<b>Results</b>: Three out of 10 eligible SNPs were shown to be associated with risk of ischemic stroke. rs1800947 in <i>CRP</i> gene (additive model: OR = 2.08, 95% CI: 1.00-4.23) and rs1169288 in <i>HNF1A</i> gene (additive model: OR = 1.45, 95% CI: 1.03-2.06) were associated with an increased risk of ischemic stroke. rs440446 in <i>APOE</i> gene (additive model: OR = 0.63, 95%CI: 0.44-0.88) was associated with a decreased risk of ischemic stroke.
Interactions of SNP-SNP (rs1169288-rs2464196-rs2650000) and haplotype-environment on the risk of CAD (A-C-G-A-smoking) or IS (A-C-G-A-sex and A-T-A-C-alcohol consumption) were also observed among these SNPs.