Coronary Artery Disease
|
|
0.710 |
GeneticVariation
|
BEFREE |
Carriers of E40K and other inactivating mutations in ANGPTL4 had lower levels of triglycerides and a lower risk of coronary artery disease than did noncarriers.
|
26933753 |
2016 |
Arteriosclerosis
|
|
0.030 |
GeneticVariation
|
BEFREE |
We examined whether dietary macronutrient intake modified associations between ANGPTL4[E40K] variation and TG and HDL-C in White men and women from the Atherosclerosis Risk in Communities study.
|
18599063 |
2009 |
Cardiovascular Diseases
|
|
0.030 |
GeneticVariation
|
BEFREE |
So, T266M and E40K polymorphism predicts cardiovascular disease risk in Type 2 diabetic Tunisian population.
|
27004807 |
2016 |
Atherosclerosis
|
|
0.030 |
GeneticVariation
|
BEFREE |
The prospective, population-based Atherosclerosis Risk in Communities Study measured the E40K ANGPTL4 variant in approximately 10000 white participants and determined its association with coronary heart disease (CHD) incidence (n = 1318 events) between 1987-1989 and 2004.
|
18940399 |
2008 |
Coronary heart disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
The prospective, population-based Atherosclerosis Risk in Communities Study measured the E40K ANGPTL4 variant in approximately 10000 white participants and determined its association with coronary heart disease (CHD) incidence (n = 1318 events) between 1987-1989 and 2004.
|
18940399 |
2008 |
Atherosclerosis
|
|
0.030 |
GeneticVariation
|
BEFREE |
We examined whether dietary macronutrient intake modified associations between ANGPTL4[E40K] variation and TG and HDL-C in White men and women from the Atherosclerosis Risk in Communities study.
|
18599063 |
2009 |
Cardiovascular Diseases
|
|
0.030 |
GeneticVariation
|
BEFREE |
Conflicting results have been obtained regarding whether the E40K variant (a loss-of-function mutation of Angptl4) is associated with an increased risk for cardiovascular disease, which may occur due to the lipid-independent actions of Angptl4.
|
19851103 |
2010 |
Coronary heart disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
Carriers of E40K and other inactivating mutations in ANGPTL4 had lower levels of triglycerides and a lower risk of coronary artery disease than did noncarriers.
|
26933753 |
2016 |
Arteriosclerosis
|
|
0.030 |
GeneticVariation
|
BEFREE |
The prospective, population-based Atherosclerosis Risk in Communities Study measured the E40K ANGPTL4 variant in approximately 10000 white participants and determined its association with coronary heart disease (CHD) incidence (n = 1318 events) between 1987-1989 and 2004.
|
18940399 |
2008 |
Cardiovascular Diseases
|
|
0.030 |
GeneticVariation
|
BEFREE |
An E40K loss-of-function variant in the ANGPTL4 gene is associated with substantially reduced plasma triglyceride levels in white persons, but its association with cardiovascular disease occurrence has not been reported.
|
18940399 |
2008 |
Arteriosclerosis
|
|
0.030 |
GeneticVariation
|
BEFREE |
Longitudinal changes in triglycerides according to ANGPTL4[E40K] genotype and longitudinal body weight change in the atherosclerosis risk in communities study.
|
18809343 |
2008 |
Coronary heart disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
Circulating Angptl4 levels may not influence TG levels or CHD risk for the following reasons: (1) Angptl4 levels were not correlated with TGs; (2) T266M, although associated with Angptl4 levels, showed no association with plasma TGs; and (3) TG-lowering E40K did not influence Angptl4 levels.
|
20829508 |
2010 |
Atherosclerosis
|
|
0.030 |
GeneticVariation
|
BEFREE |
Longitudinal changes in triglycerides according to ANGPTL4[E40K] genotype and longitudinal body weight change in the atherosclerosis risk in communities study.
|
18809343 |
2008 |
Metabolic Syndrome X
|
|
0.020 |
GeneticVariation
|
BEFREE |
The G allele at the rs116843064 polymorphic locus of the ANGPTL4 gene was associated with a lower prevalence of MetS.
|
31164103 |
2019 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.020 |
GeneticVariation
|
BEFREE |
Carriers of p.E40K, a variant that abolishes ANGPTL4 ability to inhibit lipoprotein lipase, have lower odds of T2D (odds ratio 0.89, 95% confidence interval 0.85-0.92, p = 6.3 × 10<sup>-10</sup>), lower fasting glucose, and greater insulin sensitivity.
|
29899519 |
2018 |
Obesity
|
|
0.020 |
GeneticVariation
|
BEFREE |
The objective of this study was to determine whether ANGPTL4 E40K and T266M are associated with triglyceride levels in the setting of obesity and T2D, and whether modification of triglyceride levels by these genetic variants is altered by a lifestyle intervention designed to treat T2D.
|
21714923 |
2011 |
Obesity
|
|
0.020 |
GeneticVariation
|
BEFREE |
The objective of this study was to investigate the association of ANGPTL4 variants (E40K and T266M) with triglyceride levels and with cardiovascular risk factors, such as metabolic syndrome (MetS) and obesity in type 2 diabetic Tunisian population.
|
27004807 |
2016 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.020 |
GeneticVariation
|
BEFREE |
We investigated the effect of the tagging single nucleotide polymorphisms (SNPs) rs1044250 (T266M) and rs116843064 (E40K) with triglyceride (TG) levels and CAD risk factors in a cohort of 220 patients undergoing coronary angiography for the evaluation of stable CAD, all of whom had (type 2 diabetes) T2D and were at least overweight.
|
27004807 |
2016 |
Metabolic Syndrome X
|
|
0.020 |
GeneticVariation
|
BEFREE |
The objective of this study was to investigate the association of ANGPTL4 variants (E40K and T266M) with triglyceride levels and with cardiovascular risk factors, such as metabolic syndrome (MetS) and obesity in type 2 diabetic Tunisian population.
|
27004807 |
2016 |
Coronary Arteriosclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Carriers of E40K and other inactivating mutations in ANGPTL4 had lower levels of triglycerides and a lower risk of coronary artery disease than did noncarriers.
|
26933753 |
2016 |
PLASMA TRIGLYCERIDE LEVEL QUANTITATIVE TRAIT LOCUS
|
|
0.700 |
GeneticVariation
|
CLINVAR |
|
|
|
Coronary Artery Disease
|
|
0.710 |
GeneticVariation
|
GWASCAT |
Association analyses based on false discovery rate implicate new loci for coronary artery disease.
|
28714975 |
2017 |
Coronary Artery Disease
|
|
0.710 |
GeneticVariation
|
GWASCAT |
Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease.
|
29212778 |
2018 |
High density lipoprotein measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Common, low-frequency, and rare genetic variants associated with lipoprotein subclasses and triglyceride measures in Finnish men from the METSIM study.
|
29084231 |
2017 |
High density lipoprotein measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
The impact of low-frequency and rare variants on lipid levels.
|
25961943 |
2015 |