rs120074175, TPH2

N. diseases: 7
Disease: Major Depressive Disorder ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Major Depressive Disorder
CUI: C1269683
Disease: Major Depressive Disorder
0.030 GeneticVariation BEFREE Chinese Han individuals with at least one rs11178997 T allele or rs120074175 A allele are susceptible to MD even in the relative absence of high-negative life events. 26386440 2015
Major Depressive Disorder
CUI: C1269683
Disease: Major Depressive Disorder
0.030 GeneticVariation BEFREE This mutant is equivalent to a rare human variant (R441H) identified in few individuals with unipolar major depression. 18212115 2008
Major Depressive Disorder
CUI: C1269683
Disease: Major Depressive Disorder
0.030 GeneticVariation BEFREE It was recently reported that a rare functional variant, R441H, in the human tryptophan hydroxylase-2 gene (hTPH2) could represent an important risk factor for unipolar major depression (UP) since it was originally found in 10% of UP patients (vs. 1.4% in control subjects). 16581035 2006