PLASMA TRIGLYCERIDE LEVEL QUANTITATIVE TRAIT LOCUS
|
|
0.700 |
GeneticVariation
|
CLINVAR |
|
|
|
High density lipoprotein measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
A large electronic-health-record-based genome-wide study of serum lipids.
|
29507422 |
2018 |
Triglycerides measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
A large electronic-health-record-based genome-wide study of serum lipids.
|
29507422 |
2018 |
Cardiovascular Diseases
|
|
0.030 |
GeneticVariation
|
BEFREE |
An E40K loss-of-function variant in the ANGPTL4 gene is associated with substantially reduced plasma triglyceride levels in white persons, but its association with cardiovascular disease occurrence has not been reported.
|
18940399 |
2008 |
Coronary Artery Disease
|
|
0.710 |
GeneticVariation
|
GWASCAT |
Association analyses based on false discovery rate implicate new loci for coronary artery disease.
|
28714975 |
2017 |
High density lipoprotein measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks.
|
24507774 |
2014 |
Triglycerides measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks.
|
24507774 |
2014 |
Coronary Artery Disease
|
|
0.710 |
GeneticVariation
|
BEFREE |
Carriers of E40K and other inactivating mutations in ANGPTL4 had lower levels of triglycerides and a lower risk of coronary artery disease than did noncarriers.
|
26933753 |
2016 |
Coronary heart disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
Carriers of E40K and other inactivating mutations in ANGPTL4 had lower levels of triglycerides and a lower risk of coronary artery disease than did noncarriers.
|
26933753 |
2016 |
Coronary Arteriosclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Carriers of E40K and other inactivating mutations in ANGPTL4 had lower levels of triglycerides and a lower risk of coronary artery disease than did noncarriers.
|
26933753 |
2016 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.020 |
GeneticVariation
|
BEFREE |
Carriers of p.E40K, a variant that abolishes ANGPTL4 ability to inhibit lipoprotein lipase, have lower odds of T2D (odds ratio 0.89, 95% confidence interval 0.85-0.92, p = 6.3 × 10<sup>-10</sup>), lower fasting glucose, and greater insulin sensitivity.
|
29899519 |
2018 |
Coronary heart disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
Circulating Angptl4 levels may not influence TG levels or CHD risk for the following reasons: (1) Angptl4 levels were not correlated with TGs; (2) T266M, although associated with Angptl4 levels, showed no association with plasma TGs; and (3) TG-lowering E40K did not influence Angptl4 levels.
|
20829508 |
2010 |
High density lipoprotein measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Common, low-frequency, and rare genetic variants associated with lipoprotein subclasses and triglyceride measures in Finnish men from the METSIM study.
|
29084231 |
2017 |
Phospholipid measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Common, low-frequency, and rare genetic variants associated with lipoprotein subclasses and triglyceride measures in Finnish men from the METSIM study.
|
29084231 |
2017 |
Triglycerides measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Common, low-frequency, and rare genetic variants associated with lipoprotein subclasses and triglyceride measures in Finnish men from the METSIM study.
|
29084231 |
2017 |
Cardiovascular Diseases
|
|
0.030 |
GeneticVariation
|
BEFREE |
Conflicting results have been obtained regarding whether the E40K variant (a loss-of-function mutation of Angptl4) is associated with an increased risk for cardiovascular disease, which may occur due to the lipid-independent actions of Angptl4.
|
19851103 |
2010 |
High density lipoprotein measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Exploration of haplotype research consortium imputation for genome-wide association studies in 20,032 Generation Scotland participants.
|
28270201 |
2017 |
Triglycerides measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program.
|
30275531 |
2018 |
High density lipoprotein measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program.
|
30275531 |
2018 |
Coronary Artery Disease
|
|
0.710 |
GeneticVariation
|
GWASCAT |
Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease.
|
29212778 |
2018 |
RDW - Red blood cell distribution width result
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
Red cell distribution width determination
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
Arteriosclerosis
|
|
0.030 |
GeneticVariation
|
BEFREE |
Longitudinal changes in triglycerides according to ANGPTL4[E40K] genotype and longitudinal body weight change in the atherosclerosis risk in communities study.
|
18809343 |
2008 |
Atherosclerosis
|
|
0.030 |
GeneticVariation
|
BEFREE |
Longitudinal changes in triglycerides according to ANGPTL4[E40K] genotype and longitudinal body weight change in the atherosclerosis risk in communities study.
|
18809343 |
2008 |
Triglycerides measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels.
|
27036123 |
2016 |