|
Glioma
|
|
0.850 |
GeneticVariation
|
GWASCAT |
Sex-specific glioma genome-wide association study identifies new risk locus at 3p21.31 in females, and finds sex-differences in risk at 8q24.21.
|
29743610 |
2018 |
|
Glioma
|
|
0.850 |
GeneticVariation
|
BEFREE |
In addition, rs11506105 was significantly associated with an increased risk of glioma in both Asians and Caucasians, and rs11979158 decreased the risk of glioma in Caucasians.
|
29156842 |
2017 |
|
Glioma
|
|
0.850 |
GeneticVariation
|
BEFREE |
Additionally, subgroup analysis by stages of glioma found that variation of rs11979158 had stronger relationship with high-grade (OR = 1.32, 95 %CI = 1.19-1.45) than low-grade glioma (OR = 1.12, 95 % CI = 1.03-1.21).
|
26243184 |
2016 |
|
Glioma
|
|
0.850 |
GeneticVariation
|
BEFREE |
Genome-wide association studies have identified single-nucleotide polymorphisms (SNPs) at 7 loci influencing glioma risk: rs2736100 (TERT), rs11979158 and rs2252586 (EGFR), rs4295627 (CCDC26), rs4977756 (CDKN2A/CDKN2B), rs498872 (PHLDB1), and rs6010620 (RTEL1).
|
23161787 |
2013 |
|
Glioma
|
|
0.850 |
GeneticVariation
|
BEFREE |
Using these data, we demonstrate two statistically independent associations between glioma and rs11979158 and rs2252586, at 7p11.2 which encompasses the EGFR gene (population-corrected statistics, P(c) = 7.72 × 10(-8) and 2.09 × 10(-8), respectively).
|
21531791 |
2011 |
|
Glioma
|
|
0.850 |
GeneticVariation
|
GWASCAT |
Using these data, we demonstrate two statistically independent associations between glioma and rs11979158 and rs2252586, at 7p11.2 which encompasses the EGFR gene (population-corrected statistics, P(c) = 7.72 × 10(-8) and 2.09 × 10(-8), respectively).
|
21531791 |
2011 |
|
Glioma
|
|
0.850 |
GeneticVariation
|
GWASDB |
Using these data, we demonstrate two statistically independent associations between glioma and rs11979158 and rs2252586, at 7p11.2 which encompasses the EGFR gene (population-corrected statistics, P(c) = 7.72 × 10(-8) and 2.09 × 10(-8), respectively).
|
21531791 |
2011 |
|
Glioma
|
|
0.850 |
GeneticVariation
|
BEFREE |
Seven independent chromosomal loci have robustly been associated with glioma risk: 5p15.33 (rs2736100, TERT), 8q24.21 (rs4295627, CCDC26), 9p21.3 (rs4977756, CDKN2A-CDKN2B), 20q13.33 (rs6010620, RTEL1), and 11q23.3 (rs498872, PHLDB1), and two loci at 7p11.2 (rs11979158 and rs2252586, EGFR).
|
21825990 |
2011 |
|
Glioblastoma Multiforme
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Age-specific genome-wide association study in glioblastoma identifies increased proportion of 'lower grade glioma'-like features associated with younger age.
|
30152087 |
2018 |
|
Glioblastoma
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Age-specific genome-wide association study in glioblastoma identifies increased proportion of 'lower grade glioma'-like features associated with younger age.
|
30152087 |
2018 |
|
Central Nervous System Neoplasms
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Chromosome 7p11.2 (EGFR) variation influences glioma risk.
|
21531791 |
2011 |
|
Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
In contrast, rs4977756 (CDKN2A/B), rs11979158 (EGFR), and to a lesser extent, rs2252586 (EGFR) risk alleles were independent of tumor grade and genetic profile.
|
23161787 |
2013 |