Alcohol consumption
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions.
|
30698716 |
2019 |
Arteriosclerosis
|
|
0.030 |
GeneticVariation
|
BEFREE |
We examined whether dietary macronutrient intake modified associations between ANGPTL4[E40K] variation and TG and HDL-C in White men and women from the Atherosclerosis Risk in Communities study.
|
18599063 |
2009 |
Arteriosclerosis
|
|
0.030 |
GeneticVariation
|
BEFREE |
The prospective, population-based Atherosclerosis Risk in Communities Study measured the E40K ANGPTL4 variant in approximately 10000 white participants and determined its association with coronary heart disease (CHD) incidence (n = 1318 events) between 1987-1989 and 2004.
|
18940399 |
2008 |
Arteriosclerosis
|
|
0.030 |
GeneticVariation
|
BEFREE |
Longitudinal changes in triglycerides according to ANGPTL4[E40K] genotype and longitudinal body weight change in the atherosclerosis risk in communities study.
|
18809343 |
2008 |
Atherosclerosis
|
|
0.030 |
GeneticVariation
|
BEFREE |
The prospective, population-based Atherosclerosis Risk in Communities Study measured the E40K ANGPTL4 variant in approximately 10000 white participants and determined its association with coronary heart disease (CHD) incidence (n = 1318 events) between 1987-1989 and 2004.
|
18940399 |
2008 |
Atherosclerosis
|
|
0.030 |
GeneticVariation
|
BEFREE |
We examined whether dietary macronutrient intake modified associations between ANGPTL4[E40K] variation and TG and HDL-C in White men and women from the Atherosclerosis Risk in Communities study.
|
18599063 |
2009 |
Atherosclerosis
|
|
0.030 |
GeneticVariation
|
BEFREE |
Longitudinal changes in triglycerides according to ANGPTL4[E40K] genotype and longitudinal body weight change in the atherosclerosis risk in communities study.
|
18809343 |
2008 |
Cardiovascular Diseases
|
|
0.030 |
GeneticVariation
|
BEFREE |
So, T266M and E40K polymorphism predicts cardiovascular disease risk in Type 2 diabetic Tunisian population.
|
27004807 |
2016 |
Cardiovascular Diseases
|
|
0.030 |
GeneticVariation
|
BEFREE |
Conflicting results have been obtained regarding whether the E40K variant (a loss-of-function mutation of Angptl4) is associated with an increased risk for cardiovascular disease, which may occur due to the lipid-independent actions of Angptl4.
|
19851103 |
2010 |
Cardiovascular Diseases
|
|
0.030 |
GeneticVariation
|
BEFREE |
An E40K loss-of-function variant in the ANGPTL4 gene is associated with substantially reduced plasma triglyceride levels in white persons, but its association with cardiovascular disease occurrence has not been reported.
|
18940399 |
2008 |
Coronary Arteriosclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Carriers of E40K and other inactivating mutations in ANGPTL4 had lower levels of triglycerides and a lower risk of coronary artery disease than did noncarriers.
|
26933753 |
2016 |
Coronary Artery Disease
|
|
0.710 |
GeneticVariation
|
GWASCAT |
Association analyses based on false discovery rate implicate new loci for coronary artery disease.
|
28714975 |
2017 |
Coronary Artery Disease
|
|
0.710 |
GeneticVariation
|
BEFREE |
Carriers of E40K and other inactivating mutations in ANGPTL4 had lower levels of triglycerides and a lower risk of coronary artery disease than did noncarriers.
|
26933753 |
2016 |
Coronary Artery Disease
|
|
0.710 |
GeneticVariation
|
GWASCAT |
Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease.
|
29212778 |
2018 |
Coronary heart disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
The prospective, population-based Atherosclerosis Risk in Communities Study measured the E40K ANGPTL4 variant in approximately 10000 white participants and determined its association with coronary heart disease (CHD) incidence (n = 1318 events) between 1987-1989 and 2004.
|
18940399 |
2008 |
Coronary heart disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
Carriers of E40K and other inactivating mutations in ANGPTL4 had lower levels of triglycerides and a lower risk of coronary artery disease than did noncarriers.
|
26933753 |
2016 |
Coronary heart disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
Circulating Angptl4 levels may not influence TG levels or CHD risk for the following reasons: (1) Angptl4 levels were not correlated with TGs; (2) T266M, although associated with Angptl4 levels, showed no association with plasma TGs; and (3) TG-lowering E40K did not influence Angptl4 levels.
|
20829508 |
2010 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.020 |
GeneticVariation
|
BEFREE |
Carriers of p.E40K, a variant that abolishes ANGPTL4 ability to inhibit lipoprotein lipase, have lower odds of T2D (odds ratio 0.89, 95% confidence interval 0.85-0.92, p = 6.3 × 10<sup>-10</sup>), lower fasting glucose, and greater insulin sensitivity.
|
29899519 |
2018 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.020 |
GeneticVariation
|
BEFREE |
We investigated the effect of the tagging single nucleotide polymorphisms (SNPs) rs1044250 (T266M) and rs116843064 (E40K) with triglyceride (TG) levels and CAD risk factors in a cohort of 220 patients undergoing coronary angiography for the evaluation of stable CAD, all of whom had (type 2 diabetes) T2D and were at least overweight.
|
27004807 |
2016 |
High density lipoprotein measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Common, low-frequency, and rare genetic variants associated with lipoprotein subclasses and triglyceride measures in Finnish men from the METSIM study.
|
29084231 |
2017 |
High density lipoprotein measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
The impact of low-frequency and rare variants on lipid levels.
|
25961943 |
2015 |
High density lipoprotein measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks.
|
24507774 |
2014 |
High density lipoprotein measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions.
|
30698716 |
2019 |
High density lipoprotein measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
A large electronic-health-record-based genome-wide study of serum lipids.
|
29507422 |
2018 |
High density lipoprotein measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Exploration of haplotype research consortium imputation for genome-wide association studies in 20,032 Generation Scotland participants.
|
28270201 |
2017 |