| Disease | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Malignant neoplasm of breast
|
0.700 | CausalMutation | CLINVAR | Mutations in BRCA2 and PALB2 in male breast cancer cases from the United States. | 20927582 | 2011 | |||||
Malignant neoplasm of breast
|
0.700 | CausalMutation | CLINVAR | Mutations in BRCA2 and PALB2 in male breast cancer cases from the United States. | 20927582 | 2011 | |||||
Neoplastic Syndromes, Hereditary
|
0.700 | CausalMutation | CLINVAR | PALB2 mutations in German and Russian patients with bilateral breast cancer. | 21165770 | 2011 | |||||
Malignant neoplasm of breast
|
0.700 | CausalMutation | CLINVAR | PALB2 functionally connects the breast cancer susceptibility proteins BRCA1 and BRCA2. | 19584259 | 2009 | |||||
Malignant neoplasm of breast
|
0.700 | CausalMutation | CLINVAR | Structural basis for recruitment of BRCA2 by PALB2. | 19609323 | 2009 | |||||
Hereditary Breast and Ovarian Cancer Syndrome
|
0.700 | CausalMutation | CLINVAR | Structural basis for recruitment of BRCA2 by PALB2. | 19609323 | 2009 | |||||
Malignant neoplasm of breast
|
0.700 | CausalMutation | CLINVAR | PALB2 functionally connects the breast cancer susceptibility proteins BRCA1 and BRCA2. | 19584259 | 2009 | |||||
Neoplastic Syndromes, Hereditary
|
0.700 | CausalMutation | CLINVAR | PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene. | 17200668 | 2007 | |||||
Malignant neoplasm of breast
|
0.700 | CausalMutation | CLINVAR | Biallelic mutations in PALB2 cause Fanconi anemia subtype FA-N and predispose to childhood cancer. | 17200671 | 2007 | |||||
Neoplastic Syndromes, Hereditary
|
0.700 | CausalMutation | CLINVAR | Biallelic mutations in PALB2 cause Fanconi anemia subtype FA-N and predispose to childhood cancer. | 17200671 | 2007 | |||||
Neoplastic Syndromes, Hereditary
|
0.700 | CausalMutation | CLINVAR | Biallelic mutations in PALB2 cause Fanconi anemia subtype FA-N and predispose to childhood cancer. | 17200671 | 2007 | |||||
Hereditary Breast and Ovarian Cancer Syndrome
|
0.700 | CausalMutation | CLINVAR | Biallelic mutations in PALB2 cause Fanconi anemia subtype FA-N and predispose to childhood cancer. | 17200671 | 2007 | |||||
Malignant neoplasm of breast
|
0.700 | CausalMutation | CLINVAR | PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene. | 17200668 | 2007 | |||||
PANCREATIC CANCER, SUSCEPTIBILITY TO, 3
|
0.700 | CausalMutation | CLINVAR | ||||||||
BREAST CANCER, SUSCEPTIBILITY TO
|
0.700 | SusceptibilityMutation | CLINVAR | ||||||||
Malignant neoplasm of breast
|
0.700 | GeneticVariation | CLINVAR | ||||||||
Esophageal atresia with or without tracheoesophageal fistula
|
0.700 | CausalMutation | CLINVAR | ||||||||
FANCONI ANEMIA, COMPLEMENTATION GROUP N
|
0.700 | CausalMutation | CLINVAR | ||||||||
Malignant neoplasm of ovary
|
0.700 | CausalMutation | CLINVAR | ||||||||
PANCREATIC CANCER, SUSCEPTIBILITY TO, 3
|
0.700 | CausalMutation | CLINVAR | ||||||||
FANCONI ANEMIA, COMPLEMENTATION GROUP N
|
0.700 | CausalMutation | CLINVAR | ||||||||
Malignant Neoplasms
|
0.010 | GeneticVariation | BEFREE | Here we report a rare known deleterious PALB2 mutation (rs118203998) causing a premature truncation of the protein (p.Y1183X) in an individual who had developed four different cancer types, including melanoma. | 24949998 | 2014 | |||||
Primary malignant neoplasm
|
0.010 | GeneticVariation | BEFREE | Here we report a rare known deleterious PALB2 mutation (rs118203998) causing a premature truncation of the protein (p.Y1183X) in an individual who had developed four different cancer types, including melanoma. | 24949998 | 2014 | |||||
melanoma
|
0.010 | GeneticVariation | BEFREE | Here we report a rare known deleterious PALB2 mutation (rs118203998) causing a premature truncation of the protein (p.Y1183X) in an individual who had developed four different cancer types, including melanoma. | 24949998 | 2014 |