HCV-related HCC, especially in the Chinese population.
|
28148887 |
2017 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our findings supported the proposition that the polymorphisms of miR-146a rs2910164, miR-196a2 rs11614913, and miR-196a2 rs11614913 may contribute to the susceptibility of HCC.
|
28188097 |
2017 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, the donor miR-196a-2 rs11614913 polymorphism is associated with HCC recurrence after LT and improves the predictive value of clinical models.
|
26365437 |
2016 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In this study, we found that the CT+CC genotypes of rs11614913 were significantly associated with an increased risk and poor prognosis for HCC in the Chinese population.
|
26866381 |
2016 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
MiR-196a2 rs11614913 and miR-499a rs3746444 were significantly associated with a curative effect and a positive prognosis of TACE for primary HCC.
|
27525669 |
2016 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Predictive role of miR-146a rs2910164 (C>G), miR-149 rs2292832 (T>C), miR-196a2 rs11614913 (T>C) and miR-499 rs3746444 (T>C) in the development of hepatocellular carcinoma.
|
26823863 |
2015 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
With respect to miR-196a2 rs11614913 polymorphism, no significant association with HCC risk was found in the overall and subgroup analyses.
|
25546664 |
2014 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
rs4938723 might be a genetic risk factor of HCC but its effect on HCC is significantly affected by the HBV mutations. rs11614913 might not be a HCC susceptible factor but it might affect the effects of the HBV mutations or rs4938723 on HCC risk.
|
23516510 |
2013 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study demonstrated a role of rs11614913 in the etiology of HCC.
|
24377545 |
2013 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We did not find a significant association between miR-196a2 rs11614913 polymorphism and hepatocellular carcinoma risk.
|
23160898 |
2013 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
This meta-analysis suggests that two common SNPs rs2910164 and rs11614913 are not associated with the risk of HCC.
|
22768213 |
2012 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our data shows that the CC genotype of the miR-196a-2 rs11614913 polymorphism is associated with increased risk of HCC development in this Turkish population (OR = 2.41, 95% CI: 1.30-4.50, P = 0.005).
|
21692953 |
2011 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In our study group, there was no significant association between MIR196A2 polymorphism and the risk of HBV-related HCC in all subjects, however, the risk of HCC was significantly higher with MIR196A2 rs11614913 CC genotype or C allele compared with those with the TT genotype or T allele in male patients.
|
20188135 |
2010 |